There are 4 ways to get from Trinidad to Cayo Guillermo by plane, car, train, taxi or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.
Recommended option
Fly Trinidad to Santa Clara, drive
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Fly from Trinidad (TDD) to Santa Clara (SNU)
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Drive from Santa Clara to Cayo Guillermo
3 alternative options
Fly Trinidad to Camaguey, train, taxi
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Fly from Trinidad (TDD) to Camaguey (CMW)
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Take the train from Camaguey to Ciego de Ávila
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Take a taxi from Morón to Cayo Guillermo
Bus to Santa Cruz, fly to Santa Clara, drive
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Take the bus from Trinidad to Santa Cruz de la Sierra - Terminal bimodal
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Fly from Santa Cruz (VVI) to Santa Clara (SNU)
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Drive from Santa Clara to Cayo Guillermo
Fly Trinidad to Varadero, train, taxi
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Fly from Trinidad (TDD) to Varadero (VRA)
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Take the train from Matanzas to Ciego de Ávila
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Take a taxi from Morón to Cayo Guillermo
Coronavirus (COVID-19) in Cuba
There is widespread community transmission globally.
Some travel restrictions are being lifted in Cuba. For the latest travel status, please check the official page for Cuba.
For travel planning advice, please refer to our Rome2rio Coronavirus information page .
Coronavirus (COVID-19) Travel Advice
Some border closures are in place for Cuba due to Coronavirus (COVID-19). Most travel to this country is restricted.
Some domestic travel restrictions began to ease in Cuba from July 3.
International flights leaving Bolivia are suspended as part of the response to Coronavirus (COVID-19). Restrictions may also be in place for other modes of transport.
Official Coronavirus (COVID-19) Information for BoliviaQuestions & Answers
The cheapest way to get from Trinidad to Cayo Guillermo is to fly and drive which costs $380 - $1,500 and takes 20h 3m.
The quickest way to get from Trinidad to Cayo Guillermo is to fly and drive which costs $380 - $1,500 and takes 20h 3m.
The distance between Trinidad and Cayo Guillermo is 4424 km.
It takes approximately 20h 3m to get from Trinidad to Cayo Guillermo, including transfers.
There is no direct flight from Trinidad Airport to Santa Clara Airport. The quickest flight takes 22h 5m and has two stopovers.
Cayo Guillermo is 1h behind Trinidad. It is currently 7:54 PM in Trinidad and 6:54 PM in Cayo Guillermo.
Amaszonas, EcoJet, American Airlines and two other airlines offer flights from Trinidad Airport to Santa Clara Airport.

- Distance: 4423.6 km
- Duration: 20h 3m
What companies run services between Trinidad, Bolivia and Cayo Guillermo, Cuba?
There is no direct connection from Trinidad to Cayo Guillermo. However, you can fly to Santa Clara then take the drive to Cayo Guillermo. Alternatively, you can fly to Camaguey, take the walk to Albaiza, take the bus to Amalia, take the bus to Los Coquitos, take the walk to Camaguey, take the train to Ciego de Ávila, take the walk to Ciego de Ávila, take the bus to Morón, then take the taxi to Cayo Guillermo.

- Website
- aa.com
Flights from Trinidad to Santa Clara via Cochabamba, Santa Cruz, Miami
- Ave. Duration
- 16h 40m
- When
- Every day
- Estimated price
- $490 - $1,600
Flights from Trinidad to Santa Clara via Santa Cruz, Miami
- Ave. Duration
- 16h 5m
- When
- Monday, Wednesday and Friday
- Estimated price
- $470 - $1,500
Flights from Trinidad to Santa Clara via La Paz, Santa Cruz, Miami
- Ave. Duration
- 22h 45m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
- Estimated price
- $500 - $1,600
Flights from Trinidad to Camaguey via Cochabamba, Santa Cruz, Miami
- Ave. Duration
- 17h 30m
- When
- Every day
- Estimated price
- $700 - $2,300
Flights from Trinidad to Camaguey via Santa Cruz, Miami
- Ave. Duration
- 16h 55m
- When
- Monday, Wednesday and Friday
- Estimated price
- $700 - $2,200
Flights from Trinidad to Camaguey via La Paz, Santa Cruz, Miami
- Ave. Duration
- 20h 47m
- When
- Monday to Saturday
- Estimated price
- $750 - $2,400
Flights from Santa Cruz to Santa Clara via Miami
- Ave. Duration
- 10h 52m
- When
- Every day
- Estimated price
- $550 - $1,700
Flights from Trinidad to Varadero via Cochabamba, Santa Cruz, Miami
- Ave. Duration
- 21h 55m
- When
- Every day
- Estimated price
- $480 - $1,500
Flights from Trinidad to Varadero via Santa Cruz, Miami
- Ave. Duration
- 21h 20m
- When
- Monday, Wednesday and Friday
- Estimated price
- $460 - $1,500
Flights from Trinidad to Varadero via La Paz, Santa Cruz, Miami
- Ave. Duration
- 25h 12m
- When
- Every day
- Estimated price
- $500 - $1,600
Flights from Trinidad to Varadero via Santa Cruz, Panama City, Miami
- Ave. Duration
- 21h 20m
- When
- Monday and Wednesday
- Estimated price
- $380 - $1,600

- Website
- copaair.com
Flights from Trinidad to Santa Clara via Santa Cruz, Panama City
- Ave. Duration
- 17h 45m
- When
- Monday and Wednesday
- Estimated price
- $360 - $1,500
Flights from Trinidad to Santa Clara via Cochabamba, Santa Cruz, Panama City
- Ave. Duration
- 18h 40m
- When
- Monday and Wednesday
- Estimated price
- $370 - $1,500
Flights from Trinidad to Santa Clara via La Paz, Santa Cruz, Panama City
- Ave. Duration
- 19h 15m
- When
- Monday and Wednesday
- Estimated price
- $380 - $1,600
Flights from Santa Cruz to Santa Clara via Panama City
- Ave. Duration
- 9h 47m
- When
- Tuesday and Thursday
- Estimated price
- $410 - $1,700

- Website
- en.wikipedia.org
Train from Camaguey to Ciego de Ávila
- Ave. Duration
- 2h 12m
- Frequency
- Hourly
- Estimated price
- $1
- Schedules at
- thebusschedule.com
- Old trains
- $1
- Second class
- $1
- First class
- $1
Train from Matanzas to Ciego de Ávila
- Ave. Duration
- 6h 51m
- Frequency
- 6 times a week
- Estimated price
- $1 - $2
- Schedules at
- thebusschedule.com
- Old trains
- $1
- Second class
- $1 - $2
- First class
- $1 - $2
Bus from Trinidad to Santa Cruz de la Sierra - Terminal bimodal
- Ave. Duration
- 10h
- Frequency
- Twice daily
- Estimated price
- $15

- Phone
- +591 76340023 Santa Cruz / 77666566 Yacuiba / 76340027 Trinidad / 76240024 Cochabamba
- Website
- facebook.com
Bus from Trinidad to Santa Cruz de la Sierra - Terminal Bimodal
- Ave. Duration
- 9h
- Frequency
- Once daily
- Estimated price
- $19
- Schedules at
- facebook.com

- Phone
- Cochabamba: +(591)44591818, +(591)72244625
- info@transcopacabanasa.com.bo
- Website
- transcopacabanasa.com
Bus from Trinidad to Santa Cruz
- Ave. Duration
- 10h
- Frequency
- Once daily
- Estimated price
- $9 - $20
- Schedules at
- transcopacabanasa.com
- Standard
- $9 - $12
- Cama
- $18 - $23
- Semi Cama
- $19 - $27

Bus from Trinidad to Santa Cruz
- Ave. Duration
- 10h 15m
- Frequency
- Once daily
- Estimated price
- $9 - $16
- Normal
- $9 - $11
- Semicama
- $13 - $16
- Cama
- $19 - $22

- Phone
- +591 6 0823904
- bolparbus@hotmail.com
- Website
- ticketsbolivia.com
Bus from Trinidad Bus Station to Santa Cruz Bus Station
- Ave. Duration
- 11h
- Frequency
- Once daily
- Estimated price
- $16 - $19
- Schedules at
- ticketsbolivia.com
- Ave. Duration
- 1h 22m
- Estimated price
- $65 - $80
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