There are 9 ways to get from Isernia to Sicily by train, plane, car, car ferry, bus, or train (Trenitalia)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train to Naples Airport, fly to Catania–Fontanarossa Airport
best- Take the train from Isernia to Napoli Centraletrain
- Fly from Naples Airport (NAP) to Catania–Fontanarossa Airport (CTA)plane NAP - CTA
4h 47m€38–163Bus
cheapest- Take the bus from Isernia to Napoli, Autostazione Metroparkbus 6
- Take the bus from Napoli, Autostazione Metropark to Palermo Terminal Busbus Itabus
13h 57m€31–47Drive, car ferry
- Drive from Isernia to Port of Naplescar
- Take the car ferry from Port of Naples to Port of Palermocarferry
10h 8m€58–95Bus via Caserta
- Take the bus from Isernia to Caserta Terminal Busbus 433
- Take the bus from Caserta Viale Vittorio Veneto to Palermo Via Tommaso Fazellobus Autoservizi Salemi S201
12h 37m€36–62Train (Trenitalia)
- Take the train from Isernia to Cassinotrain Re
- Take the train from Cassino to Palermo Centraletrain Ic
13h 25m€73–98Train to Naples Airport, fly to Palermo Airport
- Take the train from Isernia to Napoli Centraletrain
- Fly from Naples Airport (NAP) to Palermo Airport (PMO)plane NAP - PMO
5h 17m€39–155Train to Fiumicino International Airport, fly to Catania–Fontanarossa Airport
- Take the train from Isernia to Roma Terminitrain
- Fly from Fiumicino International Airport (FCO) to Catania–Fontanarossa Airport (CTA)plane FCO - CTA
5h 40m€52–192Train to Fiumicino International Airport, fly to Vincenzo Magliocco Airport
- Take the train from Isernia to Roma Terminitrain
- Fly from Fiumicino International Airport (FCO) to Vincenzo Magliocco Airport (CIY)plane FCO - CIY
5h 37m€84–230Train to Fiumicino International Airport, fly to Palermo Airport
- Take the train from Isernia to Roma Terminitrain
- Fly from Fiumicino International Airport (FCO) to Palermo Airport (PMO)plane FCO - PMO
6h 15m€54–214
Isernia to Sicily by bus
Questions & Answers
The cheapest way to get from Isernia to Sicily is to bus which costs €30 - €50 and takes 13h 57m.
The fastest way to get from Isernia to Sicily is to train and fly which takes 4h 47m and costs €35 - €170.
No, there is no direct bus from Isernia to Sicily. However, there are services departing from Isernia and arriving at Piazza Boiardo via Caserta Viale Vittorio Veneto and Stazione Centrale Pensilina Esterna. The journey, including transfers, takes approximately 12h 37m.
The distance between Isernia and Sicily is 519 km.
The best way to get from Isernia to Sicily without a car is to bus via Caserta which takes 12h 37m and costs €35 - €65.
It takes approximately 4h 47m to get from Isernia to Sicily, including transfers.
Isernia to Sicily bus services, operated by FlixBus, depart from Isernia station.
The best way to get from Isernia to Sicily is to bus via Caserta which takes 12h 37m and costs €35 - €65. Alternatively, you can train, which costs €70 - €100 and takes 13h 25m.
Isernia to Sicily bus services, operated by FlixBus, arrive at Caserta Terminal Bus station.
There are 5768+ hotels available in Sicily.
What companies run services between Isernia, Italy and Sicily, Italy?
You can take a bus from Isernia to Piazza Boiardo via Caserta Terminal Bus, Caserta Viale Vittorio Veneto, Palermo Via Tommaso Fazello, and Stazione Centrale Pensilina Esterna in around 12h 37m. Alternatively, you can take a train from Isernia to Piazza Boiardo via Cassino, Palermo Centrale, and Stazione Centrale Pensilina Esterna in around 13h 25m.
- Website
- ryanair.com
Flights from Naples Airport to Catania–Fontanarossa Airport
- Ave. Duration
- 1h 10m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €35–140
Flights from Naples Airport to Palermo Airport
- Ave. Duration
- 1h
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €40–110
Flights from Fiumicino International Airport to Catania–Fontanarossa Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €24–120
Flights from Fiumicino International Airport to Palermo Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €28–140
- Website
- aeroitalia.com
Flights from Fiumicino International Airport to Catania–Fontanarossa Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €35–140
Flights from Fiumicino International Airport to Vincenzo Magliocco Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- €45–280
Flights from Fiumicino International Airport to Palermo Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €35–210
- Website
- flexflight.dk
Flights from Fiumicino International Airport to Catania–Fontanarossa Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €35–140
Flights from Fiumicino International Airport to Vincenzo Magliocco Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- €45–280
Flights from Fiumicino International Airport to Palermo Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €35–210
- Website
- ita-airways.com
Flights from Fiumicino International Airport to Catania–Fontanarossa Airport
- Ave. Duration
- 1h 18m
- When
- Every day
- Estimated price
- €35–110
Flights from Fiumicino International Airport to Palermo Airport
- Ave. Duration
- 1h 8m
- When
- Every day
- Estimated price
- €35–120
- Website
- easyjet.com
Flights from Naples Airport to Catania–Fontanarossa Airport
- Ave. Duration
- 1h 5m
- When
- Every day
- Estimated price
- €21–100
Flights from Naples Airport to Palermo Airport
- Ave. Duration
- 55 min
- When
- Every day
- Estimated price
- €20–100
- Website
- volotea.com
Flights from Naples Airport to Palermo Airport
- Ave. Duration
- 1h
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- €20–90
- Website
- tuifly.be
Flights from Naples Airport to Palermo Airport
- Ave. Duration
- 1h 20m
- When
- Friday
- Estimated price
- €75–250
- Website
- neosair.it
Flights from Fiumicino International Airport to Catania–Fontanarossa Airport
- Ave. Duration
- 1h 10m
- When
- Saturday
- Estimated price
- €130–330
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Isernia to Napoli Centrale
- Ave. Duration
- 2h 5m
- Frequency
- 4 times a day
- Estimated price
- €9–35
- Website
- https://www.trenitalia.com/en.html
Train from Isernia to Cassino
- Ave. Duration
- 40 min
- Frequency
- Every 4 hours
- Estimated price
- €5–6
- Website
- https://www.trenitalia.com/en.html
Train from Isernia to Roma Termini
- Ave. Duration
- 2h 25m
- Frequency
- 5 times a day
- Estimated price
- €13–50
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Cassino to Palermo Centrale
- Ave. Duration
- 11h 8m
- Frequency
- Twice a week
- Estimated price
- €65–90
- Website
- https://www.trenitalia.com/en.html
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Isernia to Caserta Terminal Bus
- Ave. Duration
- 1h 15m
- Frequency
- Once daily
- Estimated price
- €5–16
- Website
- https://www.flixbus.co.uk
- Phone
- (+39) 0923 98.11.20
- Website
- autoservizisalemi.it
Bus from Caserta Viale Vittorio Veneto to Palermo Via Tommaso Fazello
- Ave. Duration
- 9h 45m
- Frequency
- Once daily
- Estimated price
- €29–45
- Schedules at
- autoservizisalemi.it
- Phone
- 0865.221788
- info@satiautobus.com
- Website
- satiautobus.com
Bus from Isernia to Napoli, Autostazione Metropark
- Ave. Duration
- 1h 50m
- Frequency
- 3 times a day
- Estimated price
- €4–10
- Schedules at
- satiautobus.com
- Phone
- +39 06 88 93 82 32
- Website
- itabus.it
Bus from Napoli, Autostazione Metropark to Palermo Terminal Bus
- Ave. Duration
- 10h 30m
- Frequency
- 3 times a week
- Estimated price
- €24–35
- Website
- https://www.itabus.it/en/home
- Phone
- +39.081.496.444
- info@grimaldi.napoli.it
- Website
- grimaldi-lines.com
Car ferry from Port of Naples to Port of Palermo
- Ave. Duration
- 8h 30m
- Frequency
- Once daily
- Estimated price
- €40–55
- Website
- https://www.grimaldi-lines.com/en/
- Phone
- +39 010 209 4591
- booking@gnv.it
- Website
- gnv.it
Car ferry from Port of Naples to Port of Palermo
- Ave. Duration
- 12h
- Frequency
- Once daily
- Estimated price
- €45–70
- Website
- https://www.gnv.it/en
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