There are 6 ways to get from Buffalo to Chicago Loop by plane, subway, train (Amtrak), bus (Greyhound), car, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Buffalo Niagara International Airport to Chicago Midway International Airport, subway
best- Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane BUF - MDW
- Take the subway from Midway to Washington/Wellssubway
4h 11m$114–757Bus
cheapest- Take the bus from Buffalo to Cleveland Bus Stationbus Greyhound US0170
- Take the bus from Cleveland Bus Station to Chicago Bus Stationbus Greyhound US0164
12h 44m$66–144Train (Amtrak)
- Take the train from Buffalo Depew Station to Chicago Union Stationtrain Lake Shore Limited
11h 50m$149–384Drive 532.4 mi
- Drive from Buffalo to Chicago Loopcar 532.4 mi
9h 2m$98–141Fly Buffalo Niagara International Airport to Chicago O'Hare International Airport
- Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane BUF - ORD
4h 28m$74–437Bus to Rochester, fly to Chicago Midway International Airport
- Take the bus from Buffalo to Rochester Bus Stopbus
- Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)plane ROC - MDW
5h 5m$129–701
Buffalo to Chicago Loop by train (Amtrak)
Questions & Answers
The cheapest way to get from Buffalo to Chicago Loop is to bus which costs $65 - $150 and takes 12h 44m.
The fastest way to get from Buffalo to Chicago Loop is to fly and subway which takes 4h 11m and costs $110 - $800.
No, there is no direct bus from Buffalo to Chicago Loop. However, there are services departing from Buffalo and arriving at Washington & Lasalle via Cleveland Bus Station and Jefferson & Harrison. The journey, including transfers, takes approximately 12h 44m.
No, there is no direct train from Buffalo to Chicago Loop station. However, there are services departing from Buffalo and arriving at Chicago Union Station via Buffalo Depew Station. The journey, including transfers, takes approximately 11h 50m.
The distance between Buffalo and Chicago Loop is 496 miles. The road distance is 535.5 miles.
The best way to get from Buffalo to Chicago Loop without a car is to train which takes 11h 50m and costs $140 - $390.
It takes approximately 4h 11m to get from Buffalo to Chicago Loop, including transfers.
Buffalo to Chicago Loop bus services, operated by Greyhound USA, depart from Buffalo station.
Buffalo to Chicago Loop train services, operated by Amtrak, depart from Buffalo Depew Station.
The best way to get from Buffalo to Chicago Loop is to train which takes 11h 50m and costs $140 - $390. Alternatively, you can bus, which costs $65 - $150 and takes 12h 44m, you could also fly, which costs $70 - $440 and takes 4h 28m.
What companies run services between Buffalo, NY, USA and Chicago Loop, IL, USA?
Amtrak operates a train from Buffalo Depew Station to Chicago Union Station twice daily. Tickets cost $140–310 and the journey takes 10h 33m. Alternatively, you can take a bus from Buffalo to Washington & Lasalle via Cleveland Bus Station, Chicago Bus Station, and Jefferson & Harrison in around 12h 44m.
- Website
- southwest.com
Flights from Buffalo Niagara International Airport to Chicago Midway International Airport
- Ave. Duration
- 1h 44m
- When
- Every day
- Estimated price
- $110–750
Flights from Rochester to Chicago Midway International Airport
- Ave. Duration
- 1h 57m
- When
- Every day
- Estimated price
- $100–650
Flights from Rochester to Chicago Midway International Airport via Baltimore
- Ave. Duration
- 4h 30m
- When
- Monday to Saturday
- Estimated price
- $140–750
- Website
- aa.com
Flights from Buffalo Niagara International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 7m
- When
- Every day
- Estimated price
- $70–430
Flights from Buffalo Niagara International Airport to Chicago O'Hare International Airport via Reagan Washington
- Ave. Duration
- 4h 46m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $100–550
- Website
- united.com
Flights from Buffalo Niagara International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 2m
- When
- Every day
- Estimated price
- $70–430
Flights from Buffalo Niagara International Airport to Chicago O'Hare International Airport via Washington Dulles
- Ave. Duration
- 4h 45m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $100–550
- Website
- delta.com
Flights from Buffalo Niagara International Airport to Chicago Midway International Airport via Detroit
- Ave. Duration
- 3h 38m
- When
- Every day
- Estimated price
- $110–750
Flights from Buffalo Niagara International Airport to Chicago O'Hare International Airport via Detroit
- Ave. Duration
- 3h 59m
- When
- Every day
- Estimated price
- $70–430
Flights from Rochester to Chicago Midway International Airport via Detroit
- Ave. Duration
- 3h 53m
- When
- Every day
- Estimated price
- $100–650
- Phone
- +1 888-968-7282
- Website
- transitchicago.com
Subway from Midway to Washington/Wells
- Ave. Duration
- 29 min
- Frequency
- Every 15 minutes
- Estimated price
- $2–5
- Website
- https://www.transitchicago.com
- Schedules at
- https://www.transitchicago.com/schedules/
- Adult
- $2–5
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Buffalo Depew Station to Chicago Union Station
- Ave. Duration
- 10h 33m
- Frequency
- Twice daily
- Estimated price
- $140–310
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Buffalo to Cleveland Bus Station
- Ave. Duration
- 3h 50m
- Frequency
- Once daily
- Estimated price
- $30–65
- Website
- https://www.greyhound.com/
Bus from Cleveland Bus Station to Chicago Bus Station
- Ave. Duration
- 7h 40m
- Frequency
- Twice daily
- Estimated price
- $60–120
- Website
- https://www.greyhound.com/
Bus from Buffalo to Rochester Bus Stop
- Ave. Duration
- 1h 25m
- Frequency
- 3 times a day
- Estimated price
- $12–24
- Website
- https://www.greyhound.com/
- Phone
- +1 888-378-3823
- info@baronsbus.com
- Website
- baronsbus.com
Bus from Cleveland Bus Station to Chicago Bus Station
- Ave. Duration
- 7h 35m
- Frequency
- Once daily
- Estimated price
- $30–80
- Website
- https://baronsbus.com
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Buffalo to Rochester Bus Stop
- Ave. Duration
- 1h 15m
- Frequency
- Every 3 hours
- Estimated price
- $9–16
- Schedules at
- flixbus.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide
More Questions & Answers
Buffalo to Chicago Loop bus services, operated by Greyhound USA, arrive at Cleveland Bus Station.
Chicago Loop is 1h behind Buffalo. It is currently 6:16 AM in Buffalo and 5:16 AM in Chicago Loop.
Buffalo to Chicago Loop train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Buffalo to Chicago Loop is 536 miles. It takes approximately 9h 2m to drive from Buffalo to Chicago Loop.
Book your Buffalo to Chicago Loop train tickets online with Omio.
There are 1295+ hotels available in Chicago Loop.