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Gainesville to Florida Keys buses

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Trip Overview

The average bus between Gainesville and Florida Keys takes 25h 17m and the fastest bus takes 24h 10m. The bus runs, on average, 6 times per week from Gainesville to Florida Keys. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

25h 17m
Duration
499 mi
Distance
$100
Average price
6 times a week
Frequency

Gainesville to Florida Keys bus times

Buses run 6 times a week between Gainesville and Florida Keys. The earliest departure is at 5:20 AM in the morning, and the last departure from Gainesville is at 12:05 PM which arrives into Florida Keys at 12:15 PM. All services require a transfer at Miami Airport Station and take an average of 25h 17m. The schedules shown below are for the next available departures.

Departing Wednesday, November 4, 2026

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    Arrives next day

    Flixbus USAGreyhound USAKey West Transit30h 55m • 2 changes

Departing Thursday, November 5, 2026

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    Arrives next day

    Flixbus USAGreyhound USAKey West Transit24h 10m • 2 changes

Departing Friday, November 6, 2026

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    Arrives next day

    Flixbus USAGreyhound USAKey West Transit24h 10m • 2 changes

Departing Saturday, November 7, 2026

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    Arrives next day

    Flixbus USAGreyhound USAKey West Transit24h 10m • 2 changes

Departing Sunday, November 8, 2026

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    Arrives next day

    Flixbus USAGreyhound USAKey West Transit24h 10m • 2 changes

Departing Monday, November 9, 2026

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    Arrives next day

    Flixbus USAGreyhound USAKey West Transit24h 10m • 2 changes

Frequently asked questions

Want to know about travelling from Gainesville to Florida Keys? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Gainesville to Florida Keys.ExpandLaunch map view
  • Distance: 499.2 mi
  • Duration: 25h 17m

What companies run services between Gainesville, FL, USA and Florida Keys, FL, USA?

You can take a bus from Gainesville to Florida Keys via Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 14h 25m.

Operators