Rome2Rio

Denver to Santa Ana buses

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Trip Overview

The bus between Denver and Santa Ana takes 25h 25m. The bus runs, on average, 6 times per week from Denver to Santa Ana. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

25h 25m
Duration
1,028 mi
Distance
$214
Average price
6 times a week
Frequency

Denver to Santa Ana bus times

Buses run 6 times a week between Denver and Santa Ana. The service departs Denver at 11:05 AM in the morning, which arrives into Santa Ana at 11:30:00. All services require a transfer, and take on average 25h 25m. The schedules shown below are for the next available departures.

Departing Sunday, November 15, 2026

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    Arrives next day

    Greyhound USAGreyhound USA25h 25m • 1 change

Departing Monday, November 16, 2026

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    Arrives next day

    Greyhound USAGreyhound USA25h 25m • 1 change

Departing Tuesday, November 17, 2026

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    Arrives next day

    Greyhound USAGreyhound USA25h 25m • 1 change

Departing Wednesday, November 18, 2026

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    Arrives next day

    Greyhound USAGreyhound USA25h 25m • 1 change

Departing Thursday, November 19, 2026

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    Arrives next day

    Greyhound USAGreyhound USA25h 25m • 1 change

Departing Friday, November 20, 2026

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    Arrives next day

    Greyhound USAGreyhound USA25h 25m • 1 change

Frequently asked questions

Want to know about travelling from Denver to Santa Ana? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Denver to Santa Ana.ExpandLaunch map view
  • Distance: 1,028.3 mi
  • Duration: 25h 25m

What companies run services between Denver, CO, USA and Santa Ana, CA, USA?

You can take a bus from Denver Union Station to Santa Ana Bus Stop via Las Vegas Bus Terminal in around 21h 55m.

Operators