There are 9 ways to get from Syracuse to South Carolina by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to Greenville/Spartanburg  •  5h 17m

  1. Fly from Syracuse (SYR) to Greenville/Spartanburg (GSP) SYR - GSP

$148 - $706

Cheapest option

Bus via Washington  •  20h 10m

  1. Take the bus from Syracuse to Binghamton
  2. Take the bus from Binghamton, NY to Washington, DC
  3. Take the bus from Washington to Fayetteville, NC
  4. Take the bus from Fayetteville to Florence

$74 - $133

7 alternative options

Fly to Florence  •  5h 31m

  1. Fly from Syracuse (SYR) to Florence (FLO) SYR - FLO

$196 - $972

Fly to Charleston  •  6h 15m

  1. Fly from Syracuse (SYR) to Charleston (CHS) SYR - CHS

$150 - $764

Fly to Columbia  •  6h 28m

  1. Fly from Syracuse (SYR) to Columbia (CAE) SYR - CAE

$170 - $863

Fly to Charlotte, bus  •  5h 57m

  1. Fly from Syracuse (SYR) to Charlotte (CLT) SYR - CLT
  2. Take the bus from Transit Center- Bay X to White Street Park and Ride

$164 - $819

Train  •  18h 21m

  1. Take the train from Syracuse Regional Transportation Center to New York Penn Station Empire Service / ...
  2. Take the train from New York Penn Station to Florence Amtrak Station Palmetto / ...

$114 - $161

Bus  •  22h 40m

  1. Take the bus from Syracuse, Ny to New York, Ny 207 / ...
  2. Take the bus from New York, Ny to Raleigh, Nc
  3. Take the bus from Raleigh, Nc to Florence, Sc

$103 - $158

Drive  •  13h 12m

  1. Drive from Syracuse to Florence 773.9 miles

$75 - $110

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Questions & Answers

The cheapest way to get from Syracuse to South Carolina is to drive which costs $75 - $110 and takes 13h 12m.

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The quickest way to get from Syracuse to South Carolina is to fly which costs $140 - $750 and takes 5h 17m.

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No, there is no direct bus from Syracuse to South Carolina. However, there are services departing from Syracuse and arriving at Florence via Binghamton, NY, Washington and Fayetteville. The journey, including transfers, takes approximately 20h 10m.

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No, there is no direct train from Syracuse to South Carolina station. However, there are services departing from Syracuse Regional Transportation Center and arriving at Florence Amtrak Station via New York Penn Station. The journey, including transfers, takes approximately 18h 21m.

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The distance between Syracuse and South Carolina is 691 miles. The road distance is 773.9 miles.

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The best way to get from Syracuse to South Carolina without a car is to train which takes 18h 21m and costs $110 - $170.

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It takes approximately 5h 17m to get from Syracuse to South Carolina, including transfers.

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Syracuse to South Carolina bus services, operated by Greyhound USA, depart from Syracuse, Ny station.

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Syracuse to South Carolina train services, operated by Amtrak, depart from Syracuse Regional Transportation Center station.

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The best way to get from Syracuse to South Carolina is to fly which takes 5h 17m and costs $140 - $750. Alternatively, you can train, which costs $110 - $170 and takes 18h 21m, you could also bus via Washington, which costs $70 - $140 and takes 20h 10m.

Mode details

Map of how to get from Syracuse to South Carolina.
Launch map view
  • Distance: 691 miles
  • Duration: 5h 17m

What companies run services between Syracuse, NY, USA and South Carolina, USA?

United Airlines, American Airlines and two other airlines fly from Syracuse to Greenville hourly. Alternatively, you can take a train from Syracuse to Florence via New York Penn Station in around 18h 21m.

Airlines
American Airlines
Website
aa.com
Flights from Syracuse to Greenville/Spartanburg via Charlotte
Ave. Duration
4h
When
Every day
Estimated price
$140 - $750
Flights from Syracuse to Greenville/Spartanburg via Reagan Washington
Ave. Duration
5h 22m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$140 - $750
Flights from Syracuse to Greenville/Spartanburg via Philadelphia
Ave. Duration
5h 13m
When
Every day
Estimated price
$140 - $750
Flights from Syracuse to Greenville/Spartanburg via Chicago O'Hare
Ave. Duration
6h 41m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$160 - $800
Flights from Syracuse to Florence via Charlotte
Ave. Duration
4h 14m
When
Every day
Estimated price
$180 - $950
Flights from Syracuse to Florence via Philadelphia, Charlotte
Ave. Duration
6h 15m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$180 - $950
Flights from Syracuse to Florence via Chicago O'Hare, Charlotte
Ave. Duration
7h 53m
When
Every day
Estimated price
$200 - $950
Flights from Syracuse to Florence via Reagan Washington, Charlotte
Ave. Duration
8h 47m
When
Every day
Estimated price
$180 - $950
Flights from Syracuse to Charleston via Philadelphia
Ave. Duration
3h 58m
When
Every day
Estimated price
$150 - $750
Flights from Syracuse to Charleston via Charlotte
Ave. Duration
4h 28m
When
Every day
Estimated price
$150 - $750
Flights from Syracuse to Charleston via Reagan Washington
Ave. Duration
4h 22m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$140 - $750
Flights from Syracuse to Columbia via Charlotte
Ave. Duration
4h 46m
When
Every day
Estimated price
$160 - $850
Flights from Syracuse to Columbia via Philadelphia
Ave. Duration
5h 3m
When
Every day
Estimated price
$160 - $850
Flights from Syracuse to Columbia via Reagan Washington
Ave. Duration
4h 11m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$160 - $850
Flights from Syracuse to Columbia via Philadelphia, Charlotte
Ave. Duration
5h 46m
When
Every day
Estimated price
$160 - $850
Flights from Syracuse to Charlotte
Ave. Duration
2h 4m
When
Every day
Estimated price
$150 - $800
Flights from Syracuse to Charlotte via Philadelphia
Ave. Duration
4h 11m
When
Every day
Estimated price
$150 - $800
Flights from Syracuse to Charlotte via Reagan Washington
Ave. Duration
4h 15m
When
Every day
Estimated price
$150 - $800
Delta
Website
delta.com
Flights from Syracuse to Greenville/Spartanburg via Atlanta
Ave. Duration
4h 45m
When
Every day
Estimated price
$350 - $1,100
Flights from Syracuse to Greenville/Spartanburg via Detroit
Ave. Duration
4h 46m
When
Every day
Estimated price
$330 - $1,000
Flights from Syracuse to Greenville/Spartanburg via New York La Guardia
Ave. Duration
6h 24m
When
Every day
Estimated price
$320 - $900
Flights from Syracuse to Charleston via Atlanta
Ave. Duration
4h 41m
When
Every day
Estimated price
$380 - $1,200
Flights from Syracuse to Charleston via Detroit
Ave. Duration
4h 54m
When
Every day
Estimated price
$380 - $1,200
Flights from Syracuse to Charleston via New York La Guardia
Ave. Duration
5h 13m
When
Every day
Estimated price
$330 - $950
Flights from Syracuse to Charleston via New York JFK
Ave. Duration
5h 14m
When
Every day
Estimated price
$330 - $950
Flights from Syracuse to Columbia via Atlanta
Ave. Duration
4h 27m
When
Every day
Estimated price
$410 - $1,300
Flights from Syracuse to Columbia via New York La Guardia
Ave. Duration
6h 41m
When
Every day
Estimated price
$360 - $1,100
Flights from Syracuse to Charlotte via Detroit
Ave. Duration
4h 25m
When
Monday to Friday
Estimated price
$360 - $1,100
Flights from Syracuse to Charlotte via Atlanta
Ave. Duration
4h 25m
When
Saturday and Sunday
Estimated price
$400 - $1,300
Flights from Syracuse to Charlotte via New York La Guardia
Ave. Duration
4h 26m
When
Monday to Saturday
Estimated price
$320 - $900
United Airlines
Website
united.com
Flights from Syracuse to Greenville/Spartanburg via Washington Dulles
Ave. Duration
3h 49m
When
Every day
Estimated price
$220 - $950
Flights from Syracuse to Greenville/Spartanburg via Chicago O'Hare
Ave. Duration
5h 39m
When
Every day
Estimated price
$230 - $1,000
Flights from Syracuse to Greenville/Spartanburg via Newark
Ave. Duration
5h 28m
When
Every day
Estimated price
$230 - $950
Flights from Syracuse to Charleston via Washington Dulles
Ave. Duration
4h 6m
When
Every day
Estimated price
$230 - $950
Flights from Syracuse to Charleston via Newark
Ave. Duration
5h 23m
When
Every day
Estimated price
$230 - $950
Flights from Syracuse to Charleston via Chicago O'Hare
Ave. Duration
5h 23m
When
Every day
Estimated price
$230 - $1,100
Flights from Syracuse to Columbia via Washington Dulles
Ave. Duration
3h 58m
When
Every day
Estimated price
$260 - $1,100
Flights from Syracuse to Columbia via Chicago O'Hare
Ave. Duration
6h 54m
When
Every day
Estimated price
$260 - $1,200
Flights from Syracuse to Charlotte via Washington Dulles
Ave. Duration
3h 53m
When
Every day
Estimated price
$240 - $1,000
JetBlue Airways
Website
jetblue.com
Flights from Syracuse to Charleston via Boston
Ave. Duration
4h 50m
When
Every day
Estimated price
$160 - $800
Flights from Syracuse to Charleston via New York JFK
Ave. Duration
5h 37m
When
Every day
Estimated price
$160 - $750
Frontier Airlines
Website
flyfrontier.com
Flights from Syracuse to Greenville/Spartanburg via Orlando
Ave. Duration
5h 51m
When
Tuesday, Thursday and Sunday
Estimated price
$110 - $650
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Syracuse Regional Transportation Center to New York Penn Station
Ave. Duration
5h 44m
Frequency
4 times a day
Estimated price
$40 - $65
Website
amtrak.com
Coach Seat
$40 - $65
Premium
$220 - $300
Flexi Coach Seat
$75 - $120
Business Seat
$75 - $120
Train from New York Penn Station to Florence Amtrak Station
Ave. Duration
11h 37m
Frequency
Twice daily
Estimated price
$70 - $100
Website
amtrak.com
Coach Seat
$70 - $100
Premium
$270 - $380
Flexi Coach Seat
$130 - $210
Business Seat
$140 - $210
Bus operators
Charlotte Area Transit System
Phone
+1 704-336-7433
Email
telltransit@charlottenc.gov
Website
charlottenc.gov
Bus from Transit Center- Bay X to White Street Park and Ride
Ave. Duration
57 min
Frequency
Once daily
Estimated price
$3 - $5
Schedules at
charlottenc.gov
Flixbus USA
Phone
(855) 626-8585
Website
flixbus.com
Bus from Syracuse to Binghamton
Ave. Duration
1h 15m
Frequency
4 times a week
Estimated price
$5 - $8
Schedules at
flixbus.com
OurBus
Phone
+1 844-800-6828
Website
ourbus.com
Bus from Binghamton, NY to Washington, DC
Ave. Duration
6h 30m
Frequency
Once a week
Estimated price
$21 - $45
Book at
ourbus.com
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Washington to Fayetteville, NC
Ave. Duration
7h 55m
Frequency
Twice daily
Estimated price
$27 - $50
Book at
megabus.com
Southeastern Stages
Phone
+1 404-591-2750
Email
info@sestages.com
Website
southeasternstages.com
Bus from Fayetteville to Florence
Ave. Duration
1h 30m
Frequency
3 times a day
Estimated price
$20 - $30
Schedules at
southeasternstages.com
Bus from Raleigh to Florence
Ave. Duration
3h 5m
Frequency
Once daily
Estimated price
$25 - $40
Schedules at
southeasternstages.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Syracuse, Ny to New York, Ny
Ave. Duration
5h 5m
Frequency
Every 4 hours
Estimated price
$30 - $45
Website
greyhound.com
Economy
$30 - $45
Flexible
$55 - $80
Bus from New York, Ny to Raleigh, Nc
Ave. Duration
12h 20m
Frequency
Hourly
Estimated price
$50 - $75
Website
greyhound.com
Economy
$50 - $75
Flexible
$85 - $120
Bus from Raleigh, Nc to Florence, Sc
Ave. Duration
3h 30m
Frequency
5 times a day
Estimated price
$21 - $30
Website
greyhound.com
Economy
$21 - $30
Flexible
$40 - $60

Want to know more about travelling around United States

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More Questions & Answers

There is no direct flight from Syracuse Airport to Greenville/Spartanburg Airport. The quickest flight takes 3h 45m and has one stopover.

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Syracuse to South Carolina bus services, operated by Greyhound USA, arrive at Florence, Sc station.

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Syracuse to South Carolina train services, operated by Amtrak, arrive at Florence Amtrak Station.

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Yes, the driving distance between Syracuse to South Carolina is 774 miles. It takes approximately 13h 12m to drive from Syracuse to South Carolina.

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Frontier Airlines, United Airlines, American Airlines and Delta offer flights from Syracuse Airport to Greenville/Spartanburg Airport.

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Book your Syracuse to South Carolina train tickets online with Omio and Omio.

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Book your Syracuse to South Carolina bus tickets online with Greyhound, Greyhound and Greyhound.

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There are 24+ hotels available in South Carolina. Prices start at $100 USD per night.

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The best way to get from Syracuse to Syracuse Airport is to bus which takes 15 min and costs $8 - $12.

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