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  • Greyhound USA
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  • Amtrak
  • Acela Express
  • Megabus
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There are 8 ways to get from Syracuse to Louisville by plane, bus, train, night bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Syracuse to Louisville  •  6h 42m

  1. Fly from Syracuse (SYR) to Louisville (SDF) SYR - SDF

$179 - $914

Cheapest option

Bus Barons Bus  •  17h 20m

  1. Take the bus from Syracuse, Ny to Buffalo, Ny 248 / ...
  2. Take the bus from Buffalo, NY to Cincinnati, OH
  3. Take the bus from Cincinnati, Oh to Lexington, Ky
  4. Take the bus from Lexington, KY to Louisville, KY

$90 - $277

6 alternative options

Fly Syracuse to Lexington, bus  •  8h 9m

  1. Fly from Syracuse (SYR) to Lexington (LEX) SYR - LEX
  2. Take the bus from Lexington, KY to Louisville, KY

$236 - $1,096

Train to Rochester, fly to Louisville  •  8h 17m

  1. Take the train from Syracuse Regional Transportation Center to Rochester Amtrak Station
  2. Fly from Rochester (ROC) to Louisville (SDF) ROC - SDF

$180 - $861

Train, night bus, bus  •  16h 30m

  1. Take the train from Syracuse Regional Transportation Center to Cleveland Amtrak Station
  2. Take the night bus from Cleveland, Oh to Cincinnati, Oh
  3. Take the bus from Cincinnati, Oh to Lexington, Ky
  4. Take the bus from Lexington, KY to Louisville, KY

$123 - $352

Bus SkyHorse / Jaguar  •  20h 39m

  1. Take the bus from Syracuse, NY to New York, NY New York-Syracuse Route
  2. Take the bus from New York, NY to Louisville, KY

$91 - $109

Train, bus  •  22h 51m

  1. Take the train from Syracuse Regional Transportation Center to Chicago Union Station
  2. Take the train from Chicago Union Station to Indianapolis Amtrak Station
  3. Take the bus from Delaware St & Market St Indianapolis to Louisville, KY

$148 - $388

Drive  •  11h 28m

  1. Drive from Syracuse to Louisville 680 miles

$65 - $100

Questions & Answers

The cheapest way to get from Syracuse to Louisville is to drive which costs $65 - $100 and takes 11h 28m.

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The quickest way to get from Syracuse to Louisville is to fly which costs $170 - $950 and takes 6h 42m.

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No, there is no direct bus from Syracuse to Louisville. However, there are services departing from Syracuse, Ny and arriving at Louisville, KY via Buffalo, NY, Cincinnati, Oh and Lexington, KY. The journey, including transfers, takes approximately 17h 20m.

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The distance between Syracuse and Louisville is 606 miles. The road distance is 680 miles.

Get driving directions

The best way to get from Syracuse to Louisville without a car is to train and night bus and bus which takes 16h 30m and costs $120 - $360.

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It takes approximately 6h 42m to get from Syracuse to Louisville, including transfers.

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Syracuse to Louisville bus services, operated by Greyhound USA, depart from Syracuse, Ny station.

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The best way to get from Syracuse to Louisville is to fly which takes 6h 42m and costs $170 - $950. Alternatively, you can bus, which costs $90 - $280 and takes 17h 20m.

Mode details

There is no direct flight from Syracuse Airport to Louisville Airport. The quickest flight takes 4h 22m and has one stopover.

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Syracuse to Louisville bus services, operated by Hoosier Ride, arrive at Louisville, KY station.

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Map of how to get from Syracuse to Louisville.
Launch map view
  • Distance: 605.9 miles
  • Duration: 6h 42m

What companies run services between Syracuse, NY, USA and Louisville, KY, USA?

United Airlines, American Airlines and Delta fly from Syracuse to Louisville hourly. Alternatively, you can take a bus from Syracuse to Louisville via Buffalo, Ny, Buffalo, NY, Cincinnati, OH, Cincinnati, Oh, Lexington, Ky, and Lexington, KY in around 17h 20m.

Airlines
American Airlines
Website
aa.com
Flights from Syracuse to Louisville via Reagan Washington
Ave. Duration
5h 4m
When
Every day
Estimated price
$190 - $900
Flights from Syracuse to Louisville via Charlotte
Ave. Duration
5h 34m
When
Every day
Estimated price
$210 - $950
Flights from Syracuse to Louisville via Chicago O'Hare
Ave. Duration
6h 33m
When
Every day
Estimated price
$200 - $950
Flights from Syracuse to Louisville via Philadelphia
Ave. Duration
6h 53m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $950
Flights from Syracuse to Lexington via Charlotte
Ave. Duration
5h 42m
When
Every day
Estimated price
$210 - $1,000
Flights from Syracuse to Lexington via Philadelphia
Ave. Duration
6h 33m
When
Every day
Estimated price
$200 - $950
Flights from Syracuse to Lexington via Chicago O'Hare
Ave. Duration
7h 31m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$220 - $1,000
Flights from Rochester to Louisville via Reagan Washington
Ave. Duration
5h 14m
When
Every day
Estimated price
$180 - $850
Flights from Rochester to Louisville via Chicago O'Hare
Ave. Duration
5h 13m
When
Every day
Estimated price
$180 - $850
Flights from Rochester to Louisville via Charlotte
Ave. Duration
5h 34m
When
Every day
Estimated price
$190 - $850
Flights from Rochester to Louisville via Philadelphia
Ave. Duration
5h 44m
When
Every day
Estimated price
$180 - $850
Delta
Website
delta.com
Flights from Syracuse to Louisville via Detroit
Ave. Duration
4h 48m
When
Every day
Estimated price
$170 - $900
Flights from Syracuse to Louisville via Atlanta
Ave. Duration
5h 52m
When
Every day
Estimated price
$210 - $1,000
Flights from Syracuse to Louisville via New York La Guardia
Ave. Duration
5h 43m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$190 - $950
Flights from Syracuse to Lexington via Detroit
Ave. Duration
5h 44m
When
Monday to Saturday
Estimated price
$180 - $950
Flights from Syracuse to Lexington via Atlanta
Ave. Duration
5h 13m
When
Every day
Estimated price
$210 - $1,000
Flights from Rochester to Louisville via Detroit
Ave. Duration
4h 48m
When
Every day
Estimated price
$150 - $800
Flights from Rochester to Louisville via New York La Guardia
Ave. Duration
5h 43m
When
Every day
Estimated price
$180 - $850
Flights from Rochester to Louisville via Atlanta
Ave. Duration
5h 56m
When
Every day
Estimated price
$190 - $900
United Airlines
Website
united.com
Flights from Syracuse to Louisville via Washington Dulles
Ave. Duration
4h 30m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $950
Flights from Syracuse to Louisville via Newark
Ave. Duration
5h 58m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$210 - $1,000
Flights from Syracuse to Louisville via Chicago O'Hare
Ave. Duration
6h 3m
When
Every day
Estimated price
$210 - $1,000
Flights from Syracuse to Lexington via Washington Dulles
Ave. Duration
4h 23m
When
Sunday
Estimated price
$210 - $1,000
Flights from Syracuse to Lexington via Chicago O'Hare
Ave. Duration
6h 23m
When
Every day
Estimated price
$230 - $1,100
Flights from Rochester to Louisville via Washington Dulles
Ave. Duration
4h 7m
When
Every day
Estimated price
$190 - $900
Flights from Rochester to Louisville via Chicago O'Hare
Ave. Duration
5h 21m
When
Every day
Estimated price
$190 - $900
Flights from Rochester to Louisville via Newark
Ave. Duration
5h 39m
When
Sunday
Estimated price
$200 - $900
Southwest Airlines
Website
southwest.com
Flights from Rochester to Louisville via Baltimore
Ave. Duration
4h 55m
When
Monday to Saturday
Estimated price
$190 - $800
Flights from Rochester to Louisville via Tampa
Ave. Duration
5h 55m
When
Sunday
Estimated price
$290 - $1,100
Allegiant Air
Website
allegiantair.com
Flights from Syracuse to Lexington via Fort Lauderdale
Ave. Duration
6h 46m
When
Thursday and Sunday
Estimated price
$250 - $1,300
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Syracuse Regional Transportation Center to Rochester Amtrak Station
Ave. Duration
1h 14m
Frequency
5 times a day
Estimated price
$27 - $60
Website
amtrak.com
Coach Seat
$27 - $40
Flexi Coach Seat
$45 - $70
Business Coach Seat
$40 - $60
Room
$150 - $210
Train from Syracuse Regional Transportation Center to Cleveland Amtrak Station
Ave. Duration
5h 41m
Frequency
Twice daily
Estimated price
$55 - $150
Website
amtrak.com
Coach Seat
$55 - $85
Flexi Coach Seat
$95 - $150
Business Coach Seat
$100 - $150
Room
$250 - $350
Train from Syracuse Regional Transportation Center to Chicago Union Station
Ave. Duration
12h 58m
Frequency
Twice daily
Estimated price
$95 - $270
Website
amtrak.com
Coach Seat
$95 - $140
Flexi Coach Seat
$160 - $240
Business Coach Seat
$190 - $270
Room
$390 - $550
Train from Chicago Union Station to Indianapolis Amtrak Station
Ave. Duration
4h 54m
Frequency
Once daily
Estimated price
$40 - $100
Website
amtrak.com
Coach Seat
$40 - $60
Flexi Coach Seat
$70 - $110
Business Coach Seat
$70 - $100
Room
$200 - $280
VIA Rail
Phone
+1 1 888 842-7245
Website
viarail.ca
Train from Syracuse to Rochester
Ave. Duration
1h 19m
Frequency
Once daily
Estimated price
$40 - $85
Website
viarail.ca
Escape
$20 - $45
Economy
$40 - $60
EconomyPlus
$60 - $85
Business
$55 - $85
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Night bus from Cleveland, Oh to Cincinnati, Oh
Ave. Duration
4h 35m
Frequency
Once daily
Estimated price
$29 - $70
Website
greyhound.com
Economy
$29 - $45
Flexible
$50 - $70
Bus from Cincinnati, Oh to Lexington, Ky
Ave. Duration
1h 25m
Frequency
4 times a day
Estimated price
$14 - $35
Website
greyhound.com
Economy
$14 - $21
Flexible
$25 - $35
Bus from Syracuse, Ny to Buffalo, Ny
Ave. Duration
2h 30m
Frequency
Every 4 hours
Estimated price
$20 - $50
Website
greyhound.com
Economy
$20 - $35
Flexible
$35 - $50
OurBus
Phone
+1 844-800-6828
Website
ourbus.com
Bus from Syracuse, NY to New York, NY
Ave. Duration
4h 40m
Frequency
5 times a week
Estimated price
$16 - $35
Book at
ourbus.com
SkyHorse / Jaguar
Phone
+1 917.288.6888
Email
vaseagull@gotobus.com
Website
skyhorsebus.com
Bus from New York, NY to Louisville, KY
Ave. Duration
13h 45m
Frequency
Once daily
Estimated price
$70
Schedules at
gotobus.com
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Delaware St & Market St Indianapolis to Louisville, KY
Ave. Duration
2h 45m
Frequency
Twice daily
Estimated price
$12 - $23
Book at
megabus.com

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

Yes, the driving distance between Syracuse to Louisville is 680 miles. It takes approximately 11h 28m to drive from Syracuse to Louisville.

Get driving directions

United Airlines, Delta and American Airlines offer flights from Syracuse Airport to Louisville Airport.

Search flights

There are 190+ hotels available in Louisville. Prices start at $64 USD per night.

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The best way to get from Syracuse to Syracuse Airport is to bus which takes 15m and costs $8 - $12.

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