There are 10 ways to get from Zephyrhills to Florida Keys by train, bus, shuttle, car, plane, bus (Greyhound), or bus (Flixbus, Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train, bus
best- Take the train from Lakeland to Delray Beach Amtrak
- Take the train from Delray Beach Station to Miami Airport Station
- Take the bus from Miami Airport Station to Big Pine Key
12h 11m$162–301Bus via Tampa
cheapest- Take the bus from Tampa Bus Station to Miami Airport StationFlixBus 2421 / ...
- Take the bus from Miami Airport Station to Big Pine KeyGreyhound US0720s
16h 36m$62–108Bus, shuttle
- Take the bus from Tampa Downtown to Miami AirportRedCoach
- Take a shuttle bus from Miami, FL - International Airport to Summerland Key - Mote Marine LabTo the Keys
14h 33m$162–272Drive 374.5 mi
- Drive from Zephyrhills to Florida Keys374.5 mi
7h 33m$69–99Bus to Tampa, fly to Key West International Airport, bus
- Take the bus from Zephyrhills Downtown Transfer Station to Wiregrass Park and Ride
- Fly from Tampa (TPA) to Key West International Airport (EYW)TPA - EYW
- Take the bus from Whitehead & Eaton to Sugarloaf Key - Lower - Opposite Sugarloaf Lodge
8h 15m$186–612Bus
- Take the bus from Del Carmen Mexican Store - Dade City, FL to Dolphin Mall - MiamiHouston
- Take the bus from Miami Airport Station to Big Pine KeyGreyhound US0720s
15h 19m$94–220Fly Tampa to Miami International Airport, shuttle
- Fly from Tampa (TPA) to Miami International Airport (MIA)TPA - MIA
- Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FL
10h 50m$262–568Fly Tampa to Fort Lauderdale–Hollywood International Airport, shuttle
- Fly from Tampa (TPA) to Fort Lauderdale–Hollywood International Airport (FLL)TPA - FLL
- Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FL
11h 20m$216–358Bus, shuttle to Orlando, fly to Key West International Airport
- Take the bus from Del Carmen Mexican Store - Dade City, FL to TA Travel Center - Wildwood, FL
- Take a shuttle bus from Brownwood Hotel & Spa to MCO Airport - Terminal A
- Fly from Orlando (MCO) to Key West International Airport (EYW)MCO - EYW
9h 10m$230–820Bus, shuttle, line 300 bus to Saint Petersburg–Clearwater International Airport, fly to Key West International Airport
- Take the bus from Zephyrhills Downtown Transfer Station to Wiregrass Park and Ride
- Take a shuttle bus from Gate Gas Station Wesley Chapel to Tampa International Airport - Red Terminal
- Take the bus from TPA RENTAL CAR FACILITY westbound to Psta 34Th St Layby - Platform - B
- Fly from Saint Petersburg–Clearwater International Airport (PIE) to Key West International Airport (EYW)PIE - EYW
- Take the bus from Whitehead & Eaton to Sugarloaf Key - Lower - Opposite Sugarloaf Lodge
10h 33m$128–438
Zephyrhills to Florida Keys by bus and foot
Questions & Answers
The cheapest way to get from Zephyrhills to Florida Keys is to bus via Tampa which costs $60 - $110 and takes 16h 36m.
The fastest way to get from Zephyrhills to Florida Keys is to drive which takes 7h 33m and costs $65 - $100.
No, there is no direct bus from Zephyrhills station to Florida Keys. However, there are services departing from Zephyrhills Downtown Transfer Station and arriving at Sugarloaf Key - Lower - Sugarloaf Lodge via Del Carmen Mexican Store - Dade City, FL, Dolphin Mall, Miami Airport Station and Big Pine Key - CVS / MM30. The journey, including transfers, takes approximately 15h 19m.
The distance between Zephyrhills and Florida Keys is 394 miles. The road distance is 376.6 miles.
The best way to get from Zephyrhills to Florida Keys without a car is to train and bus which takes 12h 11m and costs $160 - $310.
It takes approximately 12h 11m to get from Zephyrhills to Florida Keys, including transfers.
Zephyrhills to Florida Keys bus services, operated by Tornado Bus Company, depart from Del Carmen Mexican Store - Dade City, FL station.
Zephyrhills to Florida Keys bus services, operated by Tornado Bus Company, arrive at Dolphin Mall - Miami station.
Yes, the driving distance between Zephyrhills to Florida Keys is 377 miles. It takes approximately 7h 33m to drive from Zephyrhills to Florida Keys.
There are 120+ hotels available in Florida Keys.
What companies run services between Zephyrhills, FL, USA and Florida Keys, FL, USA?
You can take a bus from Zephyrhills Downtown Transfer Station to Florida Keys via 5th St & Martin Luther King Blvd, Del Carmen Mexican Store - Dade City, FL, Dolphin Mall, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 15h 19m.
Transport is disrupted due to the Russia-Ukraine war. Read more
- Website
- aa.com
Flights from Tampa to Key West International Airport via Miami International Airport
- Ave. Duration
- 3h 14m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $45–300
Flights from Tampa to Miami International Airport
- Ave. Duration
- 1h 7m
- When
- Every day
- Estimated price
- $30–230
- Website
- allegiantair.com
Flights from Saint Petersburg–Clearwater International Airport to Key West International Airport
- Ave. Duration
- 1h 3m
- When
- Monday, Wednesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $45–320
- Website
- southwest.com
Flights from Tampa to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 1h 8m
- When
- Monday, Tuesday, Wednesday, Friday, Saturday, and Sunday
- Estimated price
- $25–180
- Website
- flybreeze.com
Flights from Tampa to Key West International Airport
- Ave. Duration
- 1h 7m
- When
- Every day
- Estimated price
- $110–550
Flights from Orlando to Key West International Airport
- Ave. Duration
- 1h 15m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $110–600
- Website
- spirit.com
Flights from Tampa to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 1h 8m
- When
- Every day
- Estimated price
- $35–110
- Website
- jetblue.com
Flights from Tampa to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 1h 4m
- When
- Monday, Tuesday, Wednesday, Friday, Saturday, and Sunday
- Estimated price
- $25–180
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Lakeland to Delray Beach Amtrak
- Ave. Duration
- 3h 34m
- Frequency
- Once daily
- Estimated price
- $22–120
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 800-874-7245
- Website
- tri-rail.com
Train from Delray Beach Station to Miami Airport Station
- Ave. Duration
- 1h 24m
- Frequency
- Hourly
- Estimated price
- $5–9
- Website
- https://www.tri-rail.com
- Weekend | Holiday
- $5
- Weekday
- $6–9
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 35m
- Frequency
- Twice daily
- Estimated price
- $21–35
- Website
- https://www.greyhound.com/
Bus from Tampa Bus Station to Miami Airport Station
- Ave. Duration
- 8h
- Frequency
- Once daily
- Estimated price
- $35–60
- Website
- https://www.greyhound.com/
- Phone
- +1 877 733 0724
- Website
- redcoachusa.com
Bus from Tampa Downtown to Miami Airport
- Ave. Duration
- 4h 40m
- Frequency
- Once daily
- Estimated price
- $27–85
- Website
- https://www.redcoachusa.com
- Web
- $27–85
- Phone
- +1 (305) 289-9997
- groups@keysshuttle.com
- Website
- keysshuttle.com
Shuttle from Miami, FL - International Airport to Summerland Key - Mote Marine Lab
- Ave. Duration
- 3h 30m
- Frequency
- 4 times a day
- Estimated price
- $130–180
- Website
- https://www.keysshuttle.com
Shuttle from Miami, FL - International Airport to Big Pine Key, FL
- Ave. Duration
- 3h
- Frequency
- 4 times a day
- Estimated price
- $130–180
- Website
- https://www.keysshuttle.com
Shuttle from Fort Lauderdale, FL - International Airport to Big Pine Key, FL
- Ave. Duration
- 3h 30m
- Frequency
- 4 times a day
- Estimated price
- $150–200
- Website
- https://www.keysshuttle.com
- Phone
- +1 727-834-3322
- info@gopasco.com
- Website
- pascocountyfl.net
Bus from Zephyrhills Downtown Transfer Station to Wiregrass Park and Ride
- Ave. Duration
- 50 min
- Frequency
- Every 2 hours
- Estimated price
- $2
- Website
- https://www.pascocountyfl.net/services/gopasco/index.php
- Phone
- +1 (305) 600-1455
- Website
- cityofkeywest-fl.gov
Bus from Whitehead & Eaton to Sugarloaf Key - Lower - Opposite Sugarloaf Lodge
- Ave. Duration
- 36 min
- Frequency
- Every 3 hours
- Estimated price
- $2–4
- Schedules at
- https://www.cityofkeywest-fl.gov/595/Schedules-and-Route-Maps
- Phone
- +1 888 358 6762
- info@tornadobus.com
- Website
- tornadobus.com
Bus from Del Carmen Mexican Store - Dade City, FL to Dolphin Mall - Miami
- Ave. Duration
- 6h 20m
- Frequency
- Once daily
- Estimated price
- $70–180
- Schedules at
- tornadobus.com
- Adults 11-59
- $70–180
Bus from Del Carmen Mexican Store - Dade City, FL to TA Travel Center - Wildwood, FL
- Ave. Duration
- 40 min
- Frequency
- Once daily
- Estimated price
- $30–130
- Schedules at
- tornadobus.com
- Adults 11-59
- $30–130
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Tampa Bus Station to Miami Airport Station
- Ave. Duration
- 6h 20m
- Frequency
- Every 4 hours
- Estimated price
- $35–65
- Schedules at
- flixbus.com
- Phone
- +1 352 539 9664
- Website
- groometransportation.com
Shuttle from Brownwood Hotel & Spa to MCO Airport - Terminal A
- Ave. Duration
- 1h 10m
- Frequency
- Hourly
- Estimated price
- $35–50
- Website
- https://groometransportation.com/the-villages/?&sd_client_id=992f7c93-d719-43a2-9d9e-8c8cbbd08d74
- online discount
- $35–45
- call in
- $40–50
Shuttle from Gate Gas Station Wesley Chapel to Tampa International Airport - Red Terminal
- Ave. Duration
- 41 min
- Frequency
- Hourly
- Estimated price
- $26–40
- Website
- https://groometransportation.com/the-villages/?&sd_client_id=992f7c93-d719-43a2-9d9e-8c8cbbd08d74
- online discount
- $26–35
- call in
- $30–40
- Phone
- +1 727-540-1900
- ride@psta.net
- Website
- psta.net
Bus from TPA RENTAL CAR FACILITY westbound to Psta 34Th St Layby - Platform - B
- Ave. Duration
- 32 min
- Frequency
- Every 4 hours
- Estimated price
- $3
- Schedules at
- psta.net
- Adult
- $3
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide



















