The average bus between Manchester and Prestwick takes 6h 42m and the fastest bus takes 5h 53m. The bus service runs several times per day from Manchester to Prestwick. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Manchester and Prestwick. The earliest departure is at 2:10 AM at night, and the last departure from Manchester is at 5:20 PM which arrives into Prestwick at 12:10 AM. All services require a transfer, and take on average 6h 42m. The schedules shown below are for the next available departures.

6h 30m • 1 change

7h • 1 change
Arrives next day

6h 50m • 1 change

8h 3m • 1 change

7h • 1 change
Arrives next day

6h 50m • 1 change

5h 53m • 1 change

7h • 1 change
Arrives next day

6h 50m • 1 change

5h 53m • 1 change

7h • 1 change
Arrives next day

6h 50m • 1 change
Want to know about travelling from Manchester to Prestwick? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Manchester to Prestwick. However, there are services departing from Manchester station and arriving at Prestwick station via Buchanan Bus Station station. The journey, including transfers, takes approximately 6h 42m.
Manchester to Prestwick bus services, operated by FlixBus, depart from Shudehill Interchange station.
Manchester to Prestwick bus services, operated by FlixBus, arrive at Saunterne Road station.
Book your Manchester to Prestwick bus tickets online with FlixBus and Stagecoach West Scotland.
The distance between Manchester and Prestwick is 271.7 km. The road distance is 395 km.
You can take a bus from Shudehill Interchange to Saunterne Road via Buchanan Bus Station in around 5h 2m.