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How to get fromSt. Louis to Ohioby plane, bus (Greyhound), or car

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There are 7 ways to get from St. Louis to Ohio by plane, bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Cleveland-Hopkins International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Cleveland-Hopkins International Airport (CLE)plane plane STL - CLE
    3h 38m
    $496–906

  2. Bus

    cheapest
    1. Take the bus from St Louis Bus Station to Columbusbus bus Greyhound US0421
    9h 40m
    $65–130

  3. Bus via Indianapolis

    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    2. Take the bus from Indianapolis to Columbusbus bus FlixBus N2640 / ...
    9h 4m

  4. Drive 416.2 mi

    1. Drive from St. Louis to Columbuscar car 416.2 mi
    7h
    $76–110

  5. Fly to John Glenn Columbus International Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to John Glenn Columbus International Airport (CMH)plane plane STL - CMH
    3h 56m
    $804–906

  6. Fly to Covington

    1. Fly from Lambert–St. Louis International Airport (STL) to Covington (CVG)plane plane STL - CVG
    6h 13m
    $126–708

  7. Fly to Dayton

    1. Fly from Lambert–St. Louis International Airport (STL) to Dayton (DAY)plane plane STL - DAY
    7h 7m
    $214–1,204

Lambert–St. Louis International Airport (STL) to Cleveland-Hopkins International Airport (CLE) flights

Calendar38Weekly Planes
Duration2h 38mAverage Duration
Ticket$112Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Ohio.ExpandLaunch map view
  • Distance: 512.3 mi
  • Duration: 3h 38m

What companies run services between St. Louis, MO, USA and Ohio, USA?

Southwest Airlines and Delta fly from Lambert–St. Louis International Airport (STL) to Cleveland-Hopkins International Airport (CLE) 5 times a day. Alternatively, you can take a bus from St Louis Bus Station to Columbus via Indianapolis, Illinois St (Greyhound Bus Station) and Indianapolis in around 9h 4m.

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