There are 6 ways to get from Washington University in St. Louis to Chicago by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to Chicago Midway  •  3 h 16 min

  1. Fly from St. Louis (STL) to Chicago Midway (MDW) STL - MDW

$124 - $306

Cheapest option

Bus Megabus  •  7 h 34 min

  1. Take the bus from St. Louis to Chicago, IL

$31 - $42

4 alternative options

Fly to Chicago O'Hare  •  3 h 45 min

  1. Fly from St. Louis (STL) to Chicago O'Hare (ORD) STL - ORD

$90 - $248

Bus Greyhound USA  •  7 h

  1. Take the bus from St Louis, Mo to Chicago, Il 1364 / ...

$40 - $90

Train  •  7 h

  1. Take the train from St. Louis Gateway Station to Chicago Union Station Lincoln Service / ...

$52 - $132

Drive  •  4 h 56 min

  1. Drive from Washington University in St. Louis to Chicago 305.1 miles

$29 - $45

Questions & Answers

No, there is no direct bus from Washington University in St. Louis to Chicago. However, there are services departing from Delmar @ 6144 Delmar Eb and arriving at Chicago, IL via St. Louis. The journey, including transfers, takes approximately 7 h 34 min.

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No, there is no direct train from Washington University in St. Louis station to Chicago station. However, there are services departing from SKINKER station and arriving at Chicago Union Station via St. Louis Gateway Station. The journey, including transfers, takes approximately 7 h.

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The distance between Washington University in St. Louis and Chicago is 265 miles. The road distance is 305.1 miles.

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The best way to get from Washington University in St. Louis to Chicago without a car is to bus which takes 7 h and costs .

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It takes approximately 3 h 16 min to get from Washington University in St. Louis to Chicago, including transfers.

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Washington University in St. Louis to Chicago bus services, operated by Megabus, depart from St. Louis station.

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Washington University in St. Louis to Chicago train services, operated by Amtrak, arrive at St. Louis Gateway Station.

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The best way to get from Washington University in St. Louis to Chicago is to fly which takes 3 h 16 min and costs . Alternatively, you can bus, which costs and takes 7 h, you could also train, which costs and takes 7 h.

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The quickest flight from St. Louis Airport to Chicago Midway Airport is the direct flight which takes 1 h.

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Washington University in St. Louis to Chicago bus services, operated by Megabus, arrive at Chicago, IL station.

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Map of how to get from Washington University in St. Louis to Chicago.
Launch map view
  • Distance: 265.4 miles
  • Duration: 3 h 16 min

What companies run services between Washington University in St. Louis, MO, USA and Chicago, IL, USA?

Southwest Airlines flies from Washington University in St. Louis to Chicago every 4 hours. Alternatively, Greyhound USA operates a bus from Washington University in St. Louis to Chicago every 30 minutes. Tickets cost $35 - $85 and the journey takes 6 h.

Airlines
Southwest Airlines
Website
southwest.com
Flights from St. Louis to Chicago Midway
Ave. Duration
1 h 2 min
When
Every day
Estimated price
$160 - $550
United Airlines
Website
united.com
Flights from St. Louis to Chicago O'Hare
Ave. Duration
1 h 22 min
When
Every day
Estimated price
$120 - $650
American Airlines
Website
aa.com
Flights from St. Louis to Chicago O'Hare
Ave. Duration
1 h 22 min
When
Every day
Estimated price
$120 - $550
Cape Air
Website
capeair.com
Flights from St. Louis to Chicago O'Hare via Decatur
Ave. Duration
3 h 3 min
When
Thursday and Friday
Estimated price
$130 - $380
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from St. Louis Gateway Station to Chicago Union Station
Ave. Duration
5 h 40 min
Frequency
Every 4 hours
Estimated price
$50 - $130
Website
amtrak.com
Coach Seat
$50 - $75
Flexi Coach Seat
$90 - $130
Business Coach Seat
$90 - $130
Room
$230 - $320
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from St Louis, Mo to Chicago, Il
Ave. Duration
6 h
Frequency
Every 30 minutes
Estimated price
$35 - $85
Website
greyhound.com
Economy
$35 - $55
Flexible
$65 - $85

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More Questions & Answers

Washington University in St. Louis to Chicago train services, operated by Amtrak, arrive at Chicago Union Station.

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Yes, the driving distance between Washington University in St. Louis to Chicago is 305 miles. It takes approximately 4 h 56 min to drive from Washington University in St. Louis to Chicago.

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Southwest Airlines offers flights from St. Louis Airport to Chicago Midway Airport.

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There are 580+ hotels available in Chicago. Prices start at $103 USD per night.

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Trips from Washington University in St. Louis