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How to get fromTonawanda to Chicagoby bus, plane, train (Amtrak), bus (Greyhound), or car

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There are 6 ways to get from Tonawanda to Chicago by bus, plane, train (Amtrak), bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 25 bus to Buffalo Niagara International Airport, fly to Chicago Midway International Airport

    best
    1. Take the bus from Niagara Street & Main Street to South Division Street & Ellicott Loopbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane plane BUF - MDW
    5h 11m
    $89–515

  2. Line 25 bus to Buffalo Niagara International Airport, fly to Chicago O'Hare International Airport

    cheapest
    1. Take the bus from Niagara Street & Main Street to South Division Street & Ellicott Loopbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane plane BUF - ORD
    5h 34m
    $74–425

  3. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    10h 52m
    $217–396

  4. Bus (Greyhound)

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus Greyhound US0171 / ...
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    13h 25m
    $82–162

  5. Drive 532 mi

    1. Drive from Tonawanda to Chicagocar car 532 mi
    9h 2m
    $98–141

  6. Bus to Rochester, fly to Chicago Midway International Airport

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)plane plane ROC - MDW
    6h 46m
    $108–482

Tonawanda to Chicago by bus (Greyhound)

Calendar14Weekly Buses
Duration13h 25mAverage Duration
Ticket$82Cheapest Price
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Questions & Answers

Map of how to get from Tonawanda to Chicago.ExpandLaunch map view
  • Distance: 500.7 mi
  • Duration: 5h 11m

What companies run services between Tonawanda, NY, USA and Chicago, IL, USA?

Amtrak operates a train from Buffalo Depew Station to Chicago Union Station twice daily. Tickets cost $170–340 and the journey takes 10h 33m. Alternatively, you can take a bus from Niagara Street & Main Street to Chicago Bus Station via South Division Street & Ellicott Loop, Buffalo, and Cleveland Bus Station in around 13h 25m.

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