There are 12 ways to get from Syracuse to South Carolina by plane, train, night bus, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Syracuse to Charlotte  •  3 h 53 min

  1. Fly from Syracuse (SYR) to Charlotte (CLT) SYR - CLT

$215 - $565

Cheapest option

Bus Greyhound USA  •  20 h 53 min

  1. Take the bus from Syracuse, Ny to New York, Ny 329
  2. Take the bus from New York, Ny to Fayetteville, Nc
  3. Take the bus from Fayetteville, Nc to Florence, Sc

$98 - $244

10 alternative options

Fly Syracuse to Columbia  •  5 h 12 min

  1. Fly from Syracuse (SYR) to Columbia (CAE) SYR - CAE

$254 - $1,145

Fly Syracuse to Greenville/Spartanburg  •  5 h 9 min

  1. Fly from Syracuse (SYR) to Greenville/Spartanburg (GSP) SYR - GSP

$230 - $1,010

Fly Syracuse to Florence  •  5 h 37 min

  1. Fly from Syracuse (SYR) to Florence (FLO) SYR - FLO

$278 - $1,226

Fly Syracuse to Charleston  •  6 h 2 min

  1. Fly from Syracuse (SYR) to Charleston (CHS) SYR - CHS

$232 - $1,118

Train to Rochester, fly to Charlotte  •  5 h 47 min

  1. Take the train from Syracuse Regional Transportation Center Amtrak to Rochester Amtrak
  2. Fly from Rochester (ROC) to Charlotte (CLT) ROC - CLT

$234 - $798

Night bus, train  •  16 h 52 min

  1. Take the night bus from Syracuse, Ny to Newark, Nj 311
  2. Take the train from Newark Penn Station Amtrak to Florence Amtrak Palmetto / ...

$119 - $317

Train  •  18 h 34 min

  1. Take the train from Syracuse Regional Transportation Center Amtrak to New York Penn Station Empire Service / ...
  2. Take the train from New York Penn Station to Florence Amtrak Palmetto / ...

$142 - $391

Train via Albany-Rensselaer Amtrak  •  18 h 59 min

  1. Take the train from Syracuse Regional Transportation Center Amtrak to Albany-Rensselaer Amtrak
  2. Take the train from Albany-Rensselaer Amtrak to New York Penn Station
  3. Take the train from New York Penn Station to Florence Amtrak

$166 - $426

Bus Wanda Coach  •  21 h 31 min

  1. Take the bus from Destiny USA to New York, NY - Port Authority
  2. Take the bus from New York, NY to Florence, SC Nyc / ...

$113 - $152

Drive  •  13 h 12 min

  1. Drive from Syracuse to Florence 775.4 miles

$75 - $110

Questions & Answers

The cheapest way to get from Syracuse to South Carolina is to drive which costs $75 - $110 and takes 13 h 12 min.

More details

The quickest way to get from Syracuse to South Carolina is to fly which costs $210 - $600 and takes 3 h 53 min.

More details

The distance between Syracuse and South Carolina is 691 miles. The road distance is 775.4 miles.

Get driving directions

It takes approximately 3 h 53 min to get from Syracuse to South Carolina, including transfers.

More details

No, there is no direct bus from Syracuse to South Carolina. However, there are services departing from Syracuse, Ny and arriving at Florence, Sc via New York, Ny and Fayetteville, Nc. The journey, including transfers, takes approximately 20 h 53 min.

More details

No, there is no direct train from Syracuse to South Carolina. However, there are services departing from Syracuse Regional Transportation Center Amtrak and arriving at Florence Amtrak via New York Penn Station. The journey, including transfers, takes approximately 18 h 34 min.

More details

United Airlines and American Airlines offer flights from Syracuse Airport to Charlotte Airport.

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Book your Syracuse to South Carolina train tickets online with Rome2rio.

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Map of how to get from Syracuse to South Carolina.
Launch map view
  • Distance: 691 miles
  • Duration: 3 h 53 min

What companies run services between Syracuse, NY, USA and South Carolina, USA?

American Airlines, United Airlines and three other airlines fly from Syracuse to Rock Hill hourly. Alternatively, you can take a train from Syracuse to Florence via New York Penn Station in around 18 h 34 min.

Airlines
American Airlines
Website
aa.com
Flights from Syracuse to Charlotte
Ave. Duration
2 h 9 min
When
Every day
Estimated price
$340 - $850
Flights from Syracuse to Charlotte via Reagan Washington
Ave. Duration
4 h 10 min
When
Every day
Estimated price
$340 - $850
Flights from Syracuse to Charlotte via Philadelphia
Ave. Duration
4 h 40 min
When
Every day
Estimated price
$340 - $850
Flights from Syracuse to Columbia via Reagan Washington
Ave. Duration
4 h 21 min
When
Every day
Estimated price
$230 - $1,100
Flights from Syracuse to Columbia via Charlotte
Ave. Duration
4 h 55 min
When
Every day
Estimated price
$230 - $1,100
Flights from Syracuse to Columbia via Philadelphia
Ave. Duration
5 h 51 min
When
Every day
Estimated price
$240 - $1,100
Flights from Syracuse to Columbia via Reagan Washington, Charlotte
Ave. Duration
5 h 36 min
When
Saturday
Estimated price
$230 - $1,100
Flights from Syracuse to Greenville/Spartanburg via Charlotte
Ave. Duration
4 h 20 min
When
Every day
Estimated price
$190 - $950
Flights from Syracuse to Greenville/Spartanburg via Reagan Washington
Ave. Duration
4 h 21 min
When
Every day
Estimated price
$190 - $950
Flights from Syracuse to Greenville/Spartanburg via Philadelphia
Ave. Duration
4 h 8 min
When
Every day
Estimated price
$200 - $950
Flights from Syracuse to Greenville/Spartanburg via Chicago O'Hare
Ave. Duration
6 h 39 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$230 - $1,000
Flights from Syracuse to Florence via Charlotte
Ave. Duration
4 h 49 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$260 - $1,200
Flights from Syracuse to Florence via Reagan Washington, Charlotte
Ave. Duration
7 h 40 min
When
Every day
Estimated price
$260 - $1,300
Flights from Syracuse to Florence via Chicago O'Hare, Charlotte
Ave. Duration
8 h 6 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$320 - $1,400
Flights from Syracuse to Florence via Philadelphia, Charlotte
Ave. Duration
7 h 56 min
When
Monday to Friday
Estimated price
$260 - $1,300
Flights from Syracuse to Charleston via Philadelphia
Ave. Duration
4 h 33 min
When
Every day
Estimated price
$240 - $1,100
Flights from Syracuse to Charleston via Reagan Washington
Ave. Duration
4 h 22 min
When
Every day
Estimated price
$230 - $1,100
Flights from Syracuse to Charleston via Charlotte
Ave. Duration
4 h 27 min
When
Every day
Estimated price
$230 - $1,100
Flights from Rochester to Charlotte
Ave. Duration
2 h 7 min
When
Every day
Estimated price
$200 - $1,300
Flights from Rochester to Charlotte via Reagan Washington
Ave. Duration
4 h 19 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $1,300
Delta
Website
delta.com
Flights from Syracuse to Columbia via Atlanta
Ave. Duration
4 h 54 min
When
Every day
Estimated price
$240 - $1,200
Flights from Syracuse to Columbia via New York La Guardia
Ave. Duration
6 h 45 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$220 - $1,100
Flights from Syracuse to Greenville/Spartanburg via Detroit
Ave. Duration
5 h 10 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$190 - $950
Flights from Syracuse to Greenville/Spartanburg via New York La Guardia
Ave. Duration
5 h 28 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$190 - $950
Flights from Syracuse to Greenville/Spartanburg via Atlanta
Ave. Duration
5 h 29 min
When
Every day
Estimated price
$200 - $950
Flights from Syracuse to Charleston via Atlanta
Ave. Duration
4 h 57 min
When
Every day
Estimated price
$240 - $1,200
Flights from Syracuse to Charleston via New York La Guardia
Ave. Duration
5 h 9 min
When
Every day
Estimated price
$220 - $1,100
Flights from Syracuse to Charleston via New York JFK
Ave. Duration
4 h 46 min
When
Every day
Estimated price
$220 - $1,100
Flights from Syracuse to Charleston via Detroit
Ave. Duration
5 h 3 min
When
Every day
Estimated price
$240 - $1,200
Flights from Rochester to Charlotte via Detroit
Ave. Duration
4 h 19 min
When
Saturday
Estimated price
$170 - $1,100
United Airlines
Website
united.com
Flights from Syracuse to Charlotte via Washington Dulles
Ave. Duration
4 h 4 min
When
Every day
Estimated price
$270 - $1,100
Flights from Syracuse to Charlotte via Newark
Ave. Duration
4 h 39 min
When
Every day
Estimated price
$270 - $1,100
Flights from Syracuse to Columbia via Washington Dulles
Ave. Duration
5 h 23 min
When
Every day
Estimated price
$240 - $1,200
Flights from Syracuse to Columbia via Chicago O'Hare
Ave. Duration
6 h 17 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$290 - $1,300
Flights from Syracuse to Greenville/Spartanburg via Washington Dulles
Ave. Duration
4 h 1 min
When
Every day
Estimated price
$200 - $1,000
Flights from Syracuse to Greenville/Spartanburg via Newark
Ave. Duration
5 h 13 min
When
Every day
Estimated price
$210 - $1,000
Flights from Syracuse to Greenville/Spartanburg via Chicago O'Hare
Ave. Duration
5 h 8 min
When
Saturday
Estimated price
$240 - $1,100
Flights from Syracuse to Charleston via Washington Dulles
Ave. Duration
4 h 5 min
When
Every day
Estimated price
$250 - $1,200
Flights from Syracuse to Charleston via Newark
Ave. Duration
5 h 7 min
When
Saturday
Estimated price
$250 - $1,200
Flights from Syracuse to Charleston via Chicago O'Hare
Ave. Duration
5 h 36 min
When
Every day
Estimated price
$300 - $1,300
Flights from Rochester to Charlotte via Washington Dulles
Ave. Duration
4 h 9 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$220 - $1,100
Southwest Airlines
Website
southwest.com
Flights from Rochester to Charlotte via Baltimore
Ave. Duration
3 h 43 min
When
Every day
Estimated price
$210 - $1,300
Train operators
Amtrak
Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Syracuse Regional Transportation Center Amtrak to Rochester Amtrak
Ave. Duration
1 h 10 min
Frequency
Every 4 hours
Estimated price
$27 - $60
Website
amtrak.com
Coach Seat
$27 - $40
Flexi Coach Seat
$45 - $70
Business Coach Seat
$40 - $60
Room
$150 - $210
Train from Newark Penn Station Amtrak to Florence Amtrak
Ave. Duration
11 h 27 min
Frequency
Twice daily
Estimated price
$90 - $250
Website
amtrak.com
Coach Seat
$90 - $140
Flexi Coach Seat
$160 - $230
Business Coach Seat
$180 - $250
Room
$370 - $550
Train from Syracuse Regional Transportation Center Amtrak to New York Penn Station
Ave. Duration
5 h 44 min
Frequency
4 times a day
Estimated price
$50 - $140
Website
amtrak.com
Coach Seat
$50 - $80
Flexi Coach Seat
$90 - $130
Business Coach Seat
$95 - $140
Room
$230 - $330
Train from New York Penn Station to Florence Amtrak
Ave. Duration
11 h 50 min
Frequency
Twice daily
Estimated price
$90 - $260
Website
amtrak.com
Coach Seat
$90 - $140
Flexi Coach Seat
$160 - $230
Business Coach Seat
$180 - $260
Room
$370 - $550
Train from Syracuse Regional Transportation Center Amtrak to Albany-Rensselaer Amtrak
Ave. Duration
2 h 39 min
Frequency
Every 4 hours
Estimated price
$35 - $85
Website
amtrak.com
Coach Seat
$35 - $55
Flexi Coach Seat
$60 - $90
Business Coach Seat
$55 - $85
Room
$180 - $250
Train from Albany-Rensselaer Amtrak to New York Penn Station
Ave. Duration
2 h 33 min
Frequency
Hourly
Estimated price
$40 - $85
Website
amtrak.com
Coach Seat
$40 - $85
Business Seat
$65 - $110
Bedroom
$270 - $330
VIA Rail
Phone
+1 1 888 842-7245
Website
viarail.ca
Train from Syracuse to Rochester
Ave. Duration
1 h 14 min
Frequency
Every 3 hours
Estimated price
$26 - $75
Website
viarail.ca
Escape
$26 - $40
Economy
$30 - $50
Economy Plus
$50 - $75
Business
$45 - $70
Business Plus/Sleeper
$85 - $130
Train from Syracuse to Albany
Ave. Duration
3 h 21 min
Frequency
Every 3 hours
Estimated price
$30 - $100
Website
viarail.ca
Escape
$30 - $45
Economy
$45 - $65
Economy Plus
$70 - $100
Business
$65 - $95
Business Plus/Sleeper
$120 - $170
Bus operators
Greyhound USA
Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Night bus from Syracuse, Ny to Newark, Nj
Ave. Duration
4 h 25 min
Frequency
Hourly
Estimated price
$28 - $70
Website
greyhound.com
Economy
$28 - $45
Flexible
$50 - $70
Bus from Syracuse, Ny to New York, Ny
Ave. Duration
4 h 55 min
Frequency
Hourly
Estimated price
$29 - $70
Website
greyhound.com
Economy
$29 - $45
Flexible
$50 - $70
Bus from New York, Ny to Fayetteville, Nc
Ave. Duration
13 h 45 min
Frequency
Hourly
Estimated price
$55 - $140
Website
greyhound.com
Economy
$55 - $90
Flexible
$100 - $140
Bus from Fayetteville, Nc to Florence, Sc
Ave. Duration
1 h 35 min
Frequency
Every 30 minutes
Estimated price
$14 - $35
Website
greyhound.com
Economy
$14 - $22
Flexible
$26 - $35
Trailways New York
Website
trailwaysny.com
Bus from Destiny USA to New York, NY - Port Authority
Ave. Duration
7 h 5 min
Frequency
Once daily
Estimated price
$40 - $75
Schedules at
trailwaysny.com
Book at
trailwaysny.com
Wanda Coach
Phone
6466307186
Email
help@wandacoach.com
Website
wandacoach.com
Bus from New York, NY to Florence, SC
Ave. Duration
11 h 45 min
Frequency
5 times a day
Estimated price
$55
Schedules at
wandacoach.com
Starline Bus
Website
starlinebus.com
Bus from New York, NY to Florence, SC
Ave. Duration
11 h 15 min
Frequency
Twice daily
Estimated price
$55
Schedules at
starlinebus.com
Book at
gotobus.com

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