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There are 8 ways to get from Toronto to Mayo Clinic by plane, bus, shuttle, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended

Fly Toronto to Rochester

  1. Fly from Toronto (YYZ) to Rochester (RST)

Cheapest

Train, bus

  1. Take the train from Toronto Union Station to Buffalo
  2. Take the train from Buffalo Depew Station to Chicago Union Station
  3. Take the train from Chicago Union Station to Winona Amtrak Station
  4. Take the bus from Winona Amtrak Station to Rochester, MN

Fly Toronto to Minneapolis, bus

  1. Fly from Toronto (YYZ) to Minneapolis (MSP)
  2. Take the bus from Minneapolis-St Paul Airport, MN to Rochester, MN

Shuttle to Buffalo, fly to Rochester

  1. Take a shuttle bus from Toronto Airport to Buffalo Airport
  2. Fly from Buffalo (BUF) to Rochester (RST)

Fly Toronto to La Crosse, bus

  1. Fly from Toronto (YYZ) to La Crosse (LSE)
  2. Take the bus from La Crosse Amtrak Station to Rochester, MN

Shuttle to Buffalo, fly to Minneapolis, bus

  1. Take a shuttle bus from Toronto Airport to Buffalo Airport
  2. Fly from Buffalo (BUF) to Minneapolis (MSP)
  3. Take the bus from Minneapolis-St Paul Airport, MN to Rochester, MN

Bus to Rochester, fly to Minneapolis, bus

  1. Take the bus from Toronto, ON to Rochester, NY
  2. Fly from Rochester (ROC) to Minneapolis (MSP)
  3. Take the bus from Minneapolis-St Paul Airport, MN to Rochester, MN

Drive

  1. Drive from Toronto to Mayo Clinic

Toronto to Mayo Clinic by train, bus and walk

The journey time between Toronto and Mayo Clinic is around 2 days 7h and covers a distance of around 1006 miles. This includes an average layover time of around 33h 55m. The fastest journey normally takes 2 days 7h. Operated by VIA Rail, Amtrak and Amtrak Thruway, the Toronto to Mayo Clinic service departs from Toronto Union Station and arrives in Mayo Clinic. Typically two services run weekly, although weekend and holiday schedules can vary so check in advance.

Explore all travel options

Average journey times

Time on transportation:
21h 30m
Layover time:
33h 55m
Total time:
2 days 7h

Route information

Fastest journey time:
2 days 7h
Journey distance:
1006 miles
Services per week:
2
Cheapest price:
$159
Carbon emissions:
90 kg CO2

First and last service

First service departs at:
08:20
Last service departs at:
08:20

The schedules shown below are for the next available departures.

Toronto to Mayo Clinic train, bus and walk schedules

Canada → United States
Partially open

Travel safe during COVID-19

International entry into United States from Canada

  • Entry is partially open for citizens and permanent residents of Canada
Show more details
Allowed for: All visitors arriving by air. Canada and Mexico land borders are closed to non-essential travel

Restricted for: Foreign nationals that have visited EU Schengen Area, Brazil, China, India, Iran, Ireland, South Africa and United Kingdom in the past 14 days. Canada and Mexico land borders are closed to non-essential travel

Show less

Conditions of entry into United States from Canada

  • Negative COVID-19 test issued at most 3 days prior to boarding for air passengers 2 years of age or older
  • Unvaccinated travellers are recommended to quarantine for a minimum of 7 days; take a COVID-19 test 3 days after arriving. If test is positive arrivals need to self-isolate until fully recovered
  • Vaccinated travellers are recommended to get tested with a viral test 3-5 days after travel; self-monitor for COVID-19 symptoms; isolate and get tested if symptoms develop
This applies to arrivals from all countries, with no exceptions

Rules to follow in United States

2m

Recommended

Recommended

Considerations leaving from Canada

The official advice is to delay international travel until fully vaccinated

Frequently Asked Questions


Yes, but conditions apply when entering United States from Canada.

Explore options for future travel

Domestic travel is not restricted, but some conditions may apply

  • Face masks are recommended
  • There is a social distancing requirement of 2 metres
  • Domestic border crossings may be subject to approval, testing and quarantine

Explore travel options

The national COVID-19 helpline number in Mayo Clinic is 800-232-4636.

Wearing a face mask on public transport in Mayo Clinic is recommended.

The social distance requirement in Mayo Clinic is 2 metres.

Make yourself known to an official member of staff and/or call the national coronavirus helpline number on 800-232-4636.

No, but conditions apply when returning to Canada from United States.

See options for return travel.

Last updated: 14 Sep 2021
Exceptions may apply, for full details: Centers for Disease control and prevention (CDC).

We're working around the clock to bring you the latest COVID-19 travel updates.
This information is compiled from official sources. To the best of our knowledge, it is correct as of the last update.
Visit Rome2rio travel advice for general help.

Questions & Answers

The cheapest way to get from Toronto to Mayo Clinic is to drive which costs $140 - $220 and takes 14h 27m.

More details

The quickest way to get from Toronto to Mayo Clinic is to fly and bus which costs $290 - $950 and takes 7h 4m.

More details

The distance between Toronto and Mayo Clinic is 656 miles. The road distance is 871.7 miles.

Get driving directions

The best way to get from Toronto to Mayo Clinic without a car is to train and bus which takes 24h 33m and costs $200 - $340.

More details

It takes approximately 8h 11m to get from Toronto to Mayo Clinic, including transfers.

More details

There is no direct flight from Toronto Airport to Rochester Airport. The quickest flight takes 4h 34m and has one stopover.

Search flights

Yes, the driving distance between Toronto to Mayo Clinic is 872 miles. It takes approximately 14h 27m to drive from Toronto to Mayo Clinic.

Get driving directions

Air Canada, United Airlines, American Airlines and Delta offer flights from Toronto Airport to Rochester Airport.

Search flights

There are 56+ hotels available in Mayo Clinic. Prices start at $100 USD per night.

More details

The best way to get from Toronto to Toronto Airport is to train which takes 25 min and costs $2 - $13.

More details

Map of how to get from Toronto to Mayo Clinic.
Launch map view
  • Distance: 655.6 miles
  • Duration: 8h 11m

What companies run services between Toronto, ON, Canada and Mayo Clinic, MN, USA?

American Airlines, Delta and three other airlines fly from Toronto to Mayo Clinic hourly.

Airlines
Delta
Website
delta.com
Flights from Toronto to Rochester via Minneapolis
Ave. Duration
4h 39m
When
Tuesday, Wednesday, Thursday, Friday, Saturday and Sunday
Estimated price
$440 - $600
Flights from Toronto to Rochester via Atlanta
Ave. Duration
9h 55m
When
Every day
Estimated price
$500 - $750
Flights from Toronto to Rochester via Detroit, Minneapolis
Ave. Duration
7h 57m
When
Every day
Estimated price
$450 - $600
Flights from Toronto to Rochester via New York La Guardia, Minneapolis
Ave. Duration
8h 12m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$490 - $700
Flights from Toronto to Minneapolis
Ave. Duration
2h 36m
When
Tuesday, Wednesday, Thursday, Friday, Saturday and Sunday
Estimated price
$300 - $370
Flights from Toronto to Minneapolis via Detroit
Ave. Duration
4h 31m
When
Every day
Estimated price
$300 - $380
Flights from Buffalo to Rochester via Minneapolis
Ave. Duration
3h 59m
When
Every day
Estimated price
$490 - $650
Flights from Buffalo to Rochester via Detroit, Minneapolis
Ave. Duration
8h 3m
When
Every day
Estimated price
$490 - $650
Flights from Buffalo to Rochester via Atlanta, Minneapolis
Ave. Duration
7h 22m
When
Every day
Estimated price
$550 - $850
Flights from Buffalo to Rochester via New York JFK, Minneapolis
Ave. Duration
8h 22m
When
Every day
Estimated price
$500 - $750
Flights from Toronto to La Crosse via Minneapolis
Ave. Duration
4h 23m
When
Tuesday, Wednesday, Thursday, Friday, Saturday and Sunday
Estimated price
$650 - $850
Flights from Toronto to La Crosse via Detroit
Ave. Duration
7h 44m
When
Every day
Estimated price
$600 - $800
Flights from Toronto to La Crosse via Detroit, Minneapolis
Ave. Duration
7h 13m
When
Every day
Estimated price
$650 - $850
Flights from Toronto to La Crosse via New York La Guardia, Detroit
Ave. Duration
7h 24m
When
Monday to Saturday
Estimated price
$650 - $950
Flights from Toronto to La Crosse via New York La Guardia, Minneapolis
Ave. Duration
7h 57m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$700 - $1,100
Flights from Buffalo to Minneapolis
Ave. Duration
2h 15m
When
Every day
Estimated price
$330 - $410
Flights from Buffalo to Minneapolis via Detroit
Ave. Duration
4h 6m
When
Every day
Estimated price
$330 - $420
Flights from Rochester to Minneapolis
Ave. Duration
2h 28m
When
Every day
Estimated price
$320 - $400
Flights from Rochester to Minneapolis via Detroit
Ave. Duration
4h 51m
When
Every day
Estimated price
$320 - $410
Flights from Rochester to Minneapolis via New York La Guardia
Ave. Duration
5h 6m
When
Monday to Saturday
Estimated price
$340 - $470
Flights from Rochester to Minneapolis via New York JFK
Ave. Duration
5h 16m
When
Every day
Estimated price
$340 - $470
American Airlines
Website
aa.com
Flights from Toronto to Rochester via Chicago O'Hare
Ave. Duration
4h 34m
When
Every day
Estimated price
$240 - $950
Flights from Toronto to Rochester via Reagan Washington, Chicago O'Hare
Ave. Duration
7h 36m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$270 - $1,100
Flights from Toronto to Minneapolis via Chicago O'Hare
Ave. Duration
4h 50m
When
Monday, Wednesday, Thursday, Friday, Saturday and Sunday
Estimated price
$370 - $1,000
Flights from Buffalo to Rochester via Chicago O'Hare
Ave. Duration
4h 40m
When
Every day
Estimated price
$240 - $800
Flights from Buffalo to Rochester via Charlotte, Chicago O'Hare
Ave. Duration
7h 41m
When
Every day
Estimated price
$260 - $900
Flights from Buffalo to Rochester via Philadelphia, Chicago O'Hare
Ave. Duration
8h 24m
When
Every day
Estimated price
$260 - $850
Flights from Buffalo to Rochester via Reagan Washington, Chicago O'Hare
Ave. Duration
8h 34m
When
Saturday
Estimated price
$250 - $850
Flights from Toronto to La Crosse via Chicago O'Hare
Ave. Duration
5h 55m
When
Monday, Wednesday, Thursday, Friday and Sunday
Estimated price
$340 - $1,400
Flights from Toronto to La Crosse via Charlotte, Chicago O'Hare
Ave. Duration
8h 10m
When
Monday, Wednesday, Thursday, Friday and Sunday
Estimated price
$410 - $1,600
Flights from Toronto to La Crosse via Reagan Washington, Chicago O'Hare
Ave. Duration
8h 57m
When
Monday, Wednesday, Thursday, Friday and Sunday
Estimated price
$390 - $1,500
Flights from Buffalo to Minneapolis via Chicago O'Hare
Ave. Duration
4h 27m
When
Every day
Estimated price
$200 - $500
Flights from Rochester to Minneapolis via Chicago O'Hare
Ave. Duration
4h 43m
When
Every day
Estimated price
$160 - $550
Flights from Rochester to Minneapolis via New York JFK
Ave. Duration
5h 19m
When
Monday, Thursday, Friday and Sunday
Estimated price
$140 - $550
United Airlines
Website
united.com
Flights from Toronto to Rochester via Denver
Ave. Duration
8h 20m
When
Every day
Estimated price
$370 - $1,600
Flights from Toronto to Minneapolis
Ave. Duration
2h 11m
When
Every day
Estimated price
$160 - $1,000
Flights from Toronto to Minneapolis via Chicago O'Hare
Ave. Duration
4h 38m
When
Every day
Estimated price
$250 - $1,400
Flights from Toronto to Minneapolis via Washington Dulles
Ave. Duration
5h 17m
When
Every day
Estimated price
$250 - $1,400
Flights from Buffalo to Minneapolis via Chicago O'Hare
Ave. Duration
4h 27m
When
Every day
Estimated price
$280 - $700
Flights from Rochester to Minneapolis via Chicago O'Hare
Ave. Duration
4h 40m
When
Every day
Estimated price
$160 - $600
Flights from Rochester to Minneapolis via Washington Dulles
Ave. Duration
5h 17m
When
Every day
Estimated price
$170 - $650
Air Canada
Website
aircanada.com
Flights from Toronto to Minneapolis
Ave. Duration
2h 11m
When
Every day
Estimated price
$160 - $1,000
Flights from Buffalo to Minneapolis via Chicago O'Hare
Ave. Duration
4h 27m
When
Every day
Estimated price
$280 - $700
Flights from Rochester to Minneapolis via Chicago O'Hare
Ave. Duration
4h 40m
When
Every day
Estimated price
$160 - $600
Southwest Airlines
Website
southwest.com
Flights from Buffalo to Minneapolis via Chicago Midway
Ave. Duration
4h 32m
When
Monday, Thursday, Friday, Saturday and Sunday
Estimated price
$140 - $460
JetBlue Airways
Website
jetblue.com
Flights from Rochester to Minneapolis via New York JFK
Ave. Duration
5h 19m
When
Monday, Thursday, Friday and Sunday
Estimated price
$140 - $550
Train operators
VIA Rail
Phone
+1 1 888 842-7245
Website
viarail.ca
Train from Toronto Union Station to Buffalo
Ave. Duration
4h 39m
Frequency
Once daily
Estimated price
$45 - $85
Website
VIA Rail
Escape
$25 - $40
Business
$70 - $85
Economy
$46 - $49
EconomyPlus
$60 - $85
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Buffalo Depew Station to Chicago Union Station
Ave. Duration
10h 30m
Frequency
4 times a day
Estimated price
$60 - $90
Schedules at
amtrak.com
Coach Seat
$60 - $90
Premium
$250 - $350
Flexi Coach Seat
$120 - $180
Business Seat
$120 - $180
Train from Chicago Union Station to Winona Amtrak Station
Ave. Duration
5h 26m
Frequency
3 times a day
Estimated price
$45 - $65
Schedules at
amtrak.com
Coach Seat
$45 - $65
Premium
$220 - $310
Flexi Coach Seat
$80 - $120
Business Seat
$80 - $120
Bus operators
Jefferson Lines
Phone
800-451-5333
Email
info@jeffersonlines.com
Website
jeffersonlines.com
Bus from Minneapolis-St Paul Airport, MN to Rochester, MN
Ave. Duration
1h 20m
Frequency
Once daily
Estimated price
$19 - $30
Book at
jeffersonlines.com
Niagara Airbus
Amtrak Thruway

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak Thruway
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Bus from La Crosse Amtrak Station to Rochester, MN
Ave. Duration
1h 40m
Frequency
3 times a week
Estimated price
$9 - $27
Schedules at
amtrak.com
Child 2-12
$9 - $14
Adult
$18 - $27
Bus from Winona Amtrak Station to Rochester, MN
Ave. Duration
55 min
Frequency
3 times a week
Estimated price
$7 - $21
Schedules at
amtrak.com
Child 2-12
$7 - $11
Adult
$15 - $21
OurBus
Phone
+1 844-800-6828
Website
ourbus.com
Bus from Toronto, ON to Rochester, NY
Ave. Duration
4h 35m
Frequency
5 times a week
Estimated price
$26 - $35
Book at
ourbus.com

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