The average bus between Brussels and Melsele takes 2h 6m and the fastest bus takes 1h 39m. There is a bus service every few hours from Brussels to Melsele. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 2 hours between Brussels and Melsele. The earliest departure is at 4:15 AM at night, and the last departure from Brussels is at 9:20 PM which arrives into Melsele at 5:36 AM. All services require a transfer at Antwerp Rooseveltplaats and take an average of 2h 6m. The schedules shown below are for the next available departures.


2h 15m • 2 changes

1h 51m • 2 changes

1h 41m • 2 changes

1h 46m • 2 changes

2h 49m • 2 changes

1h 39m • 2 changes

1h 48m • 2 changes

2h 6m • 2 changes

3h 41m • 2 changes

2h 11m • 2 changes

2h 9m • 2 changes

2h 9m • 2 changes

1h 51m • 2 changes

1h 49m • 2 changes

2h • 2 changes

2h 1m • 2 changesWant to know about travelling from Brussels to Melsele? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Brussels to Melsele. However, there are services departing from Brussels station and arriving at Melsele station via Antwerp Rooseveltplaats. The journey, including transfers, takes approximately 2h 6m.
Brussels to Melsele bus services, operated by FlixBus, depart from Brussels-North train station.
Brussels to Melsele bus services, operated by FlixBus, arrive at Antwerpen Van Eedenplein station.
The distance between Brussels and Melsele is 41.5 km. The road distance is 65 km.
You can take a bus from Brussels-North train station to Melsele Spoorweglaan via Antwerp Rooseveltplaats, Antwerpen Opera, Antwerpen Van Eedenplein, and Antwerpen Van Eedenplein perron 3 in around 2h 3m.