There are 5 ways to get from UNION STATION station to Santa Fe Depot by plane, bus (Greyhound, Amtrak), train (Amtrak), car, train, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from Lambert–St. Louis International Airport (STL) to San Diego International Airport (SAN)STL - SAN
5h 54m$364–488Train, bus
cheapest- Take the train from St. Louis to Yuma Amtrak
- Take the bus from 3rd Street @ Gila Street to William Brook Ave @ B Street95
- Take the bus from San Luis Río Colorado to Mexicali
- Take the bus from Mexicali to Tijuana
2d 14h$206–707Bus
- Take the bus from St Louis Bus Station to Los Angeles Union StationGreyhound US1210
- Take the bus from Los Angeles to San DiegoAmtrak Thruway Connecting Service
43h 50mTrain (Amtrak)
- Take the train from St. Louis to Kansas City
- Take the train from Kansas City to Fullerton Amtrak Station
- Take the train from Fullerton Amtrak Station to San Diego
45h 1m$218–729Drive 1,797.9 mi
- Drive from UNION STATION station to Santa Fe Depot1,797.9 mi
29h 3m$329–474
Lambert–St. Louis International Airport (STL) to San Diego International Airport (SAN) flights
Questions & Answers
The cheapest way to get from UNION STATION station to Santa Fe Depot is to drive which costs $320 - $480 and takes 29h 3m.
The fastest way to get from UNION STATION station to Santa Fe Depot is to fly which takes 5h 54m and costs $360 - $490.
No, there is no direct bus from UNION STATION station station to Santa Fe Depot. However, there are services departing from St Louis Bus Station and arriving at San Diego via Los Angeles. The journey, including transfers, takes approximately 43h 50m.
No, there is no direct train from UNION STATION station to Santa Fe Depot. However, there are services departing from St. Louis and arriving at San Diego via Kansas City and Fullerton Amtrak Station. The journey, including transfers, takes approximately 45h 1m.
The distance between UNION STATION station and Santa Fe Depot is 1582 miles. The road distance is 1808.4 miles.
The best way to get from UNION STATION station to Santa Fe Depot without a car is to bus which takes 43h 50m and costs .
It takes approximately 5h 54m to get from UNION STATION station to Santa Fe Depot, including transfers.
UNION STATION station to Santa Fe Depot bus services, operated by Greyhound USA, depart from St Louis Bus Station.
UNION STATION station to Santa Fe Depot train services, operated by Amtrak, depart from St. Louis station.
The best way to get from UNION STATION station to Santa Fe Depot is to fly which takes 5h 54m and costs $360 - $490. Alternatively, you can bus, which costs and takes 43h 50m, you could also train, which costs $210 - $750 and takes 45h 1m.
What companies run services between UNION STATION station, MO, USA and Santa Fe Depot, San Diego County, CA, USA?
Southwest Airlines, United Airlines, and American Airlines fly from Lambert–St. Louis International Airport (STL) to San Diego International Airport (SAN) every 3 hours. Alternatively, you can take a vehicle from UNION STATION station to San Diego via St Louis Bus Station, Los Angeles Union Station, and Los Angeles in around 43h 50m.
Transport is disrupted due to the Russia-Ukraine war. Read more
- Website
- southwest.com
Flights from Lambert–St. Louis International Airport to San Diego International Airport
- Ave. Duration
- 3h 59m
- When
- Every day
- Estimated price
- $200–900
Flights from Lambert–St. Louis International Airport to San Diego International Airport via Phoenix
- Ave. Duration
- 5h 37m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $200–900
Flights from Lambert–St. Louis International Airport to San Diego International Airport via Denver
- Ave. Duration
- 5h 44m
- When
- Every day
- Estimated price
- $210–950
Flights from Lambert–St. Louis International Airport to San Diego International Airport via Las Vegas
- Ave. Duration
- 5h 50m
- When
- Monday and Saturday
- Estimated price
- $210–950
Flights from Lambert–St. Louis International Airport to San Diego International Airport via Dallas
- Ave. Duration
- 5h 55m
- When
- Monday and Friday
- Estimated price
- $220–950
- Website
- united.com
Flights from Lambert–St. Louis International Airport to San Diego International Airport via Denver
- Ave. Duration
- 5h 54m
- When
- Monday, Tuesday, Wednesday, Friday, Saturday, and Sunday
- Estimated price
- $210–950
- Website
- aa.com
Flights from Lambert–St. Louis International Airport to San Diego International Airport via Phoenix
- Ave. Duration
- 5h 55m
- When
- Monday, Tuesday, Wednesday, Friday, Saturday, and Sunday
- Estimated price
- $200–900
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from St. Louis to Kansas City
- Ave. Duration
- 5h 40m
- Frequency
- Twice daily
- Estimated price
- $35–220
- Website
- https://www.amtrak.com/home.html
Train from Kansas City to Fullerton Amtrak Station
- Ave. Duration
- 34h 52m
- Frequency
- Twice daily
- Estimated price
- $150–480
- Website
- https://www.amtrak.com/home.html
- Coach Seat - Advance Purchase
- $150–430
- Coach Seat short notice purchase
- $220–480
- Business - advance purchase
- $310–1,200
- Business Class
- $420–1,100
Train from Fullerton Amtrak Station to San Diego
- Ave. Duration
- 2h 23m
- Frequency
- Every 2 hours
- Estimated price
- $32–33
- Website
- https://www.amtrak.com/home.html
Train from St. Louis to Yuma Amtrak
- Ave. Duration
- 2d 7h
- Frequency
- 3 times a week
- Estimated price
- $180–600
- Website
- https://www.amtrak.com/home.html
- Coach Seat - Advance Purchase
- $180–550
- Coach Seat short notice purchase
- $280–600
- Business - advance purchase
- $380–1,500
- Business Class
- $500–1,300
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from St Louis Bus Station to Los Angeles Union Station
- Ave. Duration
- 39h 40m
- Frequency
- Twice daily
- Estimated price
- $110–360
- Website
- https://www.greyhound.com/
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from Los Angeles to San Diego
- Ave. Duration
- 3h
- Frequency
- Once daily
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 928-783-2235
- Website
- ycipta.org
Bus from 3rd Street @ Gila Street to William Brook Ave @ B Street
- Ave. Duration
- 1h 10m
- Frequency
- Hourly
- Estimated price
- $1–2
- Website
- https://www.ycipta.org/
- Youth 5-18 w/ Student ID, Seniors 65+, Disabled
- $1
- Adults 19-64
- $2
- Phone
- +52 55 5141 4300
- contacto@odm.com.mx
- Website
- odm.com.mx
Bus from San Luis Río Colorado to Mexicali
- Ave. Duration
- 1h 20m
- Frequency
- Every 30 minutes
- Estimated price
- $19–27
- Schedules at
- odm.com.mx
- Book at
- odm.com.mx
- Phone
- +52 55 4440 3187
- servicioalcliente@geb.mx
- Website
- autobuseselite.com.mx
Bus from San Luis Río Colorado to Mexicali
- Ave. Duration
- 1h 6m
- Frequency
- 4 times a day
- Estimated price
- $16–24
- Schedules at
- autobuseselite.com.mx
- Book at
- autobuseselite.com.mx
- Phone
- +52 644 410 2444
- atencionaclientes@tufesa.com.mx
- Website
- tufesa.com.mx
Bus from San Luis Río Colorado to Mexicali
- Ave. Duration
- 1h 30m
- Frequency
- Every 4 hours
- Estimated price
- $4–17
- Schedules at
- tufesa.com.mx
- Book at
- tufesa.com.mx
- Plus
- $4–17
- Titanium
- $5–17
- Phone
- +52 55 4440 3187
- servicioalcliente@geb.mx
- Website
- chihuahuenses.com.mx
Bus from San Luis Río Colorado to Mexicali
- Ave. Duration
- 1h 5m
- Frequency
- Twice daily
- Estimated price
- $12–19
- Schedules at
- chihuahuenses.com.mx
- Book at
- chihuahuenses.com.mx
- Phone
- +52 664 104 7400
- servicioalcliente@geb.mx
- Website
- abc.com.mx
Bus from San Luis Río Colorado to Mexicali
- Ave. Duration
- 1h 30m
- Frequency
- 5 times a day
- Estimated price
- $6–18
- Schedules at
- abc.com.mx
- Book at
- abc.com.mx
Bus from Mexicali to Tijuana
- Ave. Duration
- 2h 5m
- Frequency
- Every 3 hours
- Estimated price
- $16–35
- Schedules at
- abc.com.mx
- Book at
- abc.com.mx
- Phone
- +52 664 299 0487
- servicios@acnautobuses.com
- Website
- acnautobuses.com
Bus from San Luis Río Colorado to Mexicali
- Ave. Duration
- 2h
- Frequency
- Once daily
- Estimated price
- $45–75
- Schedules at
- acnautobuses.com
- Book at
- acnautobuses.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide
More Questions & Answers
UNION STATION station to Santa Fe Depot bus services, operated by Greyhound USA, arrive at Los Angeles Union Station.
Santa Fe Depot is 2h behind UNION STATION station. It is currently 11:30 AM in UNION STATION station and 9:30 AM in Santa Fe Depot.
UNION STATION station to Santa Fe Depot train services, operated by Amtrak, arrive at Kansas City station.
Yes, the driving distance between UNION STATION station to Santa Fe Depot is 1808 miles. It takes approximately 29h 3m to drive from UNION STATION station to Santa Fe Depot.
Book your UNION STATION station to Santa Fe Depot train tickets online with Omio.
There are 2117+ hotels available in Santa Fe Depot.





























