Port Authority NYNJ operates a train from Times Square to Little Italy every 5 minutes. Tickets cost $3 and the journey takes 4 min. Alternatively, Eastern Shuttle operates a bus from Times Square to Little Italy hourly, and the journey takes 30 min. 3 other operators also service this route.
From 33rd Street train to 9th Street. 4 min $2. From 42 St - Bryant Pk subway to Broadway-Lafayette St. 7 min $2. From Penn bus to New York. 30 min $14. From Times Square taxi to Little Italy. 7 min $22. From Times Square Uber to Little Italy. 7 min $13. From Times Square walk to Little Italy. 54 min. From Broadway & W 41 St Bikeshare to Cleveland Pl & Spring St. 28 min $9.