There are 8 ways to get from Tupelo to Indianapolis by car, plane, bus (Greyhound, Flixbus, Amtrak), bus, bus (Greyhound, Flixbus), or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Drive to Golden Triangle Regional Airport, fly
best- Drive from Tupelo to Golden Triangle Regional Airport (GTR)car
- Fly from Golden Triangle Regional Airport (GTR) to Indianapolis (IND)plane GTR - IND
7h 30m$112–617Drive 464.4 mi
cheapest- Drive from Tupelo to Indianapoliscar 464.4 mi
9h 33m$77–111Bus
- Take the bus from Tupelo to Memphis Bus Stationbus
- Take the bus from Memphis Bus Station to Nashville Bus Stationbus
- Take the bus from Nashville Bus Station to Indianapolis Union Stationbus
13h 39m$104–156Fly from Tupelo Regional Airport
- Fly from Tupelo Regional Airport (TUP) to Indianapolis (IND)plane TUP - IND
4h 44m$97–519Bus to Memphis, fly
- Take the bus from Tupelo to Memphis Bus Stationbus
- Fly from Memphis (MEM) to Indianapolis (IND)plane MEM - IND
8h 25m$132–694Bus via St. Louis
- Take the bus from Tupelo to Memphis Bus Stationbus
- Take the bus from Memphis Bus Station to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Indianapolis Union Stationbus
13h 54m$114–186Bus #2
- Take the bus from Tupelo to Memphis Bus Stationbus
- Take the bus from Memphis Bus Station to Champaign Intermodal Trans Ctrbus
- Take the bus from Champaign Intermodal Trans Ctr to Indianapolis Union Stationbus
14h 24m$125–196Bus #3
- Take the bus from Tupelo to Memphis Bus Stationbus Greyhound US0610
- Take the bus from Tornado Bus Co - West Memphis to Indianapolisbus Memphis
14h 48m$162–199
Golden Triangle Regional Airport (GTR) to Indianapolis (IND) flights
Comparing Your Travel Options
The cheapest way to get from Tupelo to Indianapolis is to drive which costs $75 - $120 and takes 9h 33m.
The fastest way to get from Tupelo to Indianapolis is to fly which takes 4h 44m and costs $95 - $550.
No, there is no direct bus from Tupelo to Indianapolis station. However, there are services departing from Tupelo and arriving at Indianapolis Union Station via Memphis Bus Station and Nashville Bus Station. The journey, including transfers, takes approximately 13h 39m.
The distance between Tupelo and Indianapolis is 530 miles. The road distance is 467.1 miles.
The best way to get from Tupelo to Indianapolis without a car is to bus which takes 13h 39m and costs $100 - $160.
It takes approximately 7h 30m to get from Tupelo to Indianapolis, including transfers.
Tupelo to Indianapolis bus services, operated by Greyhound USA, depart from Tupelo station.
The best way to get from Tupelo to Indianapolis is to bus which takes 13h 39m and costs $100 - $160. Alternatively, you can fly, which costs $95 - $550 and takes 4h 44m.
Tupelo to Indianapolis bus services, operated by Greyhound USA, arrive at Memphis Bus Station.
Indianapolis is 1h ahead of Tupelo. It is currently 8:09 AM in Tupelo and 9:09 AM in Indianapolis.
What companies run services between Tupelo, MS, USA and Indianapolis, IN, USA?
You can take a vehicle from Tupelo to Indianapolis Union Station via Tupelo, Memphis Bus Station, and Nashville Bus Station in around 13h 39m. Alternatively, Corporate Flight Management Inc, Southwest Airlines, and American Airlines fly from Tupelo Regional Airport (TUP) to Indianapolis (IND) twice daily.
- Website
- delta.com
Flights from Golden Triangle Regional Airport to Indianapolis via Atlanta
- Ave. Duration
- 6h 8m
- When
- Every day
- Estimated price
- $100–600
Flights from Memphis to Indianapolis via Atlanta
- Ave. Duration
- 4h 11m
- When
- Every day
- Estimated price
- $140–750
Flights from Memphis to Indianapolis via Detroit
- Ave. Duration
- 5h 15m
- When
- Every day
- Estimated price
- $140–800
- Website
- aa.com
Flights from Golden Triangle Regional Airport to Indianapolis via Dallas/Ft.Worth
- Ave. Duration
- 5h 15m
- When
- Every day
- Estimated price
- $150–750
Flights from Tupelo Regional Airport to Indianapolis via Dallas/Ft.Worth
- Ave. Duration
- 6h 10m
- When
- Every day
- Estimated price
- $150–750
Flights from Memphis to Indianapolis via Charlotte
- Ave. Duration
- 4h 47m
- When
- Every day
- Estimated price
- $160–800
Flights from Memphis to Indianapolis via Chicago O'Hare
- Ave. Duration
- 4h 32m
- When
- Every day
- Estimated price
- $130–750
- Website
- southwest.com
Flights from Tupelo Regional Airport to Indianapolis via Nashville
- Ave. Duration
- 4h 51m
- When
- Every day
- Estimated price
- $80–500
Flights from Memphis to Indianapolis via Nashville
- Ave. Duration
- 3h 25m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $100–650
Flights from Memphis to Indianapolis via Chicago Midway
- Ave. Duration
- 4h 55m
- When
- Monday to Thursday
- Estimated price
- $120–750
- Website
- united.com
Flights from Memphis to Indianapolis via Chicago O'Hare
- Ave. Duration
- 4h 57m
- When
- Every day
- Estimated price
- $130–750
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- Greyhound
Bus from Tupelo to Memphis Bus Station
- Ave. Duration
- 1h 50m
- Frequency
- Twice daily
- Estimated price
- $18–27
- Website
- Greyhound
Bus from Memphis Bus Station to Nashville Bus Station
- Ave. Duration
- 3h 50m
- Frequency
- 4 times a day
- Estimated price
- $35–60
- Website
- Greyhound
Bus from Nashville Bus Station to Indianapolis Union Station
- Ave. Duration
- 5h 55m
- Frequency
- 5 times a day
- Estimated price
- $50–80
- Website
- Greyhound
Bus from Tupelo to Memphis Bus Station
- Ave. Duration
- 1h 50m
- Frequency
- Twice daily
- Estimated price
- $18–27
- Website
- Greyhound
Bus from Tupelo to Memphis Bus Station
- Ave. Duration
- 1h 50m
- Frequency
- Twice daily
- Estimated price
- $18–27
- Website
- Greyhound
Bus from Memphis Bus Station to St Louis Bus Station
- Ave. Duration
- 5h 15m
- Frequency
- Once daily
- Estimated price
- $50–80
- Website
- Greyhound
Bus from St Louis Bus Station to Indianapolis Union Station
- Ave. Duration
- 4h 45m
- Frequency
- 3 times a day
- Estimated price
- $40–65
- Website
- Greyhound
Bus from Tupelo to Memphis Bus Station
- Ave. Duration
- 1h 50m
- Frequency
- Twice daily
- Estimated price
- $18–27
- Website
- Greyhound
Bus from Champaign Intermodal Trans Ctr to Indianapolis Union Station
- Ave. Duration
- 2h
- Frequency
- Once daily
- Estimated price
- $21–35
- Website
- Greyhound
Bus from Tupelo to Memphis Bus Station
- Ave. Duration
- 1h 50m
- Frequency
- Twice daily
- Estimated price
- $18–27
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Memphis Bus Station to Nashville Bus Station
- Ave. Duration
- 3h 30m
- Frequency
- 5 times a week
- Estimated price
- $30–50
- Schedules at
- Flixbus USA
Bus from Memphis Bus Station to St Louis Bus Station
- Ave. Duration
- 4h 45m
- Frequency
- 5 times a week
- Estimated price
- $45–70
- Schedules at
- Flixbus USA
Bus from Memphis Bus Station to Champaign Intermodal Trans Ctr
- Ave. Duration
- 8h 30m
- Frequency
- 5 times a week
- Estimated price
- $75–120
- Schedules at
- Flixbus USA
Rome2Rio's guide to Amtrak Thruway
Contact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from Nashville Bus Station to Indianapolis Union Station
- Ave. Duration
- 6h
- Frequency
- Twice daily
- Estimated price
- $45–55
- Website
- Amtrak
- Adult
- $45–55
- Phone
- +1 888 358 6762
- info@tornadobus.com
- Website
- Tornado Bus Company
Bus from Tornado Bus Co - West Memphis to Indianapolis
- Ave. Duration
- 9h 31m
- Frequency
- 3 times a week
- Estimated price
- $110–130
- Schedules at
- Tornado Bus Company
- Adult
- $110–130
Want to know more about travelling around United States
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Booking & Getting There
Yes, the driving distance between Tupelo to Indianapolis is 467 miles. It takes approximately 9h 33m to drive from Tupelo to Indianapolis.
Book your Tupelo to Indianapolis bus tickets online with Omio.
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