Rome2Rio

Cincinnati to Des Moines buses

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Trip Overview

The average bus between Cincinnati and Des Moines takes 28h 8m and the fastest bus takes 25h 55m. The bus runs, on average, 6 times per week from Cincinnati to Des Moines. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

28h 8m
Duration
635 mi
Distance
$128
Average price
6 times a week
Frequency

Cincinnati to Des Moines bus times

Buses run 6 times a week between Cincinnati and Des Moines. The earliest departure is at 7:00 AM in the morning, and the last departure from Cincinnati is at 1:40 PM which arrives into Des Moines at 2:35 PM. All services require a transfer, and take on average 28h 8m. The schedules shown below are for the next available departures.

Departing Sunday, November 15, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USA25h 55m • 1 change

Departing Monday, November 16, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USA25h 55m • 1 change

Departing Wednesday, November 18, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USA32h 35m • 1 change

Departing Thursday, November 19, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USA25h 55m • 1 change

Departing Friday, November 20, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USA25h 55m • 1 change

Frequently asked questions

Want to know about travelling from Cincinnati to Des Moines? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Cincinnati to Des Moines.ExpandLaunch map view
  • Distance: 634.6 mi
  • Duration: 28h 8m

What companies run services between Cincinnati, OH, USA and Des Moines, IA, USA?

You can take a bus from Cincinnati to Des Moines via Chicago Bus Station in around 13h 30m.

Operators