There are 9 ways to get from Wisconsin to Des Moines by plane, bus (Greyhound, Flixbus), car, bus, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Dane County Regional Airport-Truax Field
best- Fly from Dane County Regional Airport-Truax Field (MSN) to Des Moines (DSM)plane MSN - DSM
5h 22m$95–485Bus
cheapest- Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus Greyhound US0150
- Take the bus from Chicago Bus Station to Des Moinesbus Greyhound US0123S / ...
9h 5m$63–107Drive 354.8 mi
- Drive from Milwaukee to Des Moinescar 354.8 mi
6h 23m$65–94Bus to Chicago O'Hare International Airport, fly
- Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus
- Fly from Chicago O'Hare International Airport (ORD) to Des Moines (DSM)plane ORD - DSM
4h 25m$96–344Bus to Minneapolis–Saint Paul International Airport, fly
- Take the bus from Eau Claire Amtrak Bus Stop to Mall of America - IKEA - Bloomingtonbus
- Fly from Minneapolis–Saint Paul International Airport (MSP) to Des Moines (DSM)plane MSP - DSM
4h 38m$97–433Train to Chicago Midway International Airport, fly
- Take the train from Kenosha to Chicago OTCtrain
- Fly from Chicago Midway International Airport (MDW) to Des Moines (DSM)plane MDW - DSM
5h 12m$87–426Train, bus
- Take the train from Milwaukee to Chicago Union Stationtrain Hiawatha Service / ...
- Take the bus from Chicago Bus Station to Des Moinesbus Greyhound US0123S / ...
9h 8m$72–133Train, bus via Galesburg
- Take the train from Milwaukee to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain
- Take the bus from Galesburg to Des Moinesbus
11h$92–198Bus via Rochester
- Take the bus from Milwaukee to Rochesterbus
- Take the bus from Rochester to Owatonnabus
- Take the bus from Owatonna to Des Moinesbus
12h 44m$125–211
Wisconsin to Des Moines by bus
Comparing Your Travel Options
The cheapest way to get from Wisconsin to Des Moines is to bus which costs $60 - $110 and takes 9h 5m.
The fastest way to get from Wisconsin to Des Moines is to bus and fly which takes 4h 25m and costs $95 - $350.
No, there is no direct bus from Wisconsin station to Des Moines. However, there are services departing from Milwaukee Intermodal Station and arriving at Des Moines via Chicago Bus Station. The journey, including transfers, takes approximately 9h 5m.
The distance between Wisconsin and Des Moines is 261 miles. The road distance is 356.9 miles.
The best way to get from Wisconsin to Des Moines without a car is to bus which takes 9h 5m and costs $60 - $110.
It takes approximately 5h 22m to get from Wisconsin to Des Moines, including transfers.
Wisconsin to Des Moines bus services, operated by Greyhound USA, depart from Milwaukee Intermodal Station.
The best way to get from Wisconsin to Des Moines is to fly which takes 5h 22m and costs $95 - $490. Alternatively, you can bus, which costs $60 - $110 and takes 9h 5m.
Wisconsin to Des Moines bus services, operated by Greyhound USA, arrive at Chicago Bus Station.
Yes, the driving distance between Wisconsin to Des Moines is 357 miles. It takes approximately 6h 23m to drive from Wisconsin to Des Moines.
What companies run services between Wisconsin, USA and Des Moines, IA, USA?
United Airlines, American Airlines, and Delta fly from Dane County Regional Airport-Truax Field (MSN) to Des Moines (DSM) hourly. Alternatively, you can take a bus from Milwaukee Intermodal Station to Des Moines via Chicago Bus Station in around 9h 5m.
- Website
- aa.com
Flights from Dane County Regional Airport-Truax Field to Des Moines via Chicago O'Hare International Airport
- Ave. Duration
- 4h 23m
- When
- Every day
- Estimated price
- $75–460
Flights from Dane County Regional Airport-Truax Field to Des Moines via Dallas/Ft.Worth
- Ave. Duration
- 6h 20m
- When
- Every day
- Estimated price
- $160–750
Flights from Dane County Regional Airport-Truax Field to Des Moines via Reagan Washington
- Ave. Duration
- 7h 23m
- When
- Every day
- Estimated price
- $180–800
Flights from Dane County Regional Airport-Truax Field to Des Moines via Charlotte
- Ave. Duration
- 7h 31m
- When
- Thursday and Sunday
- Estimated price
- $170–800
Flights from Chicago O'Hare International Airport to Des Moines
- Ave. Duration
- 1h 31m
- When
- Every day
- Estimated price
- $40–280
- Phone
- +1 312-696-3872
- Website
- Metra
Train from Kenosha to Chicago OTC
- Ave. Duration
- 1h 42m
- Frequency
- Every 3 hours
- Estimated price
- $6–8
- Website
- Metra
- Adult
- $6–8
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- Greyhound
Bus from Milwaukee Intermodal Station to Chicago Bus Station
- Ave. Duration
- 1h 35m
- Frequency
- 4 times a day
- Estimated price
- $13–22
- Website
- Greyhound
Bus from Chicago Bus Station to Des Moines
- Ave. Duration
- 6h 30m
- Frequency
- 3 times a day
- Estimated price
- $50–85
- Website
- Greyhound
Bus from Chicago Bus Station to Des Moines
- Ave. Duration
- 6h 30m
- Frequency
- 3 times a day
- Estimated price
- $50–85
- Website
- Greyhound
Bus from Galesburg to Des Moines
- Ave. Duration
- 4h 55m
- Frequency
- Once daily
- Estimated price
- $30–55
- Website
- Greyhound
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Booking & Getting There
Book your Wisconsin to Des Moines bus tickets online with Omio and FlixBus.
There are 248+ hotels available in Des Moines.




