The average bus between Harlem and Chicago takes 19h 54m and the fastest bus takes 17h 58m. The bus service runs several times per day from Harlem to Chicago. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Harlem and Chicago. The earliest departure is at 9:38 AM in the morning, and the last departure from Harlem is at 8:27 PM which arrives into Chicago at 1:25 PM. All services require a transfer at 7 Av/W 31 St and take an average of 19h 54m. The schedules shown below are for the next available departures.
Arrives next day

20h 32m • 1 change
Arrives next day

16h 58m • 1 change
Arrives next day

20h 32m • 1 change
Arrives next day

16h 58m • 1 change
Arrives next day

20h 32m • 1 change
Arrives next day

16h 58m • 1 change
Want to know about travelling from Harlem to Chicago? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Harlem to Chicago. However, there are services departing from Harlem station and arriving at Chicago station via Chicago Bus Station station. The journey, including transfers, takes approximately 19h 54m.
Harlem to Chicago bus services, operated by MTA Bus Company, depart from New York Midtown station.
Harlem to Chicago bus services, operated by MTA Bus Company, arrive at Chicago Bus Station.
The distance between Harlem and Chicago is 1,147.1 km. The road distance is 1,436 km.
Flixbus USA operates a bus from New York Midtown to Chicago Bus Station twice daily. Tickets cost $110–200 and the journey takes 16h 55m.