The average bus between Madison and St. Louis takes 11h 38m and the fastest bus takes 10h 10m. The bus service runs several times per day from Madison to St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Madison and St. Louis. The earliest departure is at 5:30 AM in the morning, and the last departure from Madison is at 5:30 PM which arrives into St. Louis at 6:25 AM. All services require a transfer at W Jackson Blvd, after S Clinton St and take an average of 11h 38m. The schedules shown below are for the next available departures.

10h 10m • 1 change

11h 20m • 1 change
Arrives next day

12h 55m • 1 change

10h 10m • 1 change

11h 20m • 1 change
Arrives next day

12h 55m • 1 change

10h 10m • 1 change

11h 20m • 1 change
Arrives next day

12h 55m • 1 change
Want to know about travelling from Madison to St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Madison to St. Louis. However, there are services departing from Madison station and arriving at St. Louis station via W Jackson Blvd, after S Clinton St. The journey, including transfers, takes approximately 11h 38m.
Madison to St. Louis bus services, operated by Vangalder Bus, depart from 250 N. Lake St - Madison UW Campus station.
Madison to St. Louis bus services, operated by Vangalder Bus, arrive at St Louis Bus Station.
Book your Madison to St. Louis bus tickets online with Vangalder Bus and Flixbus USA.
The distance between Madison and St. Louis is 498.9 km. The road distance is 764 km.
You can take a bus from 250 N. Lake St - Madison UW Campus to St Louis Bus Station via W Jackson Blvd, after S Clinton St and Chicago Bus Station in around 11h 2m.