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There are 9 ways to get from Isernia to Sicily by car, car ferry, bus, train, bus and ferry or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Drive, car ferry  •  11h

  1. Drive from Isernia to Naples
  2. Take the car ferry from Naples to Termini Imerese

€43 - €84

Cheapest option

Bus to Rome, fly to Catania  •  6h 41m

  1. Take the bus from Isernia to Roma Tiburtina
  2. Fly from Rome (FCO) to Catania (CTA) FCO - CTA

€23 - €123

7 alternative options

Bus, train  •  13h 42m

  1. Take the bus from Isernia to Cassino Piazza Garibaldi Cb 015
  2. Take the train from Cassino to Palermo Centrale Ic

€50 - €71

Bus, car ferry  •  14h 32m

  1. Take the bus from Isernia to NapoIi - Bus Metropark 6
  2. Take the car ferry from Naples to Palermo

€32 - €69

Bus, bus and ferry  •  17h 56m

  1. Take the bus from Isernia to Foggia 565
  2. Take the bus and ferry from Foggia to Palermo San Giovanni Rotondo - Palermo

€42 - €79

Bus to Naples, fly to Catania  •  5h 26m

  1. Take the bus from Isernia to NapoIi - Bus Metropark
  2. Fly from Naples (NAP) to Catania (CTA) NAP - CTA

€25 - €108

Bus to Naples, fly to Palermo  •  5h 48m

  1. Take the bus from Isernia to NapoIi - Bus Metropark
  2. Fly from Naples (NAP) to Palermo (PMO) NAP - PMO

€27 - €114

Bus to Rome, fly to Palermo  •  6h 53m

  1. Take the bus from Isernia to Roma Tiburtina
  2. Fly from Rome (FCO) to Palermo (PMO) FCO - PMO

€30 - €164

Bus to Pescara, fly to Trapani  •  7h 14m

  1. Take the bus from Isernia to Pescara
  2. Fly from Pescara (PSR) to Trapani (TPS) PSR - TPS

€42 - €112

Isernia to Sicily by bus, walk and car ferry

The journey time between Isernia and Sicily is around 16h 21m and covers a distance of around 434 km. The fastest journey normally takes 16h 8m. Operated by Società Autocooperative Trasporti Italiani S.p.A., Azienda Napoletana Mobilita, Tirrenia and others, the Isernia to Sicily service departs from Isernia and arrives in Leonardo Da Vinci - Galilei. Typically five services run weekly, although weekend and holiday schedules can vary so check in advance.

Route overview

Average journey time:
16h 21m
Fastest journey time:
16h 8m
Journey distance:
434 km
Services per week:
5
Cheapest price:
€43
Carbon emissions:
63 kg CO2

First and last service

First service departs at:
14:55
Last service departs at:
14:55

The schedules shown below are for the next available departures.

Isernia to Sicily bus, walk and car ferry schedules

Bus services typically run at the following times each day These schedules are estimated
Estimated schedules: These schedules are estimated and based on typical services on an average day. Please check times and availability with the operator before travelling.
Isernia → Sicily
Partially open

Travel safe during COVID-19

Rules to follow in Italy

1.5m

Mandatory

Mandatory

Travel within Italy

Observe COVID-19 safety rules
Nationwide control measures in place
Inter-regional travel is permitted

COVID-19 help in Italy

If you need help, visit the national COVID-19 website or call the COVID-19 Helpline 1500

Frequently Asked Questions


There are currently travel restrictions within Italy.

Explore options for future travel

Domestic travel is not restricted, but some conditions may apply

  • Face masks are mandatory
  • There is a social distancing requirement of 1.5 metres
  • Observe COVID-19 safety rules
  • Nationwide control measures in place
  • Inter-regional travel is permitted

Explore travel options

The national COVID-19 helpline number in Sicily is 1500.

Wearing a face mask on public transport in Sicily is mandatory.

The social distance requirement in Sicily is 1.5 metres.

Make yourself known to an official member of staff and/or call the national coronavirus helpline number on 1500.

Last updated: 2 Aug 2021
Exceptions may apply, for full details: European Union.

We're working around the clock to bring you the latest COVID-19 travel updates.
This information is compiled from official sources. To the best of our knowledge, it is correct as of the last update.
Visit Rome2rio travel advice for general help.

Questions & Answers

The cheapest way to get from Isernia to Sicily is to bus and fly which costs €23 - €130 and takes 6h 41m.

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The quickest way to get from Isernia to Sicily is to bus and fly which costs €24 - €110 and takes 5h 26m.

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No, there is no direct bus from Isernia to Sicily. However, there are services departing from Isernia and arriving at Piazza Boiardo via Foggia and Stazione Centrale - Pensilina Esterna. The journey, including transfers, takes approximately 17h 56m.

More details

The distance between Isernia and Sicily is 446 km.

The best way to get from Isernia to Sicily without a car is to bus and train which takes 13h 42m and costs €50 - €75.

More details

It takes approximately 11h to get from Isernia to Sicily, including transfers.

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Isernia to Sicily bus services, operated by FlixBus, depart from Isernia station.

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The quickest flight from Naples Airport to Catania Airport is the direct flight which takes 1h.

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Isernia to Sicily bus services, operated by Autoservizi Salemi Srl, arrive at Palermo station.

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Ryanair, Volotea, Alitalia and easyJet offer flights from Naples Airport to Catania Airport.

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Map of how to get from Isernia to Sicily.
Launch map view
  • Distance: 445.7 km
  • Duration: 11h

What companies run services between Isernia, Italy and Sicily, Italy?

There is no direct connection from Isernia to Sicily. However, you can take the drive to Naples, take the car ferry to Termini Imerese, then take the drive to Palermo. Alternatively, you can take a vehicle from Isernia to Palermo via Cassino Piazza Garibaldi, Cassino, Palermo Centrale, and Stazione Centrale - Pensilina Esterna in around 13h 42m.

Airlines
Ryanair
Website
ryanair.com
Flights from Naples to Catania
Ave. Duration
1h 5m
When
Wednesday, Friday and Sunday
Estimated price
€17 - €150
Flights from Naples to Palermo
Ave. Duration
1h
When
Monday, Friday and Sunday
Estimated price
€20 - €130
Flights from Rome to Palermo
Ave. Duration
1h 5m
When
Every day
Estimated price
€15 - €150
Flights from Rome to Catania
Ave. Duration
1h 15m
When
Every day
Estimated price
€5 - €120
Flights from Pescara to Trapani
Ave. Duration
1h 15m
When
Thursday, Friday and Sunday
Estimated price
€30 - €200
Alitalia
Website
alitalia.com
Flights from Naples to Catania via Rome
Ave. Duration
3h
When
Every day
Estimated price
€55 - €240
Flights from Rome to Palermo
Ave. Duration
1h 7m
When
Every day
Estimated price
€35 - €220
Flights from Rome to Catania
Ave. Duration
1h 15m
When
Every day
Estimated price
€30 - €160
easyJet
Website
easyjet.com
Flights from Naples to Catania
Ave. Duration
1h 1m
When
Every day
Estimated price
€35 - €160
Flights from Naples to Palermo
Ave. Duration
1h
When
Every day
Estimated price
€35 - €140
Volotea
Website
volotea.com
Flights from Naples to Catania
Ave. Duration
1h 10m
When
Every day
Estimated price
€22 - €160
Flights from Naples to Palermo
Ave. Duration
1h
When
Every day
Estimated price
€24 - €150
Wizz Air
Website
wizzair.com
Flights from Rome to Catania
Ave. Duration
1h 15m
When
Every day
Estimated price
€4 - €100
TUI fly Belgium
Website
tuifly.be
Flights from Naples to Palermo
Ave. Duration
1h
When
Friday
Estimated price
€25 - €100
Tayaran Jet
Website
en.tayaranjet.com
Flights from Pescara to Trapani
Ave. Duration
1h 20m
When
Thursday and Sunday
Estimated price
€30 - €550
Train operators
Trenitalia Intercity

Trenitalia’s Intercity (IC) trains are slower than the high-speed Frecce trains but are still a good way to travel between major cities and towns, with routes including Rome to Naples, Venice to Bologna and Milan to Genoa. Tickets usually open for booking 90 days ahead of travel, and you’ll need make a seat reservation before boarding. All IC trains have 1st and 2nd class carriages as well as a bar buffet car, air conditioning and power sockets. InterCity trains that run at night are called InterCity Notte (ICN).

Contact Details
Phone
+39 06 68475475
Website
trenitalia.com
Train from Cassino to Palermo Centrale
Ave. Duration
11h 9m
Frequency
3 times a week
Estimated price
€45 - €65
Website
Trenitalia Intercity
2nd Class
€45 - €65
Bus operators
ATM Azienda di Trasporti Molisana S.p.A.
Phone
+39 0874 64744
Email
info@atm-molise.it
Website
atm-molise.it
Bus from Isernia to Cassino Piazza Garibaldi
Ave. Duration
57 min
Frequency
3 times a day
Estimated price
€2 - €4
Schedules at
atm-molise.it
Bus from Isernia to Roma Tiburtina
Ave. Duration
2h 10m
Frequency
Twice daily
Estimated price
€9 - €13
Schedules at
atm-molise.it
Bus from Isernia to Pescara
Ave. Duration
2h 15m
Frequency
Twice daily
Estimated price
€8 - €12
Schedules at
atm-molise.it
Società Autocooperative Trasporti Italiani S.p.A.
Phone
0874.63999
Email
info@satiautobus.com
Website
satiautobus.com
Bus from Isernia to NapoIi - Bus Metropark
Ave. Duration
1h 50m
Frequency
3 times a day
Estimated price
€4 - €10
Schedules at
satiautobus.com
FlixBus

One of Europe’s leading bus companies, Flixbus serves 2000+ destinations in 29 countries, including Germany, France, Italy, Austria, the Netherlands and Croatia and into Scandinavia and eastern Europe, as well as some US cities. Coaches have toilets, free WiFi and power outlets, plus snacks and drinks for purchase on board. Flixbus is a good choice for the budget-conscious traveller; purchase tickets in advance for the cheapest fares (note: there is no option to reserve a seat in advance).

Rome2rio's guide to FlixBus
Contact Details
Phone
+49 1807 123 99 123
Email
info@flixbus.de
Website
flixbus.de
Bus from Isernia to Foggia
Ave. Duration
2h 10m
Frequency
5 times a week
Estimated price
€9 - €12
Website
flixbus.co.uk
Autoservizi Salemi Srl
Phone
(+39) 0923 98.11.20
Website
autoservizisalemi.it
Bus and ferry from Foggia to Palermo
Ave. Duration
14h 10m
Frequency
Once daily
Estimated price
€30 - €65
Schedules at
autoservizisalemi.it
Ferry operators
Grandi Navi Veloci
Phone
+39 010 209 4591
Email
booking@gnv.it
Website
gnv.it
Car ferry from Naples to Termini Imerese
Ave. Duration
9h
Frequency
4 times a week
Estimated price
€24 - €55
Website
Grandi Navi Veloci
Car ferry from Naples to Palermo
Ave. Duration
11h
Frequency
Once daily
Estimated price
€24 - €55
Website
Grandi Navi Veloci
Tirrenia
Phone
+49 611–14020
Email
info@tirrenia.de
Website
tirrenia.it
Car ferry from Naples to Palermo
Ave. Duration
10h 30m
Frequency
Once daily
Estimated price
€35 - €45
Website
Tirrenia

Want to know more about travelling around Italy

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

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