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How to get fromSt. Thomas to St. Louisby plane, train (Amtrak), bus (Flixbus, Greyhound), car, shuttle, bus or train

Find Transport to St. Louis

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There are 6 ways to get from St. Thomas to St. Louis by plane, train (Amtrak), bus (Flixbus, Greyhound), car, shuttle, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from London International Airport

    best
    1. Fly from London International Airport (YXU) to Lambert–St. Louis International Airport (STL)plane plane YXU - STL
    7h 54m
    $320–1,471

  2. Bus

    cheapest
    1. Take the bus from St Thomas to Woodstockbus bus
    2. Take the bus from Woodstock to Detroit Bus Stationbus bus
    3. Take the bus from Detroit, MI to Indianapolis, INbus bus
    4. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus
    18h 30m
    $85–311

  3. Train

    1. Take the train from London to Sarniatrain train
    2. Take the train from Port Huron Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    15h 3m
    $128–458

  4. Drive 632.8 mi

    1. Drive from St. Thomas to St. Louiscar car 632.8 mi
    11h 2m
    $145–210

  5. Shuttle to Detroit, fly

    1. Take a shuttle bus from Days Inn by Wyndham London to Detroit Airportshuttle bus
    2. Fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL)plane plane DTW - STL
    7h 8m
    $284–580

  6. Bus, train

    1. Take the bus from St Thomas to Woodstockbus bus
    2. Take the bus from Woodstock to Detroit Bus Stationbus bus
    3. Take the train from Detroit to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to St. Louistrain train
    19h 57m
    $108–496

St. Thomas to St. Louis by bus

Calendar2Weekly Buses
Duration18h 30mAverage Duration
Ticket$85Cheapest Price
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Questions & Answers

What companies run services between St. Thomas, ON, Canada and St. Louis, MO, USA?

Air Canada, WestJet, and Delta fly from London International Airport (YXU) to Lambert–St. Louis International Airport (STL) twice daily. Alternatively, you can take a vehicle from St. Thomas to St. Louis via London, Sarnia, Port Huron Station, and Chicago Union Station in around 15h 3m.

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