The average train between Baltimore and Buffalo takes 13h 17m and the fastest train takes 11h 21m. The train service runs several times per day from Baltimore to Buffalo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Baltimore and Buffalo. The earliest departure is at 7:03 AM in the morning, and the last departure from Baltimore is at 10:51 PM which arrives into Buffalo at 3:32 PM. All services require a transfer, and take on average 13h 17m. The schedules shown below are for the next available departures.

11h 52m • 1 change

11h 44m • 1 change
Arrives next day

16h 41m • 1 change

11h 52m • 1 change

11h 44m • 1 change
Arrives next day

16h 41m • 1 change

11h 21m • 1 change

11h 23m • 1 change
Arrives next day

16h 41m • 1 change

11h 21m • 1 change

11h 23m • 1 change
Arrives next day

16h 41m • 1 change
Want to know about travelling from Baltimore to Buffalo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Baltimore to Buffalo. However, there are services departing from Baltimore station and arriving at Buffalo station via Ny Moynihan Train Hall At Penn Station station. The journey, including transfers, takes approximately 13h 17m.
Baltimore to Buffalo train services, operated by Amtrak Northeast Regional, depart from Baltimore Penn Station.
Baltimore to Buffalo train services, operated by Amtrak Northeast Regional, arrive at Buffalo station.
Book your Baltimore to Buffalo train tickets online with Amtrak Northeast Regional, Amtrak and Amtrak Acela.
The distance between Baltimore and Buffalo is 442.6 km. The road distance is 1,002 km.
You can take a train from Baltimore Penn Station to Buffalo via Ny Moynihan Train Hall At Penn Station in around 12h 29m.