There are 9 ways to get from Isernia to Sicily by train, plane, car, ferry, bus, or train (Trenitalia)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train to Naples Airport, fly to Catania–Fontanarossa Airport
best- Take the train from Isernia to Caserta
- Fly from Naples Airport (NAP) to Catania–Fontanarossa Airport (CTA)NAP - CTA
4h 57m€34–150Bus
cheapest- Take the bus from Isernia to Napoli, Autostazione Metropark6
- Take the bus from Napoli, Autostazione Metropark to Palermo Terminal BusItabus
13h 53m€26–39Drive, ferry
- Drive from Isernia to Port of Naples
- Take the ferry from Port of Naples to Port of Palermo
10h 7m€58–80Bus via Caserta
- Take the bus from Isernia to Caserta Terminal Bus433
- Take the bus from Caserta Viale Vittorio Veneto to Palermo Via Tommaso FazelloAutoservizi Salemi S201
12h 33m€33–52Train
- Take the train from Isernia to CassinoRe
- Take the train from Cassino to Palermo CentraleIc
12h 48m€52–71Train to Naples Airport, fly to Palermo Airport
- Take the train from Isernia to Caserta
- Fly from Naples Airport (NAP) to Palermo Airport (PMO)NAP - PMO
5h 24m€36–142Train to Fiumicino International Airport, fly to Catania–Fontanarossa Airport
- Take the train from Isernia to Roma Termini
- Fly from Fiumicino International Airport (FCO) to Catania–Fontanarossa Airport (CTA)FCO - CTA
5h 41m€46–186Train to Fiumicino International Airport, fly to Vincenzo Magliocco Airport
- Take the train from Isernia to Roma Termini
- Fly from Fiumicino International Airport (FCO) to Vincenzo Magliocco Airport (CIY)FCO - CIY
5h 34m€68–264Train to Fiumicino International Airport, fly to Palermo Airport
- Take the train from Isernia to Roma Termini
- Fly from Fiumicino International Airport (FCO) to Palermo Airport (PMO)FCO - PMO
6h 9m€48–208
Isernia to Sicily by bus
Questions & Answers
The cheapest way to get from Isernia to Sicily is to bus which costs €25 - €40 and takes 13h 53m.
The fastest way to get from Isernia to Sicily is to train and fly which takes 4h 57m and costs €30 - €150.
No, there is no direct bus from Isernia to Sicily. However, there are services departing from Isernia and arriving at Piazza Boiardo via Caserta Viale Vittorio Veneto and Stazione Centrale Pensilina Esterna. The journey, including transfers, takes approximately 12h 33m.
No, there is no direct train from Isernia to Sicily. However, there are services departing from Isernia and arriving at Palermo Notarbartolo via Cassino and Palermo Centrale. The journey, including transfers, takes approximately 12h 48m.
The distance between Isernia and Sicily is 508 km.
The best way to get from Isernia to Sicily without a car is to bus via Caserta which takes 12h 33m and costs €30 - €55.
It takes approximately 4h 57m to get from Isernia to Sicily, including transfers.
Isernia to Sicily bus services, operated by FlixBus, depart from Isernia station.
Isernia to Sicily train services, operated by Trenitalia S.p.A., depart from Isernia station.
The best way to get from Isernia to Sicily is to bus via Caserta which takes 12h 33m and costs €30 - €55. Alternatively, you can train, which costs €50 - €75 and takes 12h 48m.
What companies run services between Isernia, Italy and Sicily, Italy?
You can take a bus from Isernia to Piazza Boiardo via Caserta Terminal Bus, Caserta Viale Vittorio Veneto, Palermo Via Tommaso Fazello, and Stazione Centrale Pensilina Esterna in around 12h 33m. Alternatively, you can take a train from Isernia to Palermo Notarbartolo via Cassino and Palermo Centrale in around 12h 48m.
- Website
- ryanair.com
Flights from Naples Airport to Catania–Fontanarossa Airport
- Ave. Duration
- 1h 10m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €35–150
Flights from Naples Airport to Palermo Airport
- Ave. Duration
- 1h
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €30–170
Flights from Fiumicino International Airport to Catania–Fontanarossa Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €28–130
Flights from Fiumicino International Airport to Palermo Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €30–140
- Website
- aeroitalia.com
Flights from Fiumicino International Airport to Catania–Fontanarossa Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €28–280
Flights from Fiumicino International Airport to Vincenzo Magliocco Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- €30–450
Flights from Fiumicino International Airport to Palermo Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €29–270
- Website
- flexflight.dk
Flights from Fiumicino International Airport to Catania–Fontanarossa Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €28–280
Flights from Fiumicino International Airport to Vincenzo Magliocco Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- €30–450
Flights from Fiumicino International Airport to Palermo Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €29–270
- Website
- ita-airways.com
Flights from Fiumicino International Airport to Catania–Fontanarossa Airport
- Ave. Duration
- 1h 17m
- When
- Every day
- Estimated price
- €40–120
Flights from Fiumicino International Airport to Palermo Airport
- Ave. Duration
- 1h 8m
- When
- Every day
- Estimated price
- €35–130
- Website
- easyjet.com
Flights from Naples Airport to Catania–Fontanarossa Airport
- Ave. Duration
- 1h 5m
- When
- Every day
- Estimated price
- €23–110
Flights from Naples Airport to Palermo Airport
- Ave. Duration
- 55 min
- When
- Every day
- Estimated price
- €23–120
- Website
- volotea.com
Flights from Naples Airport to Palermo Airport
- Ave. Duration
- 1h
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- €23–95
- Website
- tuifly.be
Flights from Naples Airport to Palermo Airport
- Ave. Duration
- 1h 20m
- When
- Friday
- Estimated price
- €85–250
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Isernia to Caserta
- Ave. Duration
- 1h 10m
- Frequency
- Every 4 hours
- Estimated price
- €6–10
- Website
- https://www.trenitalia.com/en.html
Train from Isernia to Cassino
- Ave. Duration
- 44 min
- Frequency
- Every 3 hours
- Estimated price
- €4–7
- Website
- https://www.trenitalia.com/en.html
Train from Isernia to Roma Termini
- Ave. Duration
- 2h 22m
- Frequency
- Every 4 hours
- Estimated price
- €11–17
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Cassino to Palermo Centrale
- Ave. Duration
- 10h 29m
- Frequency
- Once daily
- Estimated price
- €45–60
- Website
- https://www.trenitalia.com/en.html
- 2nd Class
- €45–60
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Isernia to Caserta Terminal Bus
- Ave. Duration
- 1h 15m
- Frequency
- Twice daily
- Estimated price
- €7–16
- Website
- https://www.flixbus.co.uk
- Phone
- (+39) 0923 98.11.20
- Website
- autoservizisalemi.it
Bus from Caserta Viale Vittorio Veneto to Palermo Via Tommaso Fazello
- Ave. Duration
- 9h 45m
- Frequency
- Once daily
- Estimated price
- €24–35
- Schedules at
- autoservizisalemi.it
- Phone
- 0865.221788
- info@satiautobus.com
- Website
- satiautobus.com
Bus from Isernia to Napoli, Autostazione Metropark
- Ave. Duration
- 1h 50m
- Frequency
- 3 times a day
- Estimated price
- €4–10
- Schedules at
- satiautobus.com
- Phone
- +39 06 88 93 82 32
- Website
- itabus.it
Bus from Napoli, Autostazione Metropark to Palermo Terminal Bus
- Ave. Duration
- 10h 30m
- Frequency
- 3 times a week
- Estimated price
- €19–27
- Website
- https://www.itabus.it/en/home
- Phone
- +39.081.496.444
- info@grimaldi.napoli.it
- Website
- grimaldi-lines.com
Ferry from Port of Naples to Port of Palermo
- Ave. Duration
- 8h 30m
- Frequency
- Once daily
- Estimated price
- €40–55
- Website
- https://www.grimaldi-lines.com/en/
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More Questions & Answers
Isernia to Sicily bus services, operated by FlixBus, arrive at Caserta Terminal Bus station.
Isernia to Sicily train services, operated by Trenitalia S.p.A., arrive at Cassino station.
Book your Isernia to Sicily train tickets online with Omio.
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