Rome2Rio

Guelph to Chicago Loop buses

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Trip Overview

The average bus between Guelph and Chicago Loop takes 22h 18m and the fastest bus takes 19h 59m. The bus runs, on average, 3 times per week from Guelph to Chicago Loop. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

22h 18m
Duration
501 mi
Distance
$110
Average price
3 times a week
Frequency

Guelph to Chicago Loop bus times

Buses run 3 times a week between Guelph and Chicago Loop. The earliest departure is at 6:52 PM in the evening, and the last departure from Guelph is at 10:27 PM which arrives into Chicago Loop at 5:26 PM. All services require a transfer at Victoria / Bingemans Centre Dr. and take an average of 22h 18m. The schedules shown below are for the next available departures.

Departing Saturday, November 14, 2026

  •  → 

    Arrives next day

    GO TransitGO TransitFlixbus USAFlixbus USAChicago Transit (CTA)23h 26m • 4 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives next day

    GO TransitGO TransitFlixbus USAFlixbus USAChicago Transit (CTA)23h 30m • 4 changes

Departing Friday, November 20, 2026

  •  → 

    Arrives next day

    GO TransitGrand River TransitFlixbus USAFlixbus USAChicago Transit (CTA)19h 59m • 4 changes

Frequently asked questions

Want to know about travelling from Guelph to Chicago Loop? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Guelph to Chicago Loop.ExpandLaunch map view
  • Distance: 500.8 mi
  • Duration: 22h 18m

What companies run services between Guelph, ON, Canada and Chicago Loop, IL, USA?

You can take a bus from Guelph Central GO Bus to Washington & Lasalle via Victoria / Bingemans Centre Dr., Kitchener, Detroit Bus Station, Chicago Bus Station, and Jefferson & Harrison in around 14h 26m.

Operators