The average bus between Brussels and Melsele takes 2h 13m and the fastest bus takes 1h 44m. There is a bus service every few hours from Brussels to Melsele. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Brussels and Melsele. The earliest departure is at 4:15 AM at night, and the last departure from Brussels is at 9:20 PM which arrives into Melsele at 5:36 AM. All services require a transfer at Antwerp Rooseveltplaats and take an average of 2h 13m. The schedules shown below are for the next available departures.


2h 6m • 2 changes


2h 26m • 2 changes


4h • 2 changes


2h • 2 changes


3h 41m • 2 changes


2h 11m • 2 changes


2h 9m • 2 changes


2h 39m • 2 changes


2h 6m • 2 changes


2h 6m • 2 changes


2h 16m • 2 changes


2h 1m • 2 changes


2h 6m • 2 changes


2h 1m • 2 changes


2h 16m • 2 changes


4h 1m • 2 changes
Want to know about travelling from Brussels to Melsele? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Brussels to Melsele. However, there are services departing from Brussels station and arriving at Melsele station via Antwerp Rooseveltplaats. The journey, including transfers, takes approximately 2h 13m.
Brussels to Melsele bus services, operated by FlixBus, depart from Brussels-North train station.
Brussels to Melsele bus services, operated by FlixBus, arrive at Antwerpen Van Eedenplein station.
The distance between Brussels and Melsele is 41.5 km. The road distance is 75 km.
You can take a bus from Brussels-North train station to Melsele Spoorweglaan via Antwerp Rooseveltplaats, Antwerpen Opera, Antwerpen Van Eedenplein, and Antwerpen Van Eedenplein perron 3 in around 2h 17m.