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How to get fromSt. Thomas to Chicagoby train (Amtrak), bus (Flixbus, Greyhound), car, shuttle, plane, bus or train

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There are 9 ways to get from St. Thomas to Chicago by train (Amtrak), bus (Flixbus, Greyhound), car, shuttle, plane, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from London to Sarniatrain train VIA Rail
    2. Take the train from Port Huron Station to Chicago Union Stationtrain train Blue Water
    10h 33m
    $52–273

  2. Bus

    1. Take the bus from London to Detroit Bus Stationbus bus FlixBus 2701 / ...
    2. Take the bus from Detroit Bus Station to Chicago Bus Stationbus bus Greyhound US0160
    12h 40m
    $54–210

  3. Drive 396.4 mi

    1. Drive from St. Thomas to Chicagocar car 396.4 mi
    6h 52m
    $91–131

  4. Shuttle to Detroit, fly to Chicago Midway International Airport

    1. Take a shuttle bus from London, ON - 105, Wharncliffe Road South, Manor Park to Detroit Airportshuttle bus
    2. Fly from Detroit (DTW) to Chicago Midway International Airport (MDW)plane plane DTW - MDW
    8h 14m
    $97–503

  5. Bus, train

    1. Take the bus from London to Detroit Bus Stationbus bus FlixBus 2701 / ...
    2. Take the train from Detroit to Chicago Union Stationtrain train Wolverine
    12h 31m
    $64–240

  6. Shuttle to Detroit, fly to Chicago O'Hare International Airport

    1. Take a shuttle bus from London, ON - 105, Wharncliffe Road South, Manor Park to Detroit Airportshuttle bus
    2. Fly from Detroit (DTW) to Chicago O'Hare International Airport (ORD)plane plane DTW - ORD
    8h 37m
    $162–523

  7. Drive to Erie International Airport, fly to Chicago O'Hare International Airport

    1. Drive from St. Thomas to Erie-Airport-ERIcar car
    2. Fly from Erie International Airport (ERI) to Chicago O'Hare International Airport (ORD)plane plane ERI - ORD
    7h 29m
    $94–340

  8. Bus to Toronto Pearson International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from London, ON to Pearson International Airport Terminal 1bus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Chicago O'Hare International Airport (ORD)plane plane YYZ - ORD
    8h 32m
    $207–595

  9. Shuttle to Detroit, fly to South Bend, train

    1. Take a shuttle bus from London, ON - 105, Wharncliffe Road South, Manor Park to Detroit Airportshuttle bus
    2. Fly from Detroit (DTW) to South Bend (SBN)plane plane DTW - SBN
    3. Take the train from South Bend Airport to Van Buren St.train train
    10h 31m
    $113–563

St. Thomas to Chicago by bus, foot, train, and car

Calendar2Weekly Services
Duration10h 33mAverage Duration
Ticket$52Cheapest Price
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Questions & Answers

What companies run services between St. Thomas, ON, Canada and Chicago, IL, USA?

You can take a bus from St Thomas to Chicago Union Station via London, London, Sarnia, and Port Huron Station in around 10h 33m. Alternatively, you can take a bus from St Thomas to Chicago Bus Station via London and Detroit Bus Station in around 12h 40m.

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