The average bus between Luton and Southampton takes 3h 37m and the fastest bus takes 3h 5m. The bus service runs several times per day from Luton to Southampton. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 3 hours between Luton and Southampton. The earliest departure is at 5:45 AM in the morning, and the last departure from Luton is at 6:45 PM which arrives into Southampton at 9:50 PM. All services require a transfer, and take on average 3h 37m. The schedules shown below are for the next available departures.

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Want to know about travelling from Luton to Southampton? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Luton to Southampton. However, there are services departing from Luton station and arriving at Southampton station via Heathrow Central Bus Station station. The journey, including transfers, takes approximately 3h 37m.
Luton to Southampton bus services, operated by National Express, depart from Luton Station Interchange.
Luton to Southampton bus services, operated by National Express, arrive at Coach Station.
Book your Luton to Southampton bus tickets online with National Express.
The distance between Luton and Southampton is 128.3 km. The road distance is 168 km.
You can take a bus from Luton Station Interchange to Coach Station via Heathrow Central Bus Station in around 3h 27m.