The average bus between Cholula and Tlaxcala takes 1h 50m and the fastest bus takes 1h 5m. The bus service runs several times per day from Cholula to Tlaxcala. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Cholula and Tlaxcala. The earliest departure is at 12:00 AM at night, and the last departure from Cholula is at 9:55 PM which arrives into Tlaxcala at 11:10 PM. All services require a transfer at Puebla, Central de Autobuses and take an average of 1h 50m. The schedules shown below are for the next available departures.

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Want to know about travelling from Cholula to Tlaxcala? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Cholula to Tlaxcala. However, there are services departing from Cholula station and arriving at Tlaxcala station via Puebla, Central de Autobuses. The journey, including transfers, takes approximately 1h 50m.
Cholula to Tlaxcala bus services, operated by Flixbus USA, depart from Puebla station.
Cholula to Tlaxcala bus services, operated by Flixbus USA, arrive at Tlaxcala CATLA station.
The distance between Cholula and Tlaxcala is 30.3 km. The road distance is 42 km.
You can take a bus from Puebla to Tlaxcala CATLA via Puebla, Central de Autobuses and Puebla CAPU in around 1h 27m.