London Underground (Tube) operates a train from The O2 Arena to Aylesbury every 5 minutes. Tickets cost $4 - $6 and the journey takes 19 min. Chiltern Railways also services this route every 30 minutes.
How to get from The O2 Arena to Aylesbury
From The O2 Arena walk to North Greenwich Underground Station, Tube to London Marylebone, then train to Aylesbury. 1 h 35 min £24. From The O2 Arena walk to North Greenwich Underground Station, Tube to Lisson Grove, Dorset Square Baker Street Station, bus to Hemel Hempstead, Marlowes, then bus to Aylesbury, Bus Station (Aylesbury Bus Station). 2 h 37 min £15. From The O2 Arena drive to Aylesbury. 1 h 12 min £9.