The average bus between Manchester and Southwark takes 5h 28m and the fastest bus takes 5h 4m. There is a bus service every few hours from Manchester to Southwark. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Manchester and Southwark. The earliest departure is at 2:50 AM at night, and the last departure from Manchester is at 11:59 PM which arrives into Southwark at 6:38 AM. All services require a transfer at London Victoria and take an average of 5h 28m. The schedules shown below are for the next available departures.

5h 44m • 1 change

5h 31m • 1 change

5h 19m • 1 change

5h 17m • 1 change

5h 44m • 1 change

5h 31m • 1 change

5h 19m • 1 change

5h 17m • 1 change

5h 33m • 1 change

5h 28m • 1 change

5h 16m • 1 change

5h 14m • 1 change

5h 38m • 1 change

5h 21m • 1 change

5h 21m • 1 change

5h 16m • 1 change
Want to know about travelling from Manchester to Southwark? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Manchester to Southwark. However, there are services departing from Manchester station and arriving at Southwark station via London Victoria. The journey, including transfers, takes approximately 5h 28m.
Manchester to Southwark bus services, operated by FlixBus, depart from Manchester, Shudehill Interchange station.
Manchester to Southwark bus services, operated by FlixBus, arrive at London Victoria station.
The distance between Manchester and Southwark is 263.1 km. The road distance is 320 km.
FlixBus operates a bus from Manchester, Shudehill Interchange to London Victoria hourly. Tickets cost £19–35 and the journey takes 4h 40m.