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How to get fromIsernia to Sicilyby train, plane, car, ferry, bus or train (Trenitalia)

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There are 9 ways to get from Isernia to Sicily by train, plane, car, ferry, bus, or train (Trenitalia)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Naples Airport, fly to Catania–Fontanarossa Airport

    best
    1. Take the train from Isernia to Casertatrain
    2. Fly from Naples Airport (NAP) to Catania–Fontanarossa Airport (CTA)planeNAP - CTA
    4h 57m
    €34–150
  2. Bus

    cheapest
    1. Take the bus from Isernia to Napoli, Autostazione Metroparkbus6
    2. Take the bus from Napoli, Autostazione Metropark to Palermo Terminal BusbusItabus
    13h 53m
    €26–39
  3. Drive, ferry

    1. Drive from Isernia to Port of Naplescar
    2. Take the ferry from Port of Naples to Port of Palermoferry
    10h 7m
    €58–80
  4. Bus via Caserta

    1. Take the bus from Isernia to Caserta Terminal Busbus433
    2. Take the bus from Caserta Viale Vittorio Veneto to Palermo Via Tommaso FazellobusAutoservizi Salemi S201
    12h 33m
    €33–52
  5. Train

    1. Take the train from Isernia to CassinotrainRe
    2. Take the train from Cassino to Palermo CentraletrainIc
    12h 48m
    €52–71
  6. Train to Naples Airport, fly to Palermo Airport

    1. Take the train from Isernia to Casertatrain
    2. Fly from Naples Airport (NAP) to Palermo Airport (PMO)planeNAP - PMO
    5h 24m
    €36–142
  7. Train to Fiumicino International Airport, fly to Catania–Fontanarossa Airport

    1. Take the train from Isernia to Roma Terminitrain
    2. Fly from Fiumicino International Airport (FCO) to Catania–Fontanarossa Airport (CTA)planeFCO - CTA
    5h 41m
    €46–186
  8. Train to Fiumicino International Airport, fly to Vincenzo Magliocco Airport

    1. Take the train from Isernia to Roma Terminitrain
    2. Fly from Fiumicino International Airport (FCO) to Vincenzo Magliocco Airport (CIY)planeFCO - CIY
    5h 34m
    €68–264
  9. Train to Fiumicino International Airport, fly to Palermo Airport

    1. Take the train from Isernia to Roma Terminitrain
    2. Fly from Fiumicino International Airport (FCO) to Palermo Airport (PMO)planeFCO - PMO
    6h 9m
    €48–208

Isernia to Sicily by bus

Calendar7Weekly Buses
Duration12h 33mAverage Duration
Ticket€33Cheapest Price
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Questions & Answers

What companies run services between Isernia, Italy and Sicily, Italy?

You can take a bus from Isernia to Piazza Boiardo via Caserta Terminal Bus, Caserta Viale Vittorio Veneto, Palermo Via Tommaso Fazello, and Stazione Centrale Pensilina Esterna in around 12h 33m. Alternatively, you can take a train from Isernia to Palermo Notarbartolo via Cassino and Palermo Centrale in around 12h 48m.

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