The average bus between Chicago and Hyannis takes 32h 25m and the fastest bus takes 26h 5m. The bus service runs several times per day from Chicago to Hyannis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Chicago and Hyannis. The earliest departure is at 12:25 PM in the afternoon, and the last departure from Chicago is at 7:15 PM which arrives into Hyannis at 9:35 AM. All services require a transfer at Newark Penn Station and take an average of 32h 25m. The schedules shown below are for the next available departures.
Arrives next day


29h 20m • 2 changes
Arrives +2 days


38h 20m • 2 changes
Arrives next day


27h 5m • 2 changes
Arrives +2 days


38h 20m • 2 changes
Arrives next day


27h 5m • 2 changes
Arrives +2 days


38h 20m • 2 changes
Want to know about travelling from Chicago to Hyannis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Chicago to Hyannis. However, there are services departing from Chicago station and arriving at Hyannis station via Newark Penn Station station. The journey, including transfers, takes approximately 32h 25m.
Chicago to Hyannis bus services, operated by Flixbus USA, depart from Chicago Bus Station.
Chicago to Hyannis bus services, operated by Flixbus USA, arrive at Hyannis Transportation Center station.
The distance between Chicago and Hyannis is 1,436.4 km. The road distance is 1,861 km.
You can take a bus from Chicago Bus Station to Hyannis Transportation Center via Newark Penn Station, Boston, and Boston South Station in around 25h 5m.