Rome2Rio

How to get fromSt. Louis to San Diegoby plane, bus (Greyhound, Amtrak), train (Amtrak), car, train or bus

Find Transport to San Diego

See all options

There are 5 ways to get from St. Louis to San Diego by plane, bus (Greyhound, Amtrak), train (Amtrak), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to San Diego International Airport (SAN)planeSTL - SAN
    5h 52m
    $364–488

  2. Train, bus

    cheapest
    1. Take the train from St. Louis to Yuma Amtraktrain
    2. Take the bus from 3rd Street @ Gila Street to William Brook Ave @ B Streetbus95
    3. Take the bus from San Luis Río Colorado to Mexicalibus
    4. Take the bus from Mexicali to Tijuanabus
    2d 14h
    $206–707

  3. Bus

    1. Take the bus from St Louis Bus Station to Los Angeles Union StationbusGreyhound US1210
    2. Take the bus from Los Angeles to San DiegobusAmtrak Thruway Connecting Service
    43h 45m

  4. Train (Amtrak)

    1. Take the train from St. Louis to Kansas Citytrain
    2. Take the train from Kansas City to Fullerton Amtrak Stationtrain
    3. Take the train from Fullerton Amtrak Station to San Diegotrain
    44h 55m
    $218–729

  5. Drive 1,797.8 mi

    1. Drive from St. Louis to San Diegocar1,797.8 mi
    29h 2m
    $329–474

Lambert–St. Louis International Airport (STL) to San Diego International Airport (SAN) flights

Calendar54Weekly Planes
Duration5h 17mAverage Duration
Ticket$203Cheapest Price
See schedules

Questions & Answers

What companies run services between St. Louis, MO, USA and San Diego, CA, USA?

Southwest Airlines and United Airlines fly from Lambert–St. Louis International Airport (STL) to San Diego International Airport (SAN) every 4 hours. Alternatively, you can take a bus from St Louis Bus Station to San Diego via Los Angeles Union Station and Los Angeles in around 43h 45m.

Transport is disrupted due to the Russia-Ukraine war. Read more

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers

Where to next?

Trips from St. Louis

Trips to San Diego

Popular routes