There are 7 ways to get from Tampa to Great Smoky Mountains by plane, car, train or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Tampa to Knoxville, drive  •  7 h 15 min

  1. Fly from Tampa (TPA) to Knoxville (TYS) TPA - TYS
  2. Drive from Knoxville to Great Smoky Mountains

$168 - $862

Cheapest option

Fly St. Petersburg to Knoxville, drive  •  6 h 32 min

  1. Fly from St. Petersburg (PIE) to Knoxville (TYS) PIE - TYS
  2. Drive from Knoxville to Great Smoky Mountains

$104 - $328

5 alternative options

Fly Tampa to Asheville, drive  •  5 h 43 min

  1. Fly from Tampa (TPA) to Asheville (AVL) TPA - AVL
  2. Drive from Asheville to Great Smoky Mountains

$300 - $864

Fly St. Petersburg to Asheville, drive  •  6 h 34 min

  1. Fly from St. Petersburg (PIE) to Asheville (AVL) PIE - AVL
  2. Drive from Asheville to Great Smoky Mountains

$106 - $330

Train to Orlando Sanford, fly to Knoxville, drive  •  7 h 26 min

  1. Take the train from Tampa Amtrak to Orlando Amtrak
  2. Fly from Orlando Sanford (SFB) to Knoxville (TYS) SFB - TYS
  3. Drive from Knoxville to Great Smoky Mountains

$130 - $287

Bus, drive  •  13 h 46 min

  1. Take the bus from Tampa, FL to Greenville, SC
  2. Drive from Greenville, SC to ART Station
  3. Drive from Pisgah View Rd at Canterbury Apartments to Great Smoky Mountains

$173 - $181

Drive  •  11 h 16 min

  1. Drive from Tampa to Great Smoky Mountains 643.5 miles

$60 - $95

Questions & Answers

The cheapest way to get from Tampa to Great Smoky Mountains is to drive which costs $60 - $95 and takes 11 h 16 min.

More details

The quickest way to get from Tampa to Great Smoky Mountains is to fly and drive which costs $300 - $900 and takes 5 h 43 min.

More details

The distance between Tampa and Great Smoky Mountains is 534 miles. The road distance is 643.5 miles.

Get driving directions

It takes approximately 7 h 15 min to get from Tampa to Great Smoky Mountains, including transfers.

More details

Yes, the driving distance between Tampa to Great Smoky Mountains is 644 miles. It takes approximately 11 h 16 min to drive from Tampa to Great Smoky Mountains.

Get driving directions

Map of how to get from Tampa to Great Smoky Mountains.
Launch map view
  • Distance: 534.3 miles
  • Duration: 7 h 15 min

What companies run services between Tampa, FL, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Tampa to Great Smoky Mountains. However, you can take the bus to Airport Rental Car Facility, take the walk to SkyConnect Rental Car Facility Station, take the bus to SkyConnect Passenger Terminal Station, take the walk to Tampa airport, fly to Knoxville, then take the drive to Great Smoky Mountains. Alternatively, you can take the bus to Airport Rental Car Facility, take the walk to SkyConnect Rental Car Facility Station, take the bus to SkyConnect Passenger Terminal Station, take the walk to Tampa airport, fly to Asheville, then take the drive to Great Smoky Mountains.

Airlines
Delta
Website
delta.com
Flights from Tampa to Knoxville via Atlanta
Ave. Duration
3 h 59 min
When
Every day
Estimated price
$160 - $850
Flights from Tampa to Knoxville via Detroit
Ave. Duration
5 h 35 min
When
Every day
Estimated price
$230 - $1,100
Flights from Tampa to Asheville via Atlanta
Ave. Duration
3 h 47 min
When
Every day
Estimated price
$290 - $1,100
American Airlines
Website
aa.com
Flights from Tampa to Knoxville via Charlotte
Ave. Duration
3 h 48 min
When
Every day
Estimated price
$190 - $900
Flights from Tampa to Knoxville via Reagan Washington
Ave. Duration
4 h 47 min
When
Every day
Estimated price
$230 - $1,000
Flights from Tampa to Knoxville via Philadelphia
Ave. Duration
5 h 45 min
When
Every day
Estimated price
$250 - $1,100
Flights from Tampa to Knoxville via Dallas/Ft.Worth
Ave. Duration
5 h 48 min
When
Every day
Estimated price
$270 - $1,100
Flights from Tampa to Asheville via Charlotte
Ave. Duration
3 h 44 min
When
Every day
Estimated price
$300 - $1,200
United Airlines
Website
united.com
Flights from Tampa to Knoxville via Washington Dulles
Ave. Duration
4 h 59 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$240 - $1,100
Flights from Tampa to Knoxville via Chicago O'Hare
Ave. Duration
5 h 23 min
When
Every day
Estimated price
$250 - $1,100
Flights from Tampa to Knoxville via Houston
Ave. Duration
5 h 40 min
When
Every day
Estimated price
$260 - $1,100
Allegiant Air
Website
allegiantair.com
Flights from St. Petersburg to Knoxville
Ave. Duration
1 h 45 min
When
Tuesday, Thursday, Saturday and Sunday
Estimated price
$90 - $310
Flights from St. Petersburg to Asheville
Ave. Duration
1 h 36 min
When
Every day
Estimated price
$90 - $310
Flights from Orlando Sanford to Knoxville
Ave. Duration
1 h 34 min
When
Monday, Tuesday, Wednesday, Friday and Saturday
Estimated price
$110 - $380
Spirit Airlines
Website
spirit.com
Flights from Tampa to Asheville
Ave. Duration
1 h 42 min
When
Thursday and Sunday
Estimated price
$90 - $420
Train operators
Amtrak
Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Tampa Amtrak to Orlando Amtrak
Ave. Duration
1 h 49 min
Frequency
Once daily
Estimated price
$29 - $65
Website
amtrak.com
Coach Seat
$29 - $45
Flexi Coach Seat
$50 - $75
Business Coach Seat
$40 - $65
Room
$150 - $220
Bus operators
La Cubana
Phone
+1 305-541-1700
Website
lacubanabus.com
Bus from Tampa, FL to Greenville, SC
Ave. Duration
9 h 15 min
Frequency
3 times a week
Estimated price
$159
Schedules at
lacubanabus.com

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