The average bus between Genoa and Sicily takes 22h 45m and the fastest bus takes 21h 23m. The bus service runs several times per day from Genoa to Sicily. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Genoa and Sicily. The earliest departure is at 11:15 AM in the morning, and the last departure from Genoa is at 6:20 PM which arrives into Sicily at 3:43 PM. All services require a transfer at Florence Villa Constanza Bus Station and take an average of 22h 45m. The schedules shown below are for the next available departures.
Arrives next day


24h 8m • 2 changes
Arrives next day


21h 23m • 2 changes
Arrives next day


24h 8m • 2 changes
Arrives next day


21h 23m • 2 changes
Arrives next day


24h 8m • 2 changes
Arrives next day


21h 23m • 2 changes
Arrives next day


24h 8m • 2 changes
Arrives next day


21h 23m • 2 changes
Want to know about travelling from Genoa to Sicily? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Genoa to Sicily. However, there are services departing from Genoa station and arriving at Sicily station via Florence Villa Constanza Bus Station station. The journey, including transfers, takes approximately 22h 45m.
Genoa to Sicily bus services, operated by FlixBus, depart from Genoa station.
Genoa to Sicily bus services, operated by FlixBus, arrive at Palermo station.
The distance between Genoa and Sicily is 874.7 km. The road distance is 1,507 km.
You can take a bus from Genoa to Piazza Boiardo via Florence Villa Constanza Bus Station, Palermo, and Stazione Centrale Pensilina Esterna in around 21h 9m.