The average bus between Luton and Southampton takes 3h 39m and the fastest bus takes 2h 35m. The bus service runs several times per day from Luton to Southampton. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 3 hours between Luton and Southampton. The earliest departure is at 4:45 AM at night, and the last departure from Luton is at 10:25 PM which arrives into Southampton at 1:00 AM. All services require a transfer, and take on average 3h 39m. The schedules shown below are for the next available departures.

4h 45m • 1 change

3h 35m • 1 change

3h 35m • 1 change

3h 25m • 1 change

5h 5m • 1 change

3h 35m • 1 change

3h 35m • 1 change

3h 15m • 1 change

5h 5m • 1 change

3h 35m • 1 change

3h 35m • 1 change

3h 15m • 1 change

4h 20m • 1 change

3h 35m • 1 change

3h 35m • 1 change

3h 15m • 1 change

4h • 1 change

3h 35m • 1 change

3h 35m • 1 change

3h 15m • 1 change

4h • 1 change

3h 35m • 1 change

3h 35m • 1 change

3h 15m • 1 change
Want to know about travelling from Luton to Southampton? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Luton to Southampton. However, there are services departing from Luton station and arriving at Southampton station via London Heathrow Airport. The journey, including transfers, takes approximately 3h 39m.
Luton to Southampton bus services, operated by FlixBus, depart from Luton DART Parkway station.
Luton to Southampton bus services, operated by FlixBus, arrive at Coach Station.
The distance between Luton and Southampton is 128.3 km. The road distance is 164 km.
You can take a bus from Luton DART Parkway to Coach Station via Heathrow Central Bus Station in around 3h 44m.