There are 7 ways to get from Tampa to Great Smoky Mountains by plane, car, train or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly from Tampa, drive  •  7 h 13 min

  1. Fly from Tampa (TPA) to Knoxville (TYS) TPA - TYS
  2. Drive from Knoxville to Great Smoky Mountains

$170 - $864

Cheapest option

Bus Greyhound USA, Megabus, drive  •  18 h 26 min

  1. Take the bus from Tampa, Fl to Atlanta, Ga
  2. Take the Megabus from Atlanta GA to Knoxville
  3. Drive from Mountain Grove SB before Majestic Grove to Great Smoky Mountains

$85 - $178

5 alternative options

Fly from St. Petersburg, drive  •  6 h 25 min

  1. Fly from St. Petersburg (PIE) to Knoxville (TYS) PIE - TYS
  2. Drive from Knoxville to Great Smoky Mountains

$104 - $328

Train to Orlando Sanford, fly, drive  •  7 h 33 min

  1. Take the train from Tampa Amtrak to Orlando Amtrak
  2. Fly from Orlando Sanford (SFB) to Knoxville (TYS) SFB - TYS
  3. Drive from Knoxville to Great Smoky Mountains

$130 - $287

Bus La Cubana, Megabus, drive  •  14 h 47 min

  1. Take the bus from Tampa, FL to Atlanta, GA
  2. Take the Megabus from Atlanta GA to Knoxville
  3. Drive from Knoxville to Great Smoky Mountains

$190 - $207

Train, bus, drive  •  24 h 5 min

  1. Take the train from Tampa Amtrak to Cary Amtrak
  2. Take the train from Cary Amtrak to Greensboro Galyon Transportation Center Amtrak
  3. Take the bus from Greensboro, Nc to Winston Salem, Nc
  4. Take the bus from Winston Salem, Nc to Asheville, Nc
  5. Drive from Asheville, Nc to Great Smoky Mountains

$164 - $420

Drive  •  11 h 16 min

  1. Drive from Tampa to Great Smoky Mountains 643.5 miles

$60 - $95

What companies run services between Tampa, FL, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Tampa to Great Smoky Mountains. However, you can take the line 30 bus to Airport Rental Car Facility, take the walk to SkyConnect Rental Car Facility Station, take the bus to SkyConnect Passenger Terminal Station, take the walk to Tampa airport, fly to Knoxville, then take the drive to Great Smoky Mountains. Alternatively, you can take the line 300 bus to Ulmerton Rd + 60Th St N, take the line 59 bus to Psta 34Th St Layby - Platform - D, take the walk to Psta 34Th St Layby - Platform - A, take the line 52 bus to 49Th St N + 14805, take the walk to St. Petersburg airport, fly to Knoxville, then take the drive to Great Smoky Mountains.

Airlines
American Airlines
Website
aa.com
Flights from Tampa to Knoxville via Charlotte
Ave. Duration
4 h 14 min
When
Every day
Estimated price
$190 - $900
Flights from Tampa to Knoxville via Philadelphia
Ave. Duration
5 h 55 min
When
Every day
Estimated price
$250 - $1,100
Flights from Tampa to Knoxville via Reagan Washington
Ave. Duration
6 h 16 min
When
Sunday
Estimated price
$230 - $1,000
Flights from Tampa to Knoxville via Dallas/Ft.Worth
Ave. Duration
6 h 32 min
When
Every day
Estimated price
$270 - $1,100
Delta
Website
delta.com
Flights from Tampa to Knoxville via Atlanta
Ave. Duration
3 h 39 min
When
Every day
Estimated price
$160 - $850
Flights from Tampa to Knoxville via Detroit
Ave. Duration
5 h 25 min
When
Every day
Estimated price
$230 - $1,100
United Airlines
Website
united.com
Flights from Tampa to Knoxville via Washington Dulles
Ave. Duration
5 h 4 min
When
Every day
Estimated price
$240 - $1,100
Flights from Tampa to Knoxville via Chicago O'Hare
Ave. Duration
5 h 38 min
When
Every day
Estimated price
$250 - $1,100
Flights from Tampa to Knoxville via Houston
Ave. Duration
6 h 4 min
When
Monday to Saturday
Estimated price
$260 - $1,100
Allegiant Air
Website
allegiantair.com
Flights from St. Petersburg to Knoxville
Ave. Duration
1 h 38 min
When
Tuesday, Thursday, Saturday and Sunday
Estimated price
$90 - $310
Flights from Orlando Sanford to Knoxville
Ave. Duration
1 h 36 min
When
Every day
Estimated price
$110 - $380
Train operators
Amtrak
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Tampa Amtrak to Orlando Amtrak
Ave. Duration
1 h 49 min
Frequency
Once daily
Estimated price
$29 - $65
Website
amtrak.com
Coach Seat
$29 - $45
Flexi Coach Seat
$50 - $75
Business Coach Seat
$40 - $65
Room
$150 - $220
Train from Tampa Amtrak to Cary Amtrak
Ave. Duration
14 h 41 min
Frequency
Once daily
Estimated price
$100 - $290
Website
amtrak.com
Coach Seat
$100 - $150
Flexi Coach Seat
$180 - $260
Business Coach Seat
$200 - $290
Room
$410 - $600
Train from Cary Amtrak to Greensboro Galyon Transportation Center Amtrak
Ave. Duration
1 h 20 min
Frequency
Every 4 hours
Estimated price
$26 - $55
Website
amtrak.com
Coach Seat
$26 - $40
Flexi Coach Seat
$45 - $70
Business Coach Seat
$35 - $55
Room
$140 - $210
Bus operators
La Cubana
Phone
+1 305-541-1700
Website
lacubanabus.com
Bus from Tampa, FL to Atlanta, GA
Ave. Duration
7 h 15 min
Frequency
3 times a week
Estimated price
$159
Schedules at
lacubanabus.com
Greyhound USA
Phone
+1 214-849-8100
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Tampa, Fl to Atlanta, Ga
Ave. Duration
10 h 50 min
Frequency
Every 3 hours
Estimated price
$50 - $130
Website
greyhound.com
Economy
$50 - $85
Flexible
$100 - $130
Bus from Greensboro, Nc to Winston Salem, Nc
Ave. Duration
45 min
Frequency
Hourly
Estimated price
$9 - $20
Website
greyhound.com
Economy
$9 - $14
Flexible
$16 - $20
Bus from Winston Salem, Nc to Asheville, Nc
Ave. Duration
2 h 55 min
Frequency
Every 2 hours
Estimated price
$20 - $50
Website
greyhound.com
Economy
$20 - $30
Flexible
$35 - $50

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Questions & Answers

How far is it from Tampa to Great Smoky Mountains?

The distance between Tampa and Great Smoky Mountains is 855 km. The road distance is 1030 km.

What is the cheapest way to get from Tampa to Great Smoky Mountains?

The cheapest way to get from Tampa to Great Smoky Mountains is to drive which costs $60 - $95 and takes 11 h 16 min.

What is the fastest way to get from Tampa to Great Smoky Mountains?

The quickest way to get from Tampa to Great Smoky Mountains is to fly and drive which takes 6 h 25 min and costs $100 - $330.

How long does it take to get from Tampa to Great Smoky Mountains?

It takes approximately 7 h 13 min to get from Tampa to Great Smoky Mountains, including transfers.