The average bus between Lyon and Santander takes 15h 25m and the fastest bus takes 14h 30m. There is at least one bus per day from Lyon to Santander. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run once daily between Lyon and Santander. The earliest departure is at 1:15 PM in the afternoon, and the last departure from Lyon is at 7:50 PM which arrives into Santander at 12:30 PM. All services require a transfer at Bilbao and take an average of 15h 25m. The schedules shown below are for the next available departures.
Arrives next day

18h 45m • 1 change
Arrives next day

16h 40m • 1 change
Arrives next day

18h 45m • 1 change
Arrives next day

16h 40m • 1 change
Want to know about travelling from Lyon to Santander? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Lyon to Santander. However, there are services departing from Lyon station and arriving at Santander station via Bilbao. The journey, including transfers, takes approximately 15h 25m.
Lyon to Santander bus services, operated by FlixBus, depart from Lyon station.
Lyon to Santander bus services, operated by FlixBus, arrive at Santander E.A. station.
Book your Lyon to Santander bus tickets online with FlixBus and ALSA.
The distance between Lyon and Santander is 730 km. The road distance is 964 km.
You can take a bus from Lyon to Santander E.A. via Bilbao and Bilbao Intermodal in around 14h 22m.