Rome2Rio

How to get fromMadison to St. Louisby bus, train, bus (Flixbus, Greyhound), car, or plane

Find Transport to St. Louis

See all options

There are 8 ways to get from Madison to St. Louis by bus, train, bus (Flixbus, Greyhound), car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, train

    best
    1. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus Van Galder
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    9h 46m
    $111–246

  2. Drive 358.6 mi

    cheapest
    1. Drive from Madison to St. Louiscar car 358.6 mi
    5h 54m
    $66–95

  3. Bus

    1. Take the bus from Madison to Chicago Bus Stationbus bus FlixBus 2548 / ...
    2. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus 2510 / ...
    11h 5m
    $76–134

  4. Fly from Dane County Regional Airport-Truax Field

    1. Fly from Dane County Regional Airport-Truax Field (MSN) to Lambert–St. Louis International Airport (STL)plane plane MSN - STL
    5h 52m
    $105–655

  5. Bus, train via Milwaukee

    1. Take the bus from Madison, WI-Lake St. to Milwaukee, WI - Amtrakbus bus
    2. Take the train from Milwaukee to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    9h 50m
    $135–290

  6. Bus to General Mitchell International Airport, fly

    1. Take the bus from Madison, WI-Lake St. to Mitchell Airportbus bus
    2. Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane plane MKE - STL
    4h 58m
    $497–876

  7. Bus to Chicago O'Hare International Airport, fly

    1. Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 1 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    5h 57m
    $297–753

  8. Bus to Chicago Midway International Airport, fly

    1. Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 1 Departuresbus bus
    2. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    7h 18m
    $106–613

Madison to St. Louis by bus and train

Calendar38Weekly Services
Duration9h 46mAverage Duration
Ticket$111Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Madison to St. Louis.ExpandLaunch map view
  • Distance: 437.7 mi
  • Duration: 9h 46m

What companies run services between Madison, WI, USA and St. Louis, MO, USA?

You can take a bus from Madison to St Louis Bus Station via Chicago Bus Station in around 11h 5m. Alternatively, United Airlines, Delta, and American Airlines fly from Dane County Regional Airport-Truax Field (MSN) to Lambert–St. Louis International Airport (STL) hourly.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There