Rome2Rio

Hopkinton to Hyannis buses

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Trip Overview

The average bus between Hopkinton and Hyannis takes 4h 47m and the fastest bus takes 4h 36m. There is at least one bus per day from Hopkinton to Hyannis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 47m
Duration
105 mi
Distance
$36
Average price
Once daily
Frequency

Hopkinton to Hyannis bus times

Buses run once daily between Hopkinton and Hyannis. The earliest departure is at 9:58 AM in the morning, and the last departure from Hopkinton is at 10:38 AM which arrives into Hyannis at 3:15 PM. All services require a transfer at Framingham MBTA Station and take an average of 4h 47m. The schedules shown below are for the next available departures.

Departing Tuesday, November 10, 2026

  •  → 

    MetroWestGreyhound USAPlymouth & Brockton4h 36m • 2 changes

Departing Wednesday, November 11, 2026

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    MetroWestGreyhound USAPlymouth & Brockton4h 36m • 2 changes

Departing Thursday, November 12, 2026

  •  → 

    MetroWestGreyhound USAPlymouth & Brockton4h 36m • 2 changes

Departing Friday, November 13, 2026

  •  → 

    MetroWestGreyhound USAPlymouth & Brockton4h 36m • 2 changes

Departing Saturday, November 14, 2026

  •  → 

    MetroWestGreyhound USAPlymouth & Brockton5h 16m • 2 changes

Departing Sunday, November 15, 2026

  •  → 

    MetroWestGreyhound USAPlymouth & Brockton5h 16m • 2 changes

Departing Monday, November 16, 2026

  •  → 

    MetroWestGreyhound USAPlymouth & Brockton4h 36m • 2 changes

Frequently asked questions

Want to know about travelling from Hopkinton to Hyannis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Hopkinton to Hyannis.ExpandLaunch map view
  • Distance: 105.2 mi
  • Duration: 4h 47m

What companies run services between Hopkinton, MA, USA and Hyannis, MA, USA?

You can take a bus from Hopkinton Center to Hyannis Transportation Center via Framingham MBTA Station, Framingham, Boston, and Boston South Buses in around 5h 1m.

Operators