The average bus between Como and Mendrisio takes 53 min and the fastest bus takes 43 min. There is a bus service every few hours from Como to Mendrisio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Como and Mendrisio. The earliest departure is at 6:32 AM in the morning, and the last departure from Como is at 7:12 PM which arrives into Mendrisio at 8:04 PM. All services require a transfer, and take on average 53 min. The schedules shown below are for the next available departures.

52 min • 1 change

50 min • 1 change

1h 2m • 1 change

52 min • 1 change

1h 2m • 1 change

52 min • 1 change

1h 2m • 1 change

43 min • 1 change

1h 2m • 1 change

52 min • 1 change

1h 2m • 1 change

43 min • 1 change

1h 2m • 1 change

52 min • 1 change

1h 2m • 1 change

43 min • 1 change
Want to know about travelling from Como to Mendrisio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Como to Mendrisio. However, there are services departing from Como station and arriving at Mendrisio station via Chiasso - Stazione. The journey, including transfers, takes approximately 53 min.
Como to Mendrisio bus services, operated by ASF Autolinee S.r.l., depart from Como - San Rocchetto station.
Como to Mendrisio bus services, operated by ASF Autolinee S.r.l., arrive at Mendrisio, Autosilo station.
The distance between Como and Mendrisio is 10.2 km. The road distance is 16 km.
You can take a bus from Como - San Rocchetto to Mendrisio, Autosilo via Chiasso, Stazione in around 54 min.