The average bus between Lyon and Pisa takes 13h and the fastest bus takes 12h 30m. The bus service runs several times per day from Lyon to Pisa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Lyon and Pisa. The earliest departure is at 1:15 AM at night, and the last departure from Lyon is at 10:50 AM which arrives into Pisa at 12:50 AM. All services require a transfer, and take on average 13h. The schedules shown below are for the next available departures.

12h 35m • 1 change

12h 30m • 1 change
Arrives next day

14h • 1 change

12h 35m • 1 change

12h 30m • 1 change
Arrives next day

14h • 1 change

12h 35m • 1 change

12h 30m • 1 change
Arrives next day

14h • 1 change
Want to know about travelling from Lyon to Pisa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Lyon to Pisa. However, there are services departing from Lyon station and arriving at Pisa station via Florence Villa Constanza Bus Station station. The journey, including transfers, takes approximately 13h.
Lyon to Pisa bus services, operated by BlaBlaCar Bus, depart from Lyon station.
Lyon to Pisa bus services, operated by BlaBlaCar Bus, arrive at Pisa station.
Book your Lyon to Pisa bus tickets online with BlaBlaCar Bus and FlixBus.
The distance between Lyon and Pisa is 494 km. The road distance is 812 km.
You can take a bus from Lyon to Pisa via Florence Villa Constanza Bus Station in around 12h 15m.