Rome2Rio

Boston to Lake City buses

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Trip Overview

The average bus between Boston and Lake City takes 25h 37m and the fastest bus takes 24h 5m. The bus runs, on average, 4 times per week from Boston to Lake City. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

25h 37m
Duration
1,259 mi
Distance
$257
Average price
4 times a week
Frequency

Boston to Lake City bus times

Buses run 4 times a week between Boston and Lake City. The earliest departure is at 1:15 PM in the afternoon, and the last departure from Boston is at 5:15 PM which arrives into Lake City at 5:20 PM. All services require a transfer at Newark Penn Station and take an average of 25h 37m. The schedules shown below are for the next available departures.

Departing Saturday, November 14, 2026

  •  → 

    Arrives next day

    Flixbus USAFlixbus USAGreyhound USA28h 5m • 2 changes

Departing Monday, November 16, 2026

  •  → 

    Arrives next day

    Flixbus USAFlixbus USAGreyhound USA24h 5m • 2 changes

Departing Tuesday, November 17, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAGreyhound USA26h 15m • 2 changes

Departing Friday, November 20, 2026

  •  → 

    Arrives next day

    Flixbus USAFlixbus USAGreyhound USA24h 5m • 2 changes

Frequently asked questions

Want to know about travelling from Boston to Lake City? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Boston to Lake City.ExpandLaunch map view
  • Distance: 1,259.1 mi
  • Duration: 25h 37m

What companies run services between Boston, MA, USA and Lake City, FL, USA?

You can take a bus from Boston to Lake City Bus Station via Newark Penn Station and Jacksonville in around 26h 10m.

Operators