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Cape Cod to Florida buses

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Trip Overview

The average bus between Cape Cod and Florida takes 27h and the fastest bus takes 26h 19m. The bus runs, on average, 3 times per week from Cape Cod to Florida. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

27h
Duration
1,279 mi
Distance
$278
Average price
3 times a week
Frequency

Cape Cod to Florida bus times

Buses run 3 times a week between Cape Cod and Florida. The earliest departure is at 11:46 AM in the morning, and the last departure from Cape Cod is at 1:46 PM which arrives into Florida at 4:05 PM. All services require a transfer at Hyannis Transportation Center and take an average of 27h. The schedules shown below are for the next available departures.

Departing Monday, November 16, 2026

  •  → 

    Arrives next day

    Cape Cod Regional Transit AuthorityPlymouth & BrocktonFlixbus USAFlixbus USAJacksonville Transport26h 19m • 4 changes

Departing Tuesday, November 17, 2026

  •  → 

    Arrives next day

    Cape Cod Regional Transit AuthorityPlymouth & BrocktonGreyhound USAFlixbus USAJacksonville Transport28h 19m • 4 changes

Departing Friday, November 20, 2026

  •  → 

    Arrives next day

    Cape Cod Regional Transit AuthorityPlymouth & BrocktonFlixbus USAFlixbus USAJacksonville Transport26h 24m • 4 changes

Frequently asked questions

Want to know about travelling from Cape Cod to Florida? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Cape Cod to Florida.ExpandLaunch map view
  • Distance: 1,279.3 mi
  • Duration: 27h

What companies run services between Cape Cod, MA, USA and Florida, USA?

You can take a bus from Town Hall Lawton Bus Shelter to Newnan St + Ashley St via Hyannis Transportation Center, Boston, South Station, Boston, Newark Penn Station, Jacksonville, and JRTC Bay J in around 28h 15m.

Operators