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How to get fromWisconsin to Knoxvilleby plane, train, bus, bus (Greyhound, Flixbus), car, or bus (Flixbus, Greyhound)

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There are 11 ways to get from Wisconsin to Knoxville by plane, train, bus, bus (Greyhound, Flixbus), car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly General Mitchell International Airport to Mcghee Tyson Airport

    best
    1. Fly from General Mitchell International Airport (MKE) to Mcghee Tyson Airport (TYS)plane plane MKE - TYS
    5h 7m
    $237–1,072

  2. Drive 614.5 mi

    cheapest
    1. Drive from Milwaukee to Knoxvillecar car 614.5 mi
    10h 50m
    $113–162

  3. Train, bus

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    36h 14m
    $499–906

  4. Bus

    1. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to New York Midtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    38h 56m
    $335–518

  5. Fly Dane County Regional Airport-Truax Field to Mcghee Tyson Airport

    1. Fly from Dane County Regional Airport-Truax Field (MSN) to Mcghee Tyson Airport (TYS)plane plane MSN - TYS
    5h 41m
    $217–972

  6. Bus to Chicago O'Hare International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS)plane plane ORD - TYS
    4h 55m
    $193–711

  7. Train to Chicago Midway International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Kenosha to Chicago OTCtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Mcghee Tyson Airport (TYS)plane plane MDW - TYS
    5h 27m
    $204–933

  8. Bus to Minneapolis–Saint Paul International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Eau Claire Amtrak Bus Stop to Mall of America - IKEA - Bloomingtonbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Mcghee Tyson Airport (TYS)plane plane MSP - TYS
    5h 45m
    $254–960

  9. Fly General Mitchell International Airport to Nashville, drive

    1. Fly from General Mitchell International Airport (MKE) to Nashville (BNA)plane plane MKE - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    5h 44m
    $127–652

  10. Train, bus via Ossining

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    36h 49m
    $454–833

  11. Bus via Detroit

    1. Take the bus from Milwaukee Intermodal Station to Detroit Bus Stationbus bus
    2. Take the bus from Detroit Bus Station to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    39h 52m
    $333–536

General Mitchell International Airport (MKE) to Mcghee Tyson Airport (TYS) flights

Calendar100Weekly Planes
Duration4h 43mAverage Duration
Ticket$183Cheapest Price
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Questions & Answers

Map of how to get from Wisconsin to Knoxville.ExpandLaunch map view
  • Distance: 555.9 mi
  • Duration: 5h 7m

What companies run services between Wisconsin, USA and Knoxville, TN, USA?

Southwest Airlines, United Airlines, and two other airlines fly from General Mitchell International Airport (MKE) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from Milwaukee Intermodal Station to Knoxville via Chicago Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 38h 56m.

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