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How to get fromTonawanda to Chicagoby bus, plane, train (Amtrak), bus (Greyhound) or car

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There are 6 ways to get from Tonawanda to Chicago by bus, plane, train (Amtrak), bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 25 bus to Buffalo Niagara International Airport, fly to Chicago Midway International Airport

    best
    1. Take the bus from Niagara Street & Main Street to South Division Street & Ellicott Loopbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane plane BUF - MDW
    5h 21m
    $129–835

  2. Bus

    cheapest
    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus Greyhound US0170
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    14h 15m
    $62–142

  3. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    10h 52m
    $157–326

  4. Drive 532.1 mi

    1. Drive from Tonawanda to Chicagocar car 532.1 mi
    9h 1m
    $98–141

  5. Line 25 bus to Buffalo Niagara International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Niagara Street & Main Street to South Division Street & Ellicott Loopbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane plane BUF - ORD
    5h 48m
    $79–485

  6. Bus to Rochester, fly to Chicago Midway International Airport

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)plane plane ROC - MDW
    6h 46m
    $130–702

Tonawanda to Chicago by bus

Calendar7Weekly Buses
Duration14h 15mAverage Duration
Ticket$62Cheapest Price
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Questions & Answers

What companies run services between Tonawanda, NY, USA and Chicago, IL, USA?

Amtrak operates a train from Buffalo Depew Station to Chicago Union Station twice daily. Tickets cost $110–270 and the journey takes 10h 33m. Alternatively, you can take a bus from Niagara Street & Main Street to Chicago Bus Station via South Division Street & Ellicott Loop, Buffalo, and Cleveland Bus Station in around 14h 15m.

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