Greyhound Canada operates a bus from Vancouver to Lytton once daily. Tickets cost $21 - $55 and the journey takes 4 h 32 min. Alternatively, VIA Rail operates a train from Vancouver to Lytton 3 times a day. Tickets cost $30 - $100 and the journey takes 4 h 46 min.
From Vancouver, BC bus to Lytton, BC. 4 h 32 min $45. From Vancouver train to North Bend, walk to North Bend, BC, then bus to Lytton, BC. 6 h 34 min $88. From Vancouver drive to Lytton. 3 h 2 min $32.