The average train between Manchester and Southwark takes 2h 29m and the fastest train takes 2h 20m. The train runs at least 2 times per hour from Manchester to Southwark. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 30 minutes between Manchester and Southwark. The earliest departure is at 5:05 AM in the morning, and the last departure from Manchester is at 10:15 PM which arrives into Southwark at 1:27 AM. All services require a transfer at London Euston and take an average of 2h 29m. The schedules shown below are for the next available departures.

2h 31m • 1 change
Arrives next day

2h 56m • 1 change
Arrives next day

3h 12m • 1 change

2h 35m • 1 change

2h 30m • 1 change

2h 20m • 1 change

2h 31m • 1 change
Want to know about travelling from Manchester to Southwark? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Manchester to Southwark. However, there are services departing from Manchester station and arriving at Southwark station via London Euston. The journey, including transfers, takes approximately 2h 29m.
Manchester to Southwark train services, operated by Avanti West Coast, depart from Manchester Piccadilly station.
Manchester to Southwark train services, operated by Avanti West Coast, arrive at London Euston station.
Book your Manchester to Southwark train tickets online with Avanti West Coast and London Underground (Tube).
The distance between Manchester and Southwark is 263.1 km. The road distance is 297 km.
Avanti West Coast operates a train from Manchester Piccadilly to London Euston every 30 minutes. Tickets cost £65–110 and the journey takes 2h 8m.