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How to get fromSt. Louis to Muscatineby train, bus, car, plane, or taxi

Find Transport to Muscatine

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There are 6 ways to get from St. Louis to Muscatine by train, bus, car, plane, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus, drive (Amtrak)

    best
    1. Take the train from St. Louis to Springfieldtrain train
    2. Take the bus from Springfield to Galesburg Amtrak Stationbus bus
    3. Drive from Galesburg Amtrak Station to Muscatinecar car
    6h 37m
    $84–139

  2. Drive 233.6 mi

    cheapest
    1. Drive from St. Louis to Muscatinecar car 233.6 mi
    5h 33m
    $43–62

  3. Fly to Quad City International Airport, taxi

    1. Fly from Lambert–St. Louis International Airport (STL) to Quad City International Airport (MLI)plane plane STL - MLI
    2. Take the taxi from Moline-Airport-MLI to Muscatinetaxi taxi
    5h 53m
    $172–562

  4. Train, bus, drive via Bloomington

    1. Take the train from St. Louis to Bloomington-Normaltrain train
    2. Take the bus from Bloomington-Normal to Galesburgbus bus
    3. Drive from Galesburg to Muscatinecar car
    6h 51m
    $76–142

  5. Bus, drive

    1. Take the bus from St Louis Bus Station to Springfield SMTD Transfer Centerbus bus
    2. Take the bus from Springfield to Galesburg Amtrak Stationbus bus
    3. Drive from Galesburg Amtrak Station to Muscatinecar car
    7h 25m
    $68–103

  6. Fly to The Eastern Iowa Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to The Eastern Iowa Airport (CID)plane plane STL - CID
    2. Drive from Cedar-Rapids-Airport-CID to Muscatinecar car
    6h 27m
    $88–478

Lambert–St. Louis International Airport (STL) to Quad City International Airport (MLI) flights

Calendar96Weekly Planes
Duration5h 2mAverage Duration
Ticket$72Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Muscatine.ExpandLaunch map view
  • Distance: 281.3 mi
  • Duration: 6h 37m

What companies run services between St. Louis, MO, USA and Muscatine, IA, USA?

There is no direct connection from St. Louis to Muscatine. However, you can take the train to Springfield, walk to Springfield, take the bus to Galesburg Amtrak Station, then drive to Muscatine. Alternatively, you can drive from St. Louis to Muscatine in around 5h 33m.

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