There are 8 ways to get from Syracuse to Louisville by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Syracuse to Louisville  •  6 h 9 min

  1. Fly from Syracuse (SYR) to Louisville (SDF) SYR - SDF

$181 - $918

Cheapest option

Bus Barons Bus  •  16 h 37 min

  1. Take the bus from Syracuse, Ny to Buffalo, Ny
  2. Take the bus from Buffalo, NY to Cincinnati, OH
  3. Take the bus from Cincinnati, Oh to Lexington, Ky
  4. Take the bus from Lexington, KY to Louisville, KY

$90 - $277

6 alternative options

Fly Syracuse to Lexington, bus  •  7 h 28 min

  1. Fly from Syracuse (SYR) to Lexington (LEX) SYR - LEX
  2. Take the bus from Lexington, KY to Louisville, KY

$238 - $1,028

Train to Rochester, fly to Louisville  •  8 h

  1. Take the train from Syracuse to Rochester
  2. Fly from Rochester (ROC) to Louisville (SDF) ROC - SDF

$178 - $879

Train, bus via Superior Av & E 26Th St  •  15 h 24 min

  1. Take the train from Syracuse Regional Transportation Center to Cleveland Amtrak
  2. Take the bus from Cleveland, Oh to Columbus, Oh
  3. Take the bus from Columbus, Oh to Cincinnati, Oh
  4. Take the bus from Cincinnati, Oh to Lexington, Ky
  5. Take the bus from Lexington, KY to Louisville, KY

$129 - $300

Train, bus  •  22 h 49 min

  1. Take the train from Syracuse Regional Transportation Center to Chicago Union Station
  2. Take the train from Chicago Union Station to Indianapolis Amtrak
  3. Take the bus from Delaware St & Market St Indianapolis to Louisville, KY

$148 - $388

Bus Spring Tour Bus  •  22 h 54 min

  1. Take the bus from Destiny USA to New York, NY - Port Authority
  2. Take the bus from New York City, NY to Louisville, KY

$125 - $163

Drive  •  11 h 28 min

  1. Drive from Syracuse to Louisville 680 miles

$65 - $100

Questions & Answers

The cheapest way to get from Syracuse to Louisville is to drive which costs $65 - $100 and takes 11 h 28 min.

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The quickest way to get from Syracuse to Louisville is to fly which costs $180 - $950 and takes 6 h 9 min.

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No, there is no direct bus from Syracuse to Louisville. However, there are services departing from Syracuse, Ny and arriving at Louisville, KY via Buffalo, NY, Cincinnati, Oh and Lexington, KY. The journey, including transfers, takes approximately 16 h 37 min.

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The distance between Syracuse and Louisville is 606 miles. The road distance is 680 miles.

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The best way to get from Syracuse to Louisville without a car is to train and bus which takes 15 h 24 min and costs $120 - $300.

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It takes approximately 6 h 9 min to get from Syracuse to Louisville, including transfers.

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Syracuse to Louisville bus services, operated by Greyhound USA, depart from Syracuse, Ny station.

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The best way to get from Syracuse to Louisville is to fly which takes 6 h 9 min and costs $180 - $950. Alternatively, you can bus, which costs $90 - $280 and takes 16 h 37 min.

Mode details

There is no direct flight from Syracuse Airport to Louisville Airport. The quickest flight takes 3 h 49 min and has one stopover.

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Syracuse to Louisville bus services, operated by Hoosier Ride, arrive at Louisville, KY station.

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Map of how to get from Syracuse to Louisville.
Launch map view
  • Distance: 605.9 miles
  • Duration: 6 h 9 min

What companies run services between Syracuse, NY, USA and Louisville, KY, USA?

Delta, American Airlines and United Airlines fly from Syracuse to Louisville hourly. Alternatively, you can take a bus from Syracuse to Louisville via Buffalo, Ny, Buffalo, NY, Cincinnati, OH, Cincinnati, Oh, Lexington, Ky, and Lexington, KY in around 16 h 37 min.

Airlines
Delta
Website
delta.com
Flights from Syracuse to Louisville via Detroit
Ave. Duration
4 h 13 min
When
Monday to Saturday
Estimated price
$170 - $900
Flights from Syracuse to Louisville via Atlanta
Ave. Duration
5 h 39 min
When
Every day
Estimated price
$210 - $1,000
Flights from Syracuse to Louisville via New York La Guardia
Ave. Duration
5 h 39 min
When
Every day
Estimated price
$190 - $950
Flights from Syracuse to Louisville via Minneapolis
Ave. Duration
6 h 24 min
When
Monday to Friday
Estimated price
$230 - $1,100
Flights from Syracuse to Lexington via Detroit
Ave. Duration
4 h 51 min
When
Monday to Saturday
Estimated price
$180 - $950
Flights from Syracuse to Lexington via New York La Guardia
Ave. Duration
5 h 4 min
When
Monday to Saturday
Estimated price
$190 - $950
Flights from Syracuse to Lexington via Atlanta
Ave. Duration
5 h 1 min
When
Every day
Estimated price
$210 - $1,000
Flights from Rochester to Louisville via Detroit
Ave. Duration
4 h 7 min
When
Monday, Wednesday, Friday and Saturday
Estimated price
$150 - $800
Flights from Rochester to Louisville via Atlanta
Ave. Duration
4 h 29 min
When
Every day
Estimated price
$190 - $900
Flights from Rochester to Louisville via New York La Guardia
Ave. Duration
5 h 24 min
When
Every day
Estimated price
$180 - $850
American Airlines
Website
aa.com
Flights from Syracuse to Louisville via Reagan Washington
Ave. Duration
4 h 41 min
When
Every day
Estimated price
$190 - $900
Flights from Syracuse to Louisville via Philadelphia
Ave. Duration
5 h 37 min
When
Every day
Estimated price
$200 - $950
Flights from Syracuse to Louisville via Charlotte
Ave. Duration
5 h 17 min
When
Every day
Estimated price
$210 - $950
Flights from Syracuse to Louisville via Chicago O'Hare
Ave. Duration
5 h 49 min
When
Every day
Estimated price
$200 - $950
Flights from Syracuse to Lexington via Charlotte
Ave. Duration
5 h 41 min
When
Every day
Estimated price
$210 - $1,000
Flights from Syracuse to Lexington via Chicago O'Hare
Ave. Duration
6 h 17 min
When
Every day
Estimated price
$220 - $1,000
Flights from Syracuse to Lexington via Philadelphia
Ave. Duration
6 h 44 min
When
Every day
Estimated price
$200 - $950
Flights from Rochester to Louisville via Reagan Washington
Ave. Duration
4 h
When
Monday to Friday
Estimated price
$180 - $850
Flights from Rochester to Louisville via Philadelphia
Ave. Duration
5 h 21 min
When
Every day
Estimated price
$180 - $850
Flights from Rochester to Louisville via Charlotte
Ave. Duration
5 h 20 min
When
Every day
Estimated price
$190 - $850
Flights from Rochester to Louisville via Chicago O'Hare
Ave. Duration
5 h 42 min
When
Every day
Estimated price
$180 - $850
United Airlines
Website
united.com
Flights from Syracuse to Louisville via Washington Dulles
Ave. Duration
4 h 25 min
When
Every day
Estimated price
$200 - $950
Flights from Syracuse to Louisville via Chicago O'Hare
Ave. Duration
5 h 12 min
When
Every day
Estimated price
$210 - $1,000
Flights from Syracuse to Louisville via Newark
Ave. Duration
4 h 43 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$210 - $1,000
Flights from Syracuse to Lexington via Chicago O'Hare
Ave. Duration
6 h 50 min
When
Every day
Estimated price
$230 - $1,100
Flights from Syracuse to Lexington via Newark
Ave. Duration
7 h 13 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$220 - $1,000
Flights from Rochester to Louisville via Washington Dulles
Ave. Duration
4 h 20 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$190 - $900
Flights from Rochester to Louisville via Newark
Ave. Duration
5 h 19 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $900
Flights from Rochester to Louisville via Chicago O'Hare
Ave. Duration
5 h 37 min
When
Every day
Estimated price
$190 - $900
Southwest Airlines
Website
southwest.com
Flights from Rochester to Louisville via Baltimore
Ave. Duration
3 h 57 min
When
Monday to Saturday
Estimated price
$190 - $800
Train operators
VIA Rail
Phone
+1 1 888 842-7245
Website
viarail.ca
Train from Syracuse to Rochester
Ave. Duration
1 h 19 min
Frequency
Every 3 hours
Estimated price
$26 - $75
Website
viarail.ca
Escape
$26 - $40
Economy
$30 - $50
Economy Plus
$55 - $75
Business
$45 - $70
Business Plus/Sleeper
$85 - $130
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Syracuse Regional Transportation Center to Rochester Amtrak
Ave. Duration
1 h 14 min
Frequency
5 times a day
Estimated price
$27 - $60
Website
amtrak.com
Coach Seat
$27 - $40
Flexi Coach Seat
$45 - $70
Business Coach Seat
$40 - $60
Room
$150 - $210
Train from Syracuse Regional Transportation Center to Cleveland Amtrak
Ave. Duration
5 h 38 min
Frequency
Twice daily
Estimated price
$55 - $150
Website
amtrak.com
Coach Seat
$55 - $85
Flexi Coach Seat
$95 - $150
Business Coach Seat
$100 - $150
Room
$250 - $350
Train from Syracuse Regional Transportation Center to Chicago Union Station
Ave. Duration
12 h 56 min
Frequency
Twice daily
Estimated price
$95 - $270
Website
amtrak.com
Coach Seat
$95 - $140
Flexi Coach Seat
$160 - $240
Business Coach Seat
$190 - $270
Room
$390 - $550
Train from Chicago Union Station to Indianapolis Amtrak
Ave. Duration
4 h 54 min
Frequency
Once daily
Estimated price
$40 - $100
Website
amtrak.com
Coach Seat
$40 - $60
Flexi Coach Seat
$70 - $110
Business Coach Seat
$70 - $100
Room
$200 - $280
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Cleveland, Oh to Columbus, Oh
Ave. Duration
2 h 25 min
Frequency
Hourly
Estimated price
$19 - $50
Website
greyhound.com
Economy
$19 - $30
Flexible
$35 - $50
Bus from Columbus, Oh to Cincinnati, Oh
Ave. Duration
1 h 55 min
Frequency
Hourly
Estimated price
$16 - $40
Website
greyhound.com
Economy
$16 - $25
Flexible
$29 - $40
Bus from Cincinnati, Oh to Lexington, Ky
Ave. Duration
1 h 25 min
Frequency
Every 30 minutes
Estimated price
$14 - $35
Website
greyhound.com
Economy
$14 - $21
Flexible
$25 - $35
Bus from Syracuse, Ny to Buffalo, Ny
Ave. Duration
2 h 30 min
Frequency
Hourly
Estimated price
$20 - $50
Website
greyhound.com
Economy
$20 - $35
Flexible
$35 - $50
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Delaware St & Market St Indianapolis to Louisville, KY
Ave. Duration
2 h 45 min
Frequency
Twice daily
Estimated price
$12 - $23
Book at
megabus.com
Trailways New York
Phone
(800) 858-8555
Website
trailwaysny.com
Bus from Destiny USA to New York, NY - Port Authority
Ave. Duration
7 h 5 min
Frequency
Once daily
Estimated price
$40 - $75
Book at
trailwaysny.com
Spring Tour Bus
Phone
+1 917-288-6888 / (513) 658-8886
Email
cs@springtourbus.com
Website
springtourbus.com
Bus from New York City, NY to Louisville, KY
Ave. Duration
12 h 7 min
Frequency
Twice daily
Estimated price
$80
Schedules at
springtourbus.com
Book at
springtourbus.com

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More Questions & Answers

Yes, the driving distance between Syracuse to Louisville is 680 miles. It takes approximately 11 h 28 min to drive from Syracuse to Louisville.

Get driving directions

United Airlines, Delta and American Airlines offer flights from Syracuse Airport to Louisville Airport.

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There are 191+ hotels available in Louisville. Prices start at $66 USD per night.

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The best way to get from Syracuse to Syracuse Airport is to bus which takes 15 min and costs $10 - $15.

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