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How to get fromMadison to St. Louisby plane, bus, train, bus (Flixbus) or car

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There are 8 ways to get from Madison to St. Louis by plane, bus, train, bus (Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Dane County Regional Airport-Truax Field

    best
    1. Fly from Dane County Regional Airport-Truax Field (MSN) to Lambert–St. Louis International Airport (STL)planeMSN - STL
    5h 41m
    $115–705

  2. Bus

    cheapest
    1. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton StbusVan Galder
    2. Take the bus from Chicago Bus Station to St Louis Bus StationbusFlixBus N2521 / ...
    11h 17m
    $57–136

  3. Bus, train

    1. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton StbusVan Galder
    2. Take the train from Chicago Union Station to St. LouistrainLincoln Service / ...
    9h 46m
    $62–291

  4. Drive 358.5 mi

    1. Drive from Madison to St. Louiscar358.5 mi
    5h 50m
    $66–95

  5. Bus to General Mitchell International Airport, fly

    1. Take the bus from Madison, WI-Lake St. to Mitchell Airportbus
    2. Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)planeMKE - STL
    5h 3m
    $274–506

  6. Bus to Chicago O'Hare International Airport, fly

    1. Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 1 Departuresbus
    2. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)planeORD - STL
    6h 2m
    $193–543

  7. Bus to Chicago Midway International Airport, fly

    1. Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 1 Departuresbus
    2. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)planeMDW - STL
    7h 22m
    $102–603

  8. Bus, train via Milwaukee

    1. Take the bus from Madison, WI-Lake St. to Milwaukee, WI - Amtrakbus
    2. Take the train from Milwaukee to Chicago Union Stationtrain
    3. Take the train from Chicago Union Station to St. Louistrain
    9h 50m
    $69–349

Madison to St. Louis by bus and train

Calendar38Weekly Services
Duration9h 46mAverage Duration
Ticket$62Cheapest Price
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Questions & Answers

What companies run services between Madison, WI, USA and St. Louis, MO, USA?

American Airlines, United Airlines, and Delta fly from Dane County Regional Airport-Truax Field (MSN) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a bus from 250 N. Lake St - Madison UW Campus to St Louis Bus Station via W Jackson Blvd, after S Clinton St and Chicago Bus Station in around 11h 17m.

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