The average bus between Boston and Chicago Loop takes 25h 48m and the fastest bus takes 21h 25m. The bus service runs several times per day from Boston to Chicago Loop. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Boston and Chicago Loop. The earliest departure is at 1:30 AM at night, and the last departure from Boston is at 5:15 PM which arrives into Chicago Loop at 1:42 PM. All services require a transfer at Newark Penn Station and take an average of 25h 48m. The schedules shown below are for the next available departures.
Arrives next day


24h 26m • 2 changes
Arrives next day


20h 25m • 2 changes
Arrives next day


28h 56m • 2 changes
Arrives next day


22h 35m • 2 changes
Want to know about travelling from Boston to Chicago Loop? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Boston to Chicago Loop. However, there are services departing from Boston station and arriving at Chicago Loop station via Newark Penn Station station. The journey, including transfers, takes approximately 25h 48m.
Boston to Chicago Loop bus services, operated by Flixbus USA, depart from Boston station.
Boston to Chicago Loop bus services, operated by Flixbus USA, arrive at Chicago Bus Station.
The distance between Boston and Chicago Loop is 1,365.8 km. The road distance is 1,752 km.
You can take a bus from Boston to Washington & Lasalle via Newark Penn Station, Chicago Bus Station, and Jefferson & Harrison in around 22h 24m.