Select from 4 ways to get there

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly from Syracuse  •  6 h 30 min

  1. Fly from Syracuse (SYR) to Louisville (SDF) SYR - SDF

$181 - $918

Cheapest option

Bus  •  17 h 37 min

  1. Take the bus from Syracuse, Ny to Buffalo, Ny
  2. Take the bus from Buffalo, NY to Cincinnati, OH
  3. Take the bus from Cincinnati, Oh to Lexington, Ky
  4. Take the bus from Lexington, KY to Louisville, KY

$95 - $205

5 alternative options

Train to Rochester, fly  •  7 h 54 min

  1. Take the train from Syracuse Regional Transportation Center Amtrak to Rochester Amtrak
  2. Fly from Rochester (ROC) to Louisville (SDF) ROC - SDF

$180 - $861

Train, bus via Cleveland Amtrak  •  15 h 45 min

  1. Take the train from Syracuse Regional Transportation Center Amtrak to Cleveland Amtrak
  2. Take the bus from Cleveland, Oh to Columbus, Oh
  3. Take the bus from Columbus, Oh to Cincinnati, Oh
  4. Take the bus from Cincinnati, Oh to Lexington, Ky
  5. Take the bus from Lexington, KY to Louisville, KY

$129 - $300

Train, bus Spring Tour Bus  •  21 h 16 min

  1. Take the train from Syracuse to New York VIA Rail
  2. Take the bus from New York City, NY to Louisville, KY

$131 - $248

Train, bus  •  22 h 28 min

  1. Take the train from Syracuse Regional Transportation Center Amtrak to Chicago Union Station Amtrak
  2. Take the train from Chicago Union Station Amtrak to Indianapolis Amtrak
  3. Take the bus from Indianapolis, IN to Louisville, KY

$148 - $388

Drive  •  11 h 28 min

  1. Drive from Syracuse to Louisville 680 miles

$65 - $100

What companies run services between Syracuse, NY, USA and Louisville, KY, USA?

Delta, American Airlines and United Airlines fly from Syracuse to Louisville hourly. Alternatively, you can take a bus from Syracuse to Louisville via Buffalo, Ny, Buffalo, NY, Cincinnati, OH, Cincinnati, Oh, Lexington, Ky, and Lexington, KY in around 17 h 37 min.

Airlines
American Airlines
Website
aa.com
Flights from Syracuse to Louisville via Reagan Washington
Ave. Duration
4 h 59 min
When
Monday to Saturday
Estimated price
$190 - $900
Flights from Syracuse to Louisville via Charlotte
Ave. Duration
5 h 18 min
When
Every day
Estimated price
$210 - $950
Flights from Syracuse to Louisville via Philadelphia
Ave. Duration
5 h 3 min
When
Every day
Estimated price
$200 - $950
Flights from Syracuse to Louisville via Chicago O'Hare
Ave. Duration
6 h 33 min
When
Every day
Estimated price
$200 - $950
Flights from Rochester to Louisville via Charlotte
Ave. Duration
5 h 9 min
When
Every day
Estimated price
$190 - $850
Flights from Rochester to Louisville via Philadelphia
Ave. Duration
4 h 52 min
When
Every day
Estimated price
$180 - $850
Flights from Rochester to Louisville via Reagan Washington
Ave. Duration
4 h 54 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$180 - $850
Flights from Rochester to Louisville via Chicago O'Hare
Ave. Duration
5 h 52 min
When
Every day
Estimated price
$180 - $850
Delta
Website
delta.com
Flights from Syracuse to Louisville via Detroit
Ave. Duration
4 h 23 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$170 - $900
Flights from Syracuse to Louisville via Atlanta
Ave. Duration
5 h 15 min
When
Every day
Estimated price
$210 - $1,000
Flights from Syracuse to Louisville via New York La Guardia
Ave. Duration
5 h 40 min
When
Every day
Estimated price
$190 - $950
Flights from Rochester to Louisville via Detroit
Ave. Duration
3 h 37 min
When
Saturday and Sunday
Estimated price
$150 - $800
Flights from Rochester to Louisville via Atlanta
Ave. Duration
5 h 20 min
When
Every day
Estimated price
$190 - $900
Flights from Rochester to Louisville via New York La Guardia
Ave. Duration
5 h 42 min
When
Every day
Estimated price
$180 - $850
Flights from Rochester to Louisville via Minneapolis
Ave. Duration
6 h 23 min
When
Monday to Friday
Estimated price
$210 - $950
United Airlines
Website
united.com
Flights from Syracuse to Louisville via Washington Dulles
Ave. Duration
4 h 43 min
When
Every day
Estimated price
$200 - $950
Flights from Syracuse to Louisville via Chicago O'Hare
Ave. Duration
5 h 47 min
When
Every day
Estimated price
$210 - $1,000
Flights from Syracuse to Louisville via Newark
Ave. Duration
5 h 12 min
When
Every day
Estimated price
$210 - $1,000
Flights from Rochester to Louisville via Chicago O'Hare
Ave. Duration
5 h 12 min
When
Every day
Estimated price
$190 - $900
Flights from Rochester to Louisville via Washington Dulles
Ave. Duration
4 h 35 min
When
Every day
Estimated price
$190 - $900
Flights from Rochester to Louisville via Newark
Ave. Duration
5 h 3 min
When
Every day
Estimated price
$200 - $900
Southwest Airlines
Website
southwest.com
Flights from Rochester to Louisville via Baltimore
Ave. Duration
4 h 17 min
When
Monday to Saturday
Estimated price
$190 - $800
Train operators
Amtrak
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Syracuse Regional Transportation Center Amtrak to Rochester Amtrak
Ave. Duration
1 h 10 min
Frequency
Every 4 hours
Estimated price
$27 - $60
Website
amtrak.com
Coach Seat
$27 - $40
Flexi Coach Seat
$45 - $70
Business Coach Seat
$40 - $60
Room
$150 - $210
Train from Syracuse Regional Transportation Center Amtrak to Cleveland Amtrak
Ave. Duration
5 h 38 min
Frequency
Twice daily
Estimated price
$55 - $150
Website
amtrak.com
Coach Seat
$55 - $85
Flexi Coach Seat
$95 - $150
Business Coach Seat
$100 - $150
Room
$250 - $350
Train from Syracuse Regional Transportation Center Amtrak to Chicago Union Station Amtrak
Ave. Duration
12 h 56 min
Frequency
Twice daily
Estimated price
$95 - $270
Website
amtrak.com
Coach Seat
$95 - $140
Flexi Coach Seat
$160 - $240
Business Coach Seat
$190 - $270
Room
$390 - $550
Train from Chicago Union Station Amtrak to Indianapolis Amtrak
Ave. Duration
4 h 54 min
Frequency
Twice daily
Estimated price
$40 - $100
Website
amtrak.com
Coach Seat
$40 - $60
Flexi Coach Seat
$70 - $110
Business Coach Seat
$70 - $100
Room
$200 - $280
VIA Rail
Phone
+1 1 888 842-7245
Website
viarail.ca
Train from Syracuse to Rochester
Ave. Duration
1 h 16 min
Frequency
Every 3 hours
Estimated price
$26 - $80
Website
viarail.ca
Escape
$26 - $40
Economy
$35 - $50
Economy Plus
$55 - $80
Business
$45 - $70
Business Plus/Sleeper
$90 - $130
Train from Syracuse to New York
Ave. Duration
5 h 34 min
Frequency
Every 3 hours
Estimated price
$45 - $160
Website
viarail.ca
Escape
$45 - $70
Economy
$75 - $110
Economy Plus
$110 - $160
Business
$110 - $160
Business Plus/Sleeper
$200 - $280
Bus operators
Greyhound USA
Phone
+1 214-849-8100
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Cleveland, Oh to Columbus, Oh
Ave. Duration
2 h 25 min
Frequency
Hourly
Estimated price
$19 - $50
Website
greyhound.com
Economy
$19 - $30
Flexible
$35 - $50
Bus from Columbus, Oh to Cincinnati, Oh
Ave. Duration
1 h 55 min
Frequency
Hourly
Estimated price
$16 - $40
Website
greyhound.com
Economy
$16 - $25
Flexible
$29 - $40
Bus from Cincinnati, Oh to Lexington, Ky
Ave. Duration
1 h 25 min
Frequency
Every 30 minutes
Estimated price
$14 - $35
Website
greyhound.com
Economy
$14 - $21
Flexible
$25 - $35
Bus from Syracuse, Ny to Buffalo, Ny
Ave. Duration
2 h 30 min
Frequency
Hourly
Estimated price
$20 - $50
Website
greyhound.com
Economy
$20 - $35
Flexible
$35 - $50
Spring Tour Bus
Phone
+1 917-288-6888 / (513) 658-8886
Email
cs@springtourbus.com
Website
springtourbus.com
Bus from New York City, NY to Louisville, KY
Ave. Duration
12 h 7 min
Frequency
Twice daily
Estimated price
$80
Schedules at
springtourbus.com
Book at
springtourbus.com

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Questions & Answers

The distance between Syracuse and Louisville is 969 km. The road distance is 1088 km.

The cheapest way to get from Syracuse to Louisville is to drive which costs $65 - $100 and takes 11 h 28 min.

The quickest way to get from Syracuse to Louisville is to fly which takes 6 h 30 min and costs $180 - $950.

No, there is no direct bus from Syracuse to Louisville. However, there are services departing from Syracuse, Ny and arriving at Louisville, KY via Buffalo, NY, Cincinnati, Oh and Lexington, KY. The journey, including transfers, takes approximately 17 h 37 min.

It takes approximately 6 h 30 min to get from Syracuse to Louisville, including transfers.