The average bus between Manchester and Southwark takes 5h 41m and the fastest bus takes 4h 33m. There is a bus service every few hours from Manchester to Southwark. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Manchester and Southwark. The earliest departure is at 2:45 AM at night, and the last departure from Manchester is at 7:30 PM which arrives into Southwark at 12:03 AM. All services require a transfer at Marble Arch and take an average of 5h 41m. The schedules shown below are for the next available departures.

6h 23m • 1 change

5h 29m • 1 change

6h 23m • 1 change

5h 31m • 1 change

6h 23m • 1 change

5h 28m • 1 change

5h 23m • 1 change

6h 18m • 1 change

6h 8m • 1 change

5h 10m • 1 change

5h 53m • 1 change

5h 15m • 1 change
Want to know about travelling from Manchester to Southwark? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Manchester to Southwark. However, there are services departing from Manchester station and arriving at Southwark station via Marble Arch. The journey, including transfers, takes approximately 5h 41m.
Manchester to Southwark bus services, operated by National Express, depart from Manchester Central Coach Station.
Manchester to Southwark bus services, operated by National Express, arrive at Marble Arch station.
The distance between Manchester and Southwark is 263.1 km. The road distance is 328 km.
National Express operates a bus from Manchester Central Coach Station to Marble Arch every 30 minutes. Tickets cost £35–90 and the journey takes 5h 40m.