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There is 1 way to get from Tampa to Cayo Santa María by plane or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly, bus  •  10h 37m

  1. Fly from Tampa (TPA) to Santa Clara (SNU) TPA - SNU
  2. Take the bus from Santa Clara to Cayo Santa María

$152 - $785

Questions & Answers

The cheapest way to get from Tampa to Cayo Santa María is to fly and bus which costs $150 - $800 and takes 10h 37m.

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The quickest way to get from Tampa to Cayo Santa María is to fly and bus which costs $150 - $800 and takes 10h 37m.

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The distance between Tampa and Cayo Santa María is 426 miles.

It takes approximately 10h 37m to get from Tampa to Cayo Santa María, including transfers.

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There is no direct flight from Tampa Airport to Santa Clara Airport. The quickest flight takes 4h 14m and has one stopover.

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Southwest Airlines, JetBlue Airways and American Airlines offer flights from Tampa Airport to Santa Clara Airport.

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There are two+ hotels available in Cayo Santa María. Prices start at $100 USD per night.

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Map of how to get from Tampa to Cayo Santa María.
Launch map view
  • Distance: 425.9 miles
  • Duration: 10h 37m

What companies run services between Tampa, FL, USA and Cayo Santa María, Sancti Spíritus, Cuba?

There is no direct connection from Tampa to Cayo Santa María. However, you can take the bus to Airport Rental Car Facility, take the walk to SkyConnect Rental Car Facility Station, take the bus to SkyConnect Passenger Terminal Station, take the walk to Tampa airport, fly to Santa Clara, take the taxi to Santa Clara, then take the bus to Cayo Santa María.

Airlines
American Airlines
Website
aa.com
Flights from Tampa to Santa Clara via Miami
Ave. Duration
4h 14m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$120 - $1,100
Flights from Tampa to Santa Clara via Charlotte, Miami
Ave. Duration
8h 39m
When
Every day
Estimated price
$230 - $1,500
JetBlue Airways
Website
jetblue.com
Flights from Tampa to Santa Clara via Fort Lauderdale
Ave. Duration
4h 50m
When
Monday to Friday
Estimated price
$130 - $750
Bus operators

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