The average bus between Harlem and Boston takes 5h 36m and the fastest bus takes 4h 57m. There is a bus service every few hours from Harlem to Boston. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Harlem and Boston. The earliest departure is at 12:38 AM at night, and the last departure from Harlem is at 11:04 PM which arrives into Boston at 4:40 AM. All services require a transfer at 7 Av/W 31 St and take an average of 5h 36m. The schedules shown below are for the next available departures.

5h 53m • 1 change

5h 37m • 1 change

5h 57m • 1 change

5h 39m • 1 change

5h 27m • 1 change

5h 37m • 1 change

5h 4m • 1 change

5h 50m • 1 change

5h 27m • 1 change

5h 37m • 1 change

5h 4m • 1 change

5h 35m • 1 change

5h 27m • 1 change

5h 37m • 1 change

5h 4m • 1 change

5h 50m • 1 change

5h 27m • 1 change

5h 37m • 1 change

5h 4m • 1 change

5h 50m • 1 change
Want to know about travelling from Harlem to Boston? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Harlem to Boston. However, there are services departing from Harlem station and arriving at Boston station via Boston. The journey, including transfers, takes approximately 5h 36m.
Harlem to Boston bus services, operated by MTA Bus Company, depart from New York Midtown station.
Harlem to Boston bus services, operated by MTA Bus Company, arrive at Boston station.
The distance between Harlem and Boston is 295.5 km. The road distance is 352 km.
Flixbus USA operates a bus from New York Midtown to Boston hourly. Tickets cost $27–50 and the journey takes 4h 20m.