Rome2Rio

Cape Cod to San Diego buses

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Trip Overview

The average bus between Cape Cod and San Diego takes 3d 19h and the fastest bus takes 3d 18h. The bus runs, on average, 2 times per week from Cape Cod to San Diego. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

3d 19h
Duration
3,355 mi
Distance
Twice a week
Frequency

Cape Cod to San Diego bus times

Buses run twice a week between Cape Cod and San Diego. The earliest departure is at 11:46 AM in the morning, and the last departure from Cape Cod is at 1:46 PM which arrives into San Diego at 5:35 AM. All services require a transfer at Hyannis Transportation Center and take an average of 3d 19h. The schedules shown below are for the next available departures.

Departing Monday, November 16, 2026

  •  → 

    Arrives +4 days

    Cape Cod Regional Transit AuthorityPlymouth & BrocktonFlixbus USAGreyhound USAGreyhound USAAmtrak3d 18h • 5 changes

Departing Tuesday, November 17, 2026

  •  → 

    Arrives +4 days

    Cape Cod Regional Transit AuthorityPlymouth & BrocktonGreyhound USAGreyhound USAGreyhound USAAmtrak3d 20h • 5 changes

Frequently asked questions

Want to know about travelling from Cape Cod to San Diego? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Cape Cod to San Diego.ExpandLaunch map view
  • Distance: 3,355.3 mi
  • Duration: 3d 19h

What companies run services between Cape Cod, MA, USA and San Diego, CA, USA?

You can take a bus from Town Hall Lawton Bus Shelter to San Diego via Hyannis Transportation Center, Boston, South Station, Boston, Newark Penn Station, St Louis Bus Station, Los Angeles Union Station, and Los Angeles in around 3d 5h.

Operators