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How to get fromSyracuse, Ny to St. Louisby plane, train (Amtrak), bus (Flixbus, Greyhound), car, bus or train

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There are 8 ways to get from Syracuse, Ny to St. Louis by plane, train (Amtrak), bus (Flixbus, Greyhound), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Syracuse Hancock International Airport to Lambert–St. Louis International Airport

    best
    1. Fly from Syracuse Hancock International Airport (SYR) to Lambert–St. Louis International Airport (STL)planeSYR - STL
    6h 46m
    $204–1,111

  2. Bus

    cheapest
    1. Take the bus from Syracuse Bus Station to Newark Penn StationbusFlixBus N2686 / ...
    2. Take the bus from Newark Penn Station to St Louis Bus StationbusGreyhound US0421
    27h 30m
    $156–444

  3. Train (Amtrak)

    1. Take the train from Syracuse Regional Transportation Center to Chicago Union StationtrainLake Shore Limited
    2. Take the train from Chicago Union Station to St. LouistrainLincoln Service / ...
    18h 53m
    $167–543

  4. Drive 880.2 mi

    1. Drive from Syracuse, Ny to St. Louiscar880.2 mi
    14h 53m
    $161–232

  5. Bus to Greater Binghamton Airport, fly to Lambert–St. Louis International Airport

    1. Take the bus from Syracuse Bus Station to Binghamtonbus
    2. Fly from Greater Binghamton Airport (BGM) to Lambert–St. Louis International Airport (STL)planeBGM - STL
    10h 36m
    $176–737

  6. Bus to Rochester, fly to Lambert–St. Louis International Airport

    1. Take the bus from Syracuse, NY to Rochester, NYbus
    2. Fly from Rochester (ROC) to Lambert–St. Louis International Airport (STL)planeROC - STL
    9h 32m
    $175–879

  7. Fly Syracuse Hancock International Airport to Abraham Lincoln Capital Airport, train

    1. Fly from Syracuse Hancock International Airport (SYR) to Abraham Lincoln Capital Airport (SPI)planeSYR - SPI
    2. Take the train from Springfield to St. Louistrain
    9h 5m
    $192–979

  8. Train, bus

    1. Take the train from Syracuse Regional Transportation Center to Chicago Union StationtrainLake Shore Limited
    2. Take the bus from Chicago Bus Station to St Louis Bus StationbusFlixBus N2521 / ...
    20h 26m
    $167–323

Syracuse, Ny to St. Louis by train (Amtrak)

Calendar14Weekly Trains
Duration18h 53mAverage Duration
Ticket$167Cheapest Price
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Questions & Answers

What companies run services between Syracuse, Ny, NY, USA and St. Louis, MO, USA?

Delta, American Airlines, and United Airlines fly from Syracuse Hancock International Airport (SYR) to Lambert–St. Louis International Airport (STL) every 2 hours. Alternatively, you can take a train from Syracuse Regional Transportation Center to St. Louis via Chicago Union Station in around 18h 53m.

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