There are 11 ways to get from Syracuse to South Carolina by plane, train, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Syracuse to Charlotte  •  3 h 56 min

  1. Fly from Syracuse (SYR) to Charlotte (CLT) SYR - CLT

$215 - $565

Cheapest option

Bus Megabus  •  24 h 41 min

  1. Take the bus from Syracuse, NY to New York, NY
  2. Take the bus from New York to Fayetteville
  3. Take the bus from Fayetteville, Nc to Florence, Sc

$91 - $147

9 alternative options

Fly Syracuse to Columbia  •  5 h 16 min

  1. Fly from Syracuse (SYR) to Columbia (CAE) SYR - CAE

$254 - $1,145

Fly Syracuse to Florence  •  5 h 21 min

  1. Fly from Syracuse (SYR) to Florence (FLO) SYR - FLO

$278 - $1,226

Fly Syracuse to Greenville/Spartanburg  •  5 h 12 min

  1. Fly from Syracuse (SYR) to Greenville/Spartanburg (GSP) SYR - GSP

$230 - $1,010

Fly Syracuse to Charleston  •  6 h 13 min

  1. Fly from Syracuse (SYR) to Charleston (CHS) SYR - CHS

$232 - $1,118

Train to Rochester, fly to Charlotte  •  5 h 58 min

  1. Take the train from Syracuse to Rochester
  2. Fly from Rochester (ROC) to Charlotte (CLT) ROC - CLT

$233 - $817

Bus to Buffalo, fly to Charlotte  •  6 h 23 min

  1. Take the bus from Syracuse, Ny to Buffalo, Ny
  2. Fly from Buffalo (BUF) to Charlotte (CLT) BUF - CLT

$233 - $754

Train  •  18 h 24 min

  1. Take the train from Syracuse to New York VIA Rail
  2. Take the train from New York Penn Station to Florence Amtrak Palmetto / ...

$138 - $413

Bus  •  20 h 55 min

  1. Take the bus from Syracuse, Ny to New York, Ny 329
  2. Take the bus from New York, Ny to Fayetteville, Nc
  3. Take the bus from Fayetteville, Nc to Florence, Sc

$98 - $244

Drive  •  13 h 12 min

  1. Drive from Syracuse to Florence 775.4 miles

$75 - $110

What companies run services between Syracuse, NY, USA and South Carolina, USA?

American Airlines, United Airlines and three other airlines fly from Syracuse to Rock Hill hourly. Alternatively, you can take a train from Syracuse to Florence via New York and New York Penn Station in around 18 h 24 min.

Airlines
American Airlines
Website
aa.com
Flights from Syracuse to Charlotte
Ave. Duration
2 h 9 min
When
Every day
Estimated price
$340 - $850
Flights from Syracuse to Charlotte via Philadelphia
Ave. Duration
4 h 21 min
When
Every day
Estimated price
$340 - $850
Flights from Syracuse to Charlotte via Reagan Washington
Ave. Duration
4 h 16 min
When
Every day
Estimated price
$340 - $850
Flights from Syracuse to Columbia via Charlotte
Ave. Duration
4 h 12 min
When
Every day
Estimated price
$230 - $1,100
Flights from Syracuse to Columbia via Philadelphia
Ave. Duration
4 h 30 min
When
Every day
Estimated price
$240 - $1,100
Flights from Syracuse to Columbia via Reagan Washington
Ave. Duration
4 h 25 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$230 - $1,100
Flights from Syracuse to Columbia via Philadelphia, Charlotte
Ave. Duration
5 h 48 min
When
Every day
Estimated price
$240 - $1,100
Flights from Syracuse to Florence via Charlotte
Ave. Duration
5 h 5 min
When
Every day
Estimated price
$260 - $1,200
Flights from Syracuse to Florence via Reagan Washington, Charlotte
Ave. Duration
6 h 22 min
When
Saturday
Estimated price
$260 - $1,300
Flights from Syracuse to Florence via Philadelphia, Charlotte
Ave. Duration
7 h 6 min
When
Every day
Estimated price
$260 - $1,300
Flights from Syracuse to Florence via Chicago O'Hare, Charlotte
Ave. Duration
8 h 3 min
When
Every day
Estimated price
$320 - $1,400
Flights from Syracuse to Greenville/Spartanburg via Charlotte
Ave. Duration
4 h 2 min
When
Every day
Estimated price
$190 - $950
Flights from Syracuse to Greenville/Spartanburg via Reagan Washington
Ave. Duration
4 h 5 min
When
Monday to Friday
Estimated price
$190 - $950
Flights from Syracuse to Greenville/Spartanburg via Philadelphia
Ave. Duration
4 h 9 min
When
Every day
Estimated price
$200 - $950
Flights from Syracuse to Greenville/Spartanburg via Chicago O'Hare
Ave. Duration
6 h 21 min
When
Every day
Estimated price
$230 - $1,000
Flights from Syracuse to Charleston via Charlotte
Ave. Duration
4 h 40 min
When
Every day
Estimated price
$230 - $1,100
Flights from Syracuse to Charleston via Philadelphia
Ave. Duration
5 h 36 min
When
Every day
Estimated price
$240 - $1,100
Flights from Syracuse to Charleston via Reagan Washington
Ave. Duration
4 h 28 min
When
Every day
Estimated price
$230 - $1,100
Flights from Rochester to Charlotte
Ave. Duration
2 h 11 min
When
Every day
Estimated price
$200 - $1,300
Flights from Rochester to Charlotte via Philadelphia
Ave. Duration
4 h 18 min
When
Every day
Estimated price
$200 - $1,300
Flights from Rochester to Charlotte via Reagan Washington
Ave. Duration
4 h 26 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $1,300
Flights from Buffalo to Charlotte
Ave. Duration
1 h 54 min
When
Every day
Estimated price
$270 - $1,200
Flights from Buffalo to Charlotte via Reagan Washington
Ave. Duration
4 h
When
Monday to Saturday
Estimated price
$270 - $1,200
Flights from Buffalo to Charlotte via Philadelphia
Ave. Duration
4 h 14 min
When
Every day
Estimated price
$270 - $1,200
United Airlines
Website
united.com
Flights from Syracuse to Charlotte via Washington Dulles
Ave. Duration
3 h 58 min
When
Every day
Estimated price
$270 - $1,100
Flights from Syracuse to Columbia via Washington Dulles
Ave. Duration
5 h 23 min
When
Every day
Estimated price
$240 - $1,200
Flights from Syracuse to Columbia via Chicago O'Hare
Ave. Duration
7 h 18 min
When
Every day
Estimated price
$290 - $1,300
Flights from Syracuse to Greenville/Spartanburg via Washington Dulles
Ave. Duration
3 h 53 min
When
Every day
Estimated price
$200 - $1,000
Flights from Syracuse to Greenville/Spartanburg via Chicago O'Hare
Ave. Duration
5 h 46 min
When
Every day
Estimated price
$240 - $1,100
Flights from Syracuse to Greenville/Spartanburg via Newark
Ave. Duration
5 h 50 min
When
Every day
Estimated price
$210 - $1,000
Flights from Syracuse to Charleston via Washington Dulles
Ave. Duration
4 h 25 min
When
Every day
Estimated price
$250 - $1,200
Flights from Syracuse to Charleston via Chicago O'Hare
Ave. Duration
5 h 17 min
When
Every day
Estimated price
$300 - $1,300
Flights from Syracuse to Charleston via Newark
Ave. Duration
6 h 24 min
When
Every day
Estimated price
$250 - $1,200
Flights from Rochester to Charlotte via Washington Dulles
Ave. Duration
4 h 5 min
When
Every day
Estimated price
$220 - $1,100
Flights from Buffalo to Charlotte via Washington Dulles
Ave. Duration
3 h 54 min
When
Every day
Estimated price
$260 - $1,400
Delta
Website
delta.com
Flights from Syracuse to Charlotte via New York La Guardia
Ave. Duration
4 h 20 min
When
Saturday
Estimated price
$280 - $950
Flights from Syracuse to Charlotte via Detroit
Ave. Duration
4 h 28 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$280 - $950
Flights from Syracuse to Columbia via Atlanta
Ave. Duration
5 h 21 min
When
Every day
Estimated price
$240 - $1,200
Flights from Syracuse to Columbia via New York La Guardia
Ave. Duration
5 h 45 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$220 - $1,100
Flights from Syracuse to Greenville/Spartanburg via Atlanta
Ave. Duration
4 h 41 min
When
Every day
Estimated price
$200 - $950
Flights from Syracuse to Greenville/Spartanburg via Detroit
Ave. Duration
5 h 6 min
When
Every day
Estimated price
$190 - $950
Flights from Syracuse to Greenville/Spartanburg via New York La Guardia
Ave. Duration
5 h 56 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$190 - $950
Flights from Syracuse to Charleston via New York La Guardia
Ave. Duration
5 h 50 min
When
Every day
Estimated price
$220 - $1,100
Flights from Syracuse to Charleston via New York JFK
Ave. Duration
4 h 29 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$220 - $1,100
Flights from Syracuse to Charleston via Detroit
Ave. Duration
5 h 17 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$240 - $1,200
Flights from Syracuse to Charleston via Atlanta
Ave. Duration
5 h 41 min
When
Every day
Estimated price
$240 - $1,200
Flights from Buffalo to Charlotte via Detroit
Ave. Duration
3 h 49 min
When
Saturday
Estimated price
$260 - $1,000
Southwest Airlines
Website
southwest.com
Flights from Rochester to Charlotte via Baltimore
Ave. Duration
3 h 57 min
When
Every day
Estimated price
$210 - $1,300
Flights from Buffalo to Charlotte via Baltimore
Ave. Duration
3 h 52 min
When
Every day
Estimated price
$310 - $1,200
Air Canada
Website
aircanada.com
Flights from Syracuse to Charlotte via Toronto
Ave. Duration
4 h 19 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $800
Flights from Syracuse to Charleston via Chicago O'Hare
Ave. Duration
5 h 17 min
When
Every day
Estimated price
$300 - $1,300
Flights from Rochester to Charlotte via Toronto
Ave. Duration
4 h 19 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$180 - $750
JetBlue Airways
Website
jetblue.com
Flights from Syracuse to Charleston via Boston
Ave. Duration
4 h 41 min
When
Every day
Estimated price
$250 - $1,100
Train operators
VIA Rail
Phone
+1 1 888 842-7245
Website
viarail.ca
Train from Syracuse to Rochester
Ave. Duration
1 h 16 min
Frequency
Every 3 hours
Estimated price
$26 - $80
Website
viarail.ca
Escape
$26 - $40
Economy
$35 - $50
Economy Plus
$55 - $80
Business
$45 - $70
Business Plus/Sleeper
$90 - $130
Train from Syracuse to New York
Ave. Duration
5 h 34 min
Frequency
Every 3 hours
Estimated price
$45 - $160
Website
viarail.ca
Escape
$45 - $70
Economy
$75 - $110
Economy Plus
$110 - $160
Business
$110 - $160
Business Plus/Sleeper
$200 - $280
Amtrak
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Syracuse Regional Transportation Center Amtrak to Rochester Amtrak
Ave. Duration
1 h 14 min
Frequency
5 times a day
Estimated price
$27 - $60
Website
amtrak.com
Coach Seat
$27 - $40
Flexi Coach Seat
$45 - $70
Business Coach Seat
$40 - $60
Room
$150 - $210
Train from New York Penn Station to Florence Amtrak
Ave. Duration
11 h 50 min
Frequency
4 times a day
Estimated price
$90 - $260
Website
amtrak.com
Coach Seat
$90 - $140
Flexi Coach Seat
$160 - $230
Business Coach Seat
$180 - $260
Room
$370 - $550
Bus operators
Greyhound USA
Phone
+1 214-849-8100
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Syracuse, Ny to Buffalo, Ny
Ave. Duration
2 h 30 min
Frequency
Hourly
Estimated price
$20 - $50
Website
greyhound.com
Economy
$20 - $35
Flexible
$35 - $50
Bus from Syracuse, Ny to New York, Ny
Ave. Duration
4 h 55 min
Frequency
Hourly
Estimated price
$29 - $70
Website
greyhound.com
Economy
$29 - $45
Flexible
$50 - $70
Bus from New York, Ny to Fayetteville, Nc
Ave. Duration
13 h 45 min
Frequency
Hourly
Estimated price
$55 - $140
Website
greyhound.com
Economy
$55 - $90
Flexible
$100 - $140
Bus from Fayetteville, Nc to Florence, Sc
Ave. Duration
1 h 35 min
Frequency
Every 30 minutes
Estimated price
$14 - $35
Website
greyhound.com
Economy
$14 - $22
Flexible
$26 - $35
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Syracuse, NY to New York, NY
Ave. Duration
5 h 30 min
Frequency
5 times a day
Estimated price
$25 - $40
Schedules at
us.megabus.com
Bus from New York to Fayetteville
Ave. Duration
15 h
Frequency
Once daily
Estimated price
$50 - $70
Schedules at
us.megabus.com

Want to know more about travelling around United States

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Questions & Answers

How far is it from Syracuse to South Carolina?

The distance between Syracuse and South Carolina is 1106 km. The road distance is 1241 km.

What is the cheapest way to get from Syracuse to South Carolina?

The cheapest way to get from Syracuse to South Carolina is to drive which costs $75 - $110 and takes 13 h 12 min.

What is the fastest way to get from Syracuse to South Carolina?

The quickest way to get from Syracuse to South Carolina is to fly which takes 3 h 56 min and costs $210 - $600.

Is there a direct train between Syracuse and South Carolina?

No, there is no direct train from Syracuse to South Carolina. However, there are services departing from Syracuse and arriving at Florence Amtrak via New York Penn Station. The journey, including transfers, takes approximately 18 h 24 min.

Is there a direct bus between Syracuse and South Carolina?

No, there is no direct bus from Syracuse to South Carolina. However, there are services departing from Syracuse, Ny and arriving at Florence, Sc via New York, Ny and Fayetteville, Nc. The journey, including transfers, takes approximately 20 h 55 min.

How long does it take to get from Syracuse to South Carolina?

It takes approximately 3 h 56 min to get from Syracuse to South Carolina, including transfers.