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How to get fromWayne State University to Chicagoby train (Amtrak), bus (Greyhound, Flixbus), car, bus, plane, bus (Flixbus) or train

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There are 9 ways to get from Wayne State University to Chicago by train (Amtrak), bus (Greyhound, Flixbus), car, bus, plane, bus (Flixbus), or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Detroit to Chicago Union Stationtrain train Wolverine
    5h 21m
    $45–130

  2. Bus

    cheapest
    1. Take the bus from Detroit Bus Station to Chicago Bus Stationbus bus Greyhound US0160
    7h 29m
    $32–96

  3. Drive 279.5 mi

    1. Drive from Wayne State University to Chicagocar car 279.5 mi
    4h 38m
    $51–74

  4. Line 16 bus to Detroit, fly to Chicago Midway International Airport

    1. Take the bus from Cass & Kirby to Grand River & Times Sqbus bus
    2. Fly from Detroit (DTW) to Chicago Midway International Airport (MDW)plane plane DTW - MDW
    4h 29m
    $50–328

  5. Bus via Chicago (Flixbus)

    1. Take the bus from Detroit Bus Station to Chicagobus bus FlixBus 2552
    9h 6m
    $38–96

  6. Drive to Capital Region International Airport, fly to Chicago O'Hare International Airport

    1. Drive from Wayne State University to Lansing-Airport-LANcar car
    2. Fly from Capital Region International Airport (LAN) to Chicago O'Hare International Airport (ORD)plane plane LAN - ORD
    3h 49m
    $69–369

  7. Line 16 bus to Detroit, fly to Chicago O'Hare International Airport

    1. Take the bus from Cass & Kirby to Grand River & Times Sqbus bus
    2. Fly from Detroit (DTW) to Chicago O'Hare International Airport (ORD)plane plane DTW - ORD
    4h 51m
    $116–348

  8. Fly Detroit to South Bend, train

    1. Fly from Detroit (DTW) to South Bend (SBN)plane plane DTW - SBN
    2. Take the train from South Bend Airport to Van Buren St.train train
    6h 46m
    $66–368

  9. Bus to Bishop International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Detroit Bus Station to Flintbus bus
    2. Fly from Bishop International Airport (FNT) to Chicago O'Hare International Airport (ORD)plane plane FNT - ORD
    6h 31m
    $52–272

Wayne State University to Chicago by foot and train (Amtrak)

Calendar21Weekly Services
Duration5h 21mAverage Duration
Ticket$45Cheapest Price
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Questions & Answers

What companies run services between Wayne State University, MI, USA and Chicago, IL, USA?

Amtrak operates a train from Detroit to Chicago Union Station 3 times a day. Tickets cost $45–130 and the journey takes 5h 6m. Alternatively, Greyhound USA operates a bus from Detroit Bus Station to Chicago Bus Station 3 times a day. Tickets cost $30–75 and the journey takes 6h 5m. Flixbus USA also services this route twice daily.

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